Search Results - "Hu, Haidai"

Structure and Function of Stator Units of the Bacterial Flagellar Motor by Santiveri, Mònica, Roa-Eguiara, Aritz, Kühne, Caroline, Wadhwa, Navish, Hu, Haidai, Berg, Howard C., Erhardt, Marc, Taylor, Nicholas M.I.

“…Many bacteria use the flagellum for locomotion and chemotaxis. Its bidirectional rotation is driven by a membrane-embedded motor, which uses energy from the…”
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Structural basis of torque generation in the bi-directional bacterial flagellar motor by Hu, Haidai, Santiveri, Mònica, Wadhwa, Navish, Berg, Howard C., Erhardt, Marc, Taylor, Nicholas M.I.

“…The flagellar stator unit is an oligomeric complex of two membrane proteins (MotA5B2) that powers bi-directional rotation of the bacterial flagellum…”
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Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit by Hu, Haidai, Popp, Philipp F., Santiveri, Mònica, Roa-Eguiara, Aritz, Yan, Yumeng, Martin, Freddie J. O., Liu, Zheyi, Wadhwa, Navish, Wang, Yong, Erhardt, Marc, Taylor, Nicholas M. I.

“…Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly motile bacteria responsible for various human diseases, the polar…”
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Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel by Nemecz, Ákos, Hu, Haidai, Fourati, Zaineb, Van Renterghem, Catherine, Delarue, Marc, Corringer, Pierre-Jean

“…The Gloeobacter violaceus ligand-gated ion channel (GLIC) has been extensively studied by X-ray crystallography and other biophysical techniques. This provided…”
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Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels by Fourati, Zaineb, Howard, Rebecca J., Heusser, Stephanie A., Hu, Haidai, Ruza, Reinis R., Sauguet, Ludovic, Lindahl, Erik, Delarue, Marc

“…Ion channel modulation by general anesthetics is a vital pharmacological process with implications for receptor biophysics and drug development. Functional…”
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Structure and mechanism of Zorya anti-phage defense system by Hu, Haidai, Hughes, Thomas C.D., Popp, Philipp F., Roa-Eguiara, Aritz, Martin, Freddie J.O., Rutbeek, Nicole R., Hendriks, Ivo Alexander, Payne, Leighton J., Yan, Yumeng, de Sousa, Victor Klein, Wang, Yong, Nielsen, Michael Lund, Berry, Richard M., Erhardt, Marc, Jackson, Simon A., Taylor, Nicholas M.I.

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Structural and Functional Studies Uncover Two Networks Stabilizing the Active Form of GLIC, a Bacterial Proton-Gated Pentameric Ion Channel by Hu, Haidai

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Structural dynamics and determinants of 2-aminoadenine specificity in DNA polymerase DpoZ of vibriophage ϕVC8 by Czernecki, Dariusz, Hu, Haidai, Romoli, Filippo, Delarue, Marc

“…Abstract All genetic information in cellular life is stored in DNA copolymers composed of four basic building blocks (ATGC-DNA). In contrast, a group of…”
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Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel by Hu, Haidai, Howard, Rebecca J., Bastolla, Ugo, Lindahl, Erik, Delarue, Marc

“…Pentameric ligand-gated ion channels (pLGICs) are allosteric receptors that mediate rapid electrochemical signal transduction in the animal nervous system…”
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Ion-driven rotary membrane motors: From structure to function by Martin, Freddie J.O., Santiveri, Mònica, Hu, Haidai, Taylor, Nicholas M.I.

“…Ion-driven membrane motors, essential across all domains of life, convert a gradient of ions across a membrane into rotational energy, facilitating diverse…”
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Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel by Hu, Haidai, Ataka, Kenichi, Menny, Anaïs, Fourati, Zaineb, Sauguet, Ludovic, Corringer, Pierre-Jean, Koehl, Patrice, Heberle, Joachim, Delarue, Marc

“…The pentameric ligand-gated ion channel (pLGIC) from Gloeobacter violaceus (GLIC) has provided insightful structure–function views on the permeation process…”
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Depicting protein structures as schematics by Markert, Jonathan, Luger, Karolin, Lee, Hayun, Hu, Haidai, Taylor, Nicholas M.I., Fernandez-Martinez, Javier, Rout, Michael, Alder, Nathan

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Structural Studies of the Gating Mechanism in a Pentameric Ligand-Gated Ion Channel Containing Two Additional N-Terminal Periplasmic Domains by Delarue, Marc H., Hu, Haidai, Howard, Rebecca J., Rovsnik, Urska, Hlioui, Sirine, Lindahl, Erik

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Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation by Hu, Haidai, Nemecz, Ákos, Van Renterghem, Catherine, Fourati, Zaineb, Sauguet, Ludovic, Corringer, Pierre-Jean, Delarue, Marc

“…Pentameric ligand-gated ion channels (pLGICs) constitute a widespread class of ion channels, present in archaea, bacteria, and eukaryotes. Upon binding of…”
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Structure of the type VI secretion phospholipase effector Tle1 provides insight into its hydrolysis and membrane targeting by Hu, Haidai, Zhang, Heng, Gao, Zengqiang, Wang, Dongqi, Liu, Guangfeng, Xu, Jianhua, Lan, Ke, Dong, Yuhui

“…A diverse superfamily of phospholipases consisting of the type VI lipase effectors Tle1–Tle5 secreted by the bacterial type VI secretion system (T6SS) have…”
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Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor by Hu, Haidai, Dong, Jiazhen, Liang, Deguang, Gao, Zengqiang, Bai, Lei, Sun, Rui, Hu, Hao, Zhang, Heng, Dong, Yuhui, Lan, Ke

“…The oncogenic herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) is known to encode four viral interferon regulatory factors (vIRF1 to -4) to subvert…”
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Uncommon Features of a Novel γ-Proteobacterial Pentameric Ligand-Gated Ion Channel Revealed by its Crystal Structure by Hu, HaiDai, Nemecz, Akos, Fourati, Zeineb, Corringer, Pierre-Jean, Delarue, Marc

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Elucidating Proton Sensitivity and Activation in the Gloeobacter Violaceus Ligand-Gated Ion Channel by Nemecz, Ákos, Fourati, Zaineb, Hu, Haidai, Corringer, Pierre-Jean, Delarue, Marc

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Structural Details of an Allosteric Mechanism for Bimodal Anesthetic Modulation of Pentameric Ligand-Gated Ion Channels by Howard, Rebecca J., Fourati, Zaineb, Heusser, Stephanie A., Hu, Haidai, Ruza, Reinis R., Sauguet, Ludovic, Lindahl, Erik, Delarue, Marc

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Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein by Zhang, Jiulong, Zhang, Heng, Gao, Zengqiang, Hu, Haidai, Dong, Cheng, Dong, Yu-Hui

“…•VgrG3C has inverting glycosyl hydrolase features adopting T4-lysozyme-like fold.•Oligomeric TsaB may play an important role in biological…”
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