Search Results - "Hu, Hanbo"

A causal role for uric acid in fructose-induced metabolic syndrome by Nakagawa, Takahiko, Hu, Hanbo, Zharikov, Sergey, Tuttle, Katherine R, Short, Robert A, Glushakova, Olena, Ouyang, Xiaosen, Feig, Daniel I, Block, Edward R, Herrera-Acosta, Jaime, Patel, Jawaharlal M, Johnson, Richard J

“…The worldwide epidemic of metabolic syndrome correlates with an elevation in serum uric acid as well as a marked increase in total fructose intake (in the form…”
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Hypoxia-induced endothelial CX3CL1 triggers lung smooth muscle cell phenotypic switching and proliferative expansion by Zhang, Jianliang, Hu, Hanbo, Palma, Nadia L, Harrison, Jeffrey K, Mubarak, Kamal K, Carrie, Robin D, Alnuaimat, Hassan, Shen, Xiaoqiang, Luo, Defang, Patel, Jawaharlal M

“…Distal arterioles with limited smooth muscles help maintain the high blood flow and low pressure in the lung circulation. Chronic hypoxia induces lung distal…”
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Alpha-1 Antitrypsin Attenuates Acute Lung Allograft Injury in a Rat Lung Transplant Model by Emtiazjoo, Amir M., Hu, Hanbo, Lu, Li, Brantly, Mark L.

“…Ischemia-reperfusion injury (IRI) after lung transplantation triggers a cascade of inflammatory changes that can contribute to acute allograft injury. This…”
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Cell Penetrating Peptide-Mediated Caveolae-Dependent Activation of Lung Endothelial Nitric Oxide Synthase by Hutchinson, Tarun E, Hu, Hanbo, Patel, Jawaharlal M

“…Cell penetrating peptides can be used as therapeutic agents via modulation of selective cell functions. Nitric oxide (NO) generated by vascular endothelial NO…”
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Thioredoxin priming prolongs lung allograft survival by promoting immune tolerance by Hu, Hanbo, Zhu, Xiaoyan, Joshi, Sunil, Lu, Li, Xia, Chang-Qing, Patel, Jawaharlal M

“…Tolerance to allograft antigen is the major challenge and final goal of transplant medicine. Our previous study demonstrated that thioredoxin-1 (Trx) priming…”
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Priming Donor Lungs With Thioredoxin-1 Attenuates Acute Allograft Injury in a Rat Model of Lung Transplantation by Hu, Hanbo, MD, Lu, Li, MD, PhD, Mu, Wei, MD, Johnson, Richard J., MD, Block, Edward R., MD, Patel, Jawaharlal M., PhD

“…Background Lung graft dysfunction and rejection are significant causes of morbidity and mortality in transplant recipients. Thioredoxin-1, a redox-regulatory…”
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Peptides modified by myristoylation activate eNOS in endothelial cells through Akt phosphorylation by Krotova, Karina, Hu, Hanbo, Xia, Shen‐Ling, Belayev, Leonid, Patel, Jawaharlal M, Block, Edward R, Zharikov, Sergey

“…1 Myristoylated pseudosubstrate of PKCζ (mPS) – a synthetic myristoylated peptide with a sequence (13 amino acids) mimicking the endogenous PKCζ…”
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Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin -1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor α-converting enzyme inhibitor, on the disposition of methotrexate: A transporter-based drug-drug interaction case study by GANG LUO, GARNER, C. Edwin, LEE, Frank W, GAN, Liang-Shang, HAO XIONG, HANBO HU, RICHARDS, Lauren E, BROUWER, Kim L. R, JINGWU DUAN, DECICCO, Carl P, MADUSKUIE, Thomas, SHEN, Helen

“…DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] is a potent human tumor necrosis…”
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Thioredoxin as a biomarker for graft rejection in lung transplant recipients by Patel, Jawaharlal M., Hu, Hanbo, Lu, Li, Deem, Amy, Akindipe, Olufemi, Brantly, Mark, Block, Edward R., Antony, Veena B., Baz, Maher A.

“…Abstract Primary graft dysfunction and rejection are common complications in lung transplant recipients. Increased expression of thioredoxin-1 (Trx), a 12-kDa…”
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Involvement of Calpain-Calpastatin in Cigarette Smoke-Induced Inhibition of Lung Endothelial Nitric Oxide Synthase by Cui, Zhaoqiang, Han, Zhaosheng, Li, Zhaozhong, Hu, Hanbo, Patel, Jawaharlal M, Antony, Veena, Block, Edward R, Su, Yunchao

“…We reported that cigarette smoke extract (CSE) causes decreases in the activity and expression of endothelial nitric oxide synthase (eNOS) and calpain activity…”
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A novel braided biodegradable stent for use in congenital heart disease: Short‐term results in porcine iliac artery by Sun, Jing, Sun, Kun, Bai, Kai, Chen, Sun, Wang, Fujun, Zhao, Fan, Hong, Nanchao, Hu, Hanbo

“…To evaluate the properties and efficacy of a novel braided biodegradable stent (BBS) consisting of poly (p‐dioxanone) (PPDO) and polycaprolactone (PCL) for…”
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Numerical simulation and experimental study on the compression performance of a double layer cross-lattice-core sandwich structure by Hu, Hanbo, Wang, Wensheng, Ning, Huijun, Liu, Bingxin

“…Lattice sandwich structures are widely used in many engineering fields for their excellent mechanical properties, such as aerospace, transportation,…”
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Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells by Zharikov, Sergey, Krotova, Karina, Hu, Hanbo, Baylis, Chris, Johnson, Richard J, Block, Edward R, Patel, Jawaharlal

“…Elevated levels of serum uric acid (UA) are commonly associated with primary pulmonary hypertension but have generally not been thought to have any causal…”
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Oversized composite braided biodegradable stents with post-dilatation for pediatric applications: mid-term results of a porcine study by Sun, Jing, Sun, Kun, Bai, Kai, Chen, Sun, Zhao, Fan, Wang, Fujun, Hong, Nanchao, Hu, Hanbo

“…Our aim was to apply a composite braided biodegradable stent (CBBS) made from poly p-dioxanone (PPDO) and polycaprolactone (PCL) as an alternative to metallic…”
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Self-expanding apical closure device for full-percutaneous closed-chest transapical valve procedures with large-sized introducer sheaths: first study in an animal model by Hong, Nanchao, Lu, Yanan, Hu, Hanbo, Sun, Jing, Sun, Kun, von Segesser, Ludwig Karl, Berdajs, Denis, Chen, Sun, Ferrari, Enrico

“…Abstract OBJECTIVES Available apical occluders do not fulfil requirements for full-percutaneous transapical valve procedures with large-sized introducer…”
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Novel peptide for attenuation of hypoxia-induced pulmonary hypertension via modulation of nitric oxide release and phosphodiesterase -5 activity by Hu, Hanbo, Zharikov, Sergey, Patel, Jawaharlal M.

“…► Peptide therapy attenuates hypoxia-induced pulmonary artery hypertension and vascular remodeling. ► The effect was found to be mediated by increased…”
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Neuroprotective effect of resveratrol prophylaxis on experimental retinal ischemic injury by Vin, Anita P., Hu, Hanbo, Zhai, Yougang, Von Zee, Cynthia L., Logeman, Andrew, Stubbs, Evan B., Perlman, Jay I., Bu, Ping

“…The purpose of the present study was to investigate whether systemically administered resveratrol can protect against acute retinal ischemic reperfusion…”
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Administration of recombinant human thioredoxin-1 significantly delays and prevents autoimmune diabetes in nonobese diabetic mice through modulation of autoimmunity by Chernatynskaya, Anna V., Looney, Benjamin, Hu, Hanbo, Zhu, Xiaoyan, Xia, Chang-Qing

“…Background Thioredoxin as a biological antioxidant plays an important role in regulating the redox system. The administration of recombinant thioredoxin has…”
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Thioredoxin Priming Prolongs Lung Allograft Survival by Promoting Immune Tolerance: e0124705 by Hu, Hanbo, Zhu, Xiaoyan, Joshi, Sunil, Lu, Li, Xia, Chang-Qing, Patel, Jawaharlal M

“…Tolerance to allograft antigen is the major challenge and final goal of transplant medicine. Our previous study demonstrated that thioredoxin-1 (Trx) priming…”
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Discovery of potent and selective PKC-θ inhibitors by Cywin, Charles L., Dahmann, Georg, Prokopowicz, Anthony S., Young, Erick R.R., Magolda, Ronald L., Cardozo, Mario G., Cogan, Derek A., DiSalvo, Darren, Ginn, John D., Kashem, Mohammed A., Wolak, John P., Homon, Carol A., Farrell, Thomas M., Grbic, Heather, Hu, Hanbo, Kaplita, Paul V., Liu, Lisa H., Spero, Denice M., Jeanfavre, Deborah D., O’Shea, Kathy M., White, Della M., Woska, Joseph R., Brown, Maryanne L.

“…An uHTS campaign was performed to identify selective inhibitors of PKC-θ. Initial triaging of the hit set based on selectivity and historical analysis led to…”
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