Search Results - "Hu, Fuqu"
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The hpRNA/RNAi Pathway Is Essential to Resolve Intragenomic Conflict in the Drosophila Male Germline
Published in Developmental cell (06-08-2018)“…Intragenomic conflicts are fueled by rapidly evolving selfish genetic elements, which induce selective pressures to innovate opposing repressive mechanisms…”
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Journal Article -
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RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana
Published in eLife (02-05-2017)“…RNA-induced silencing complex (RISC) is composed of miRNAs and AGO proteins. AGOs use miRNAs as guides to slice target mRNAs to produce truncated 5' and 3' RNA…”
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3
The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain
Published in Structure (London) (11-08-2010)“…RIG-I is a cytosolic sensor of viral RNA that plays crucial roles in the induction of type I interferons. The C-terminal domain (CTD) of RIG-I is responsible…”
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Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor
Published in Molecular cell (16-07-2015)“…Several terminal uridyltransferases (TUTases) are known to modulate small RNA biogenesis and/or function via diverse mechanisms. Here, we demonstrate that…”
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Journal Article -
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The mir-279/996 cluster represses receptor tyrosine kinase signaling to determine cell fates in the Drosophila eye
Published in Development (Cambridge) (01-04-2018)“…Photoreceptors in the crystalline eye are recruited by receptor tyrosine kinase (RTK)/Ras signaling mediated by Epidermal growth factor receptor (EGFR) and the…”
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Arabidopsis Argonaute10 Specifically Sequesters miR166/165 to Regulate Shoot Apical Meristem Development
Published in Cell (15-04-2011)“…The shoot apical meristem (SAM) comprises a group of undifferentiated cells that divide to maintain the plant meristem and also give rise to all shoot organs…”
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Journal Article -
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From Structure to Systems: High-Resolution, Quantitative Genetic Analysis of RNA Polymerase II
Published in Cell (15-08-2013)“…RNA polymerase II (RNAPII) lies at the core of dynamic control of gene expression. Using 53 RNAPII point mutants, we generated a point mutant epistatic…”
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Characterization of a TUTase/RNase complex required for Drosophila gametogenesis
Published in RNA (Cambridge) (01-03-2017)“…Post-transcriptional regulatory strategies that involve coupling between terminal uridyltransferase (TUTase) and exoribonuclease enzymes have recently been…”
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Journal Article -
9
A signaling-induced switch in dicer localization and function
Published in Developmental cell (08-12-2014)“…In this issue of Developmental Cell, Drake and colleagues (2014) report that Ras signaling results in Dicer phosphorylation, which induces its nuclear…”
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Functional and mechanistic insights of Arabidopis thaliana Argonaute10 and its cofactor RICE1 in RNA silencing
Published 2014“…Argonautes (AGOs) are central components in RNA-induced gene silencing complexes (RISCs) and control almost all aspects of developmental processes in…”
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Dissertation -
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Arabidopsis Argonaute 10 specifically sequesters miR166/165 to regulate shoot apical meristem development
Published in Cell (15-04-2011)“…The shoot apical meristem (SAM) comprises a group of undifferentiated cells that divide to maintain the meristem and also give rise to all plant shoot organs…”
Get full text
Journal Article