Search Results - "Hu, Guanggan"

Role of Ferric Reductases in Iron Acquisition and Virulence in the Fungal Pathogen Cryptococcus neoformans by Saikia, Sanjay, Oliveira, Debora, Hu, Guanggan, Kronstad, James

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Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box by Kronstad, James W, Attarian, Rodgoun, Cadieux, Brigitte, Choi, Jaehyuk, D'Souza, Cletus A, Griffiths, Emma J, Geddes, Jennifer M. H, Hu, Guanggan, Jung, Won Hee, Kretschmer, Matthias, Saikia, Sanjay, Wang, Joyce

“…Key Points Cryptococcus neoformans is generally considered to be an opportunistic pathogen because of its tendency to infect immunocompromised individuals…”
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Loss of the putative Rab GTPase, Ypt7, impairs the virulence of Cryptococcus neoformans by Hu, Guanggan, Qu, Xianya, Bhalla, Kabir, Xue, Peng, Bakkeren, Erik, Lee, Christopher W J, Kronstad, James W

“…Small GTPases of the Rab family coordinate multiple membrane fusion and trafficking events in eukaryotes. In fungi, the Rab GTPase, Ypt7, plays a critical role…”
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Cryptococcus neoformans Requires the ESCRT Protein Vps23 for Iron Acquisition from Heme, for Capsule Formation, and for Virulence by Hu, Guanggan, Caza, Mélissa, Cadieux, Brigitte, Chan, Vivienne, Liu, Victor, Kronstad, James

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The Mannoprotein Cig1 Supports Iron Acquisition From Heme and Virulence in the Pathogenic Fungus Cryptococcus neoformans by Cadieux, Brigitte, Lian, Tianshun, Hu, Guanggan, Wang, Joyce, Biondo, Carmelo, Teti, Giuseppe, Liu, Victor, Murphy, Michael E. P., Creagh, A. Louise, Kronstad, James W.

“…Iron acquisition is critical for virulence of the human pathogenic fungus Cryptococcus neoformans. The cryptococcal transcript for the extracellular…”
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The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans by Attarian, Rodgoun, Hu, Guanggan, Sánchez-León, Eddy, Caza, Mélissa, Croll, Daniel, Do, Eunsoo, Bach, Horacio, Missall, Tricia, Lodge, Jennifer, Jung, Won Hee, Kronstad, James W

“…The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus In this study, we characterized…”
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The Sec1/Munc18 (SM) protein Vps45 is involved in iron uptake, mitochondrial function and virulence in the pathogenic fungus Cryptococcus neoformans by Caza, Mélissa, Hu, Guanggan, Nielson, Erik David, Cho, Minsu, Jung, Won Hee, Kronstad, James W

“…The battle for iron between invading microorganisms and mammalian hosts is a pivotal determinant of the outcome of infection. The pathogenic fungus,…”
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HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans by Jung, Won Hee, Saikia, Sanjay, Hu, Guanggan, Wang, Joyce, Fung, Carlen Ka-Yin, D'Souza, Cletus, White, Rick, Kronstad, James W

“…The fungal pathogen Cryptococcus neoformans is a major cause of illness in immunocompromised individuals such as AIDS patients. The ability of the fungus to…”
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Role of Ferroxidases in Iron Uptake and Virulence of Cryptococcus neoformans by Jung, Won Hee, Hu, Guanggan, Kuo, Wayne, Kronstad, James W

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The Novel J-Domain Protein Mrj1 Is Required for Mitochondrial Respiration and Virulence in Cryptococcus neoformans by Horianopoulos, Linda C, Hu, Guanggan, Caza, Mélissa, Schmitt, Kerstin, Overby, Peter, Johnson, James D, Valerius, Oliver, Braus, Gerhard H, Kronstad, James W

“…The opportunistic fungal pathogen must adapt to the mammalian environment to establish an infection. Proteins facilitating adaptation to novel environments,…”
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The interplay between electron transport chain function and iron regulatory factors influences melanin formation in Cryptococcus neoformans by Xue, Peng, Sánchez-León, Eddy, Hu, Guanggan, Lee, Christopher W J, Black, Braydon, Brisland, Anna, Li, Haohua, Jung, Won Hee, Kronstad, James W

“…Mitochondrial functions are critical for the ability of the fungal pathogen to cause disease. However, mechanistic connections between key functions such as…”
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Dnj1 Promotes Virulence in Cryptococcus neoformans by Maintaining Robust Endoplasmic Reticulum Homeostasis Under Temperature Stress by Horianopoulos, Linda C., Lee, Christopher W. J., Hu, Guanggan, Caza, Mélissa, Kronstad, James W.

“…The capacity of opportunistic fungal pathogens such as Cryptococcus neoformans to cause disease is dependent on their ability to overcome an onslaught of…”
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Loss of Opi3 causes a lipid imbalance that influences the virulence traits of Cryptococcus neoformans but not cryptococcosis by Lee, Christopher W J, Brisland, Anna, Qu, Xianya, Horianopoulos, Linda C, Hu, Guanggan, Mayer, François L, Kronstad, James W

“…The basidiomycete fungus is a useful model for investigating mechanisms of fungal pathogenesis in mammalian hosts. This pathogen is the causative agent of…”
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The monothiol glutaredoxin Grx4 influences thermotolerance, cell wall integrity, and Mpk1 signaling in Cryptococcus neoformans by Hu, Guanggan, Horianopoulos, Linda, Sánchez-León, Eddy, Caza, Mélissa, Jung, Wonhee, Kronstad, James W

“…Monothiol glutaredoxins are important regulators of iron homeostasis that play conserved roles in the sensing and trafficking of iron-sulfur clusters. We…”
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Proteasome inhibition as a therapeutic target for the fungal pathogen Cryptococcus neoformans by Caza, Mélissa, Santos, Daniel Assis, Burden, Elizabeth, Brisland, Anna, Hu, Guanggan, Kronstad, James W

“…The current therapeutic challenges for treating fungal diseases demand new approaches and new drugs. A promising strategy involves combination therapy with…”
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Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection by Hu, Guanggan, Cheng, Po-Yan, Sham, Anita, Perfect, John R, Kronstad, James W

“…The pathogenic fungus Cryptococcus neoformans generally initiates infection in mammalian lung tissue and subsequently disseminates to the brain. We performed…”
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A J Domain Protein Functions as a Histone Chaperone to Maintain Genome Integrity and the Response to DNA Damage in a Human Fungal Pathogen by Horianopoulos, Linda C, Lee, Christopher W J, Schmitt, Kerstin, Valerius, Oliver, Hu, Guanggan, Caza, Mélissa, Braus, Gerhard H, Kronstad, James W

“…Histone chaperoning ensures genomic integrity during routine processes such as DNA replication and transcription as well as DNA repair upon damage. Here, we…”
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Adaptation of Cryptococcus neoformans to Mammalian Hosts: Integrated Regulation of Metabolism and Virulence by Kronstad, Jim, Saikia, Sanjay, Nielson, Erik David, Kretschmer, Matthias, Jung, Wonhee, Hu, Guanggan, Geddes, Jennifer M. H, Griffiths, Emma J, Choi, Jaehyuk, Cadieux, Brigitte, Caza, Mélissa, Attarian, Rodgoun

“…The basidiomycete fungus Cryptococcus neoformans infects humans via inhalation of desiccated yeast cells or spores from the environment. In the absence of…”
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Involvement of Mrs3/4 in Mitochondrial Iron Transport and Metabolism in Cryptococcus neoformans by Choi, Yoojeong, Do, Eunsoo, Hu, Guanggan, Caza, Mélissa, Horianopoulos, Linda C, Kronstad, James W, Jung, Won Hee

“…Mitochondria play a vital role in iron uptake and metabolism in pathogenic fungi, and also influence virulence and drug tolerance. However, the regulation of…”
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Phosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans by Qu, Xianya, Bhalla, Kabir, Horianopoulos, Linda C, Hu, Guanggan, Alcázar Magaña, Armando, Foster, Leonard J, Roque da Silva, Leandro Buffoni, Kretschmer, Matthias, Kronstad, James W

“…There is an urgent need for new antifungal drugs to treat invasive fungal diseases. Unfortunately, the echinocandin drugs that are fungicidal against other…”
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