Search Results - "Hu, Fanghao"

Biological imaging of chemical bonds by stimulated Raman scattering microscopy by Hu, Fanghao, Shi, Lixue, Min, Wei

“…All molecules consist of chemical bonds, and much can be learned from mapping the spatiotemporal dynamics of these bonds. Since its invention a decade ago,…”
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Raman Imaging of Small Biomolecules by Shen, Yihui, Hu, Fanghao, Min, Wei

“…Imaging techniques greatly facilitate the comprehensive knowledge of biological systems. Although imaging methodology for biomacromolecules such as protein and…”
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Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms by Schiessl, Konstanze T., Hu, Fanghao, Jo, Jeanyoung, Nazia, Sakila Z., Wang, Bryan, Price-Whelan, Alexa, Min, Wei, Dietrich, Lars E. P.

“…Antibiotic efficacy can be antagonized by bioactive metabolites and other drugs present at infection sites. Pseudomonas aeruginosa , a common cause of…”
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Multiplexed live-cell profiling with Raman probes by Chen, Chen, Zhao, Zhilun, Qian, Naixin, Wei, Shixuan, Hu, Fanghao, Min, Wei

“…Single-cell multiparameter measurement has been increasingly recognized as a key technology toward systematic understandings of complex molecular and cellular…”
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Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR by Hu, Fanghao, Luo, Wenbin, Hong, Mei

“…The M2 protein of influenza viruses forms an acid-activated tetrameric proton channel. We used solid-state nuclear magnetic resonance spectroscopy to determine…”
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Ultra-bright Raman dots for multiplexed optical imaging by Zhao, Zhilun, Chen, Chen, Wei, Shixuan, Xiong, Hanqing, Hu, Fanghao, Miao, Yupeng, Jin, Tianwei, Min, Wei

“…Imaging the spatial distribution of biomolecules is at the core of modern biology. The development of fluorescence techniques has enabled researchers to…”
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9-Cyanopyronin probe palette for super-multiplexed vibrational imaging by Miao, Yupeng, Qian, Naixin, Shi, Lixue, Hu, Fanghao, Min, Wei

“…Multiplexed optical imaging provides holistic visualization on a vast number of molecular targets, which has become increasingly essential for understanding…”
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Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis by Gaschler, Michael M, Hu, Fanghao, Feng, Huizhong, Linkermann, Andreas, Min, Wei, Stockwell, Brent R

“…Ferroptosis is a form of nonapoptotic cell death characterized by the unchecked accumulation of lipid peroxides. Ferrostatin-1 and its analogs (ferrostatins)…”
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Live-Cell Bioorthogonal Chemical Imaging: Stimulated Raman Scattering Microscopy of Vibrational Probes by Wei, Lu, Hu, Fanghao, Chen, Zhixing, Shen, Yihui, Zhang, Luyuan, Min, Wei

“…Innovations in light microscopy have tremendously revolutionized the way researchers study biological systems with subcellular resolution. In particular,…”
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Optical mapping of biological water in single live cells by stimulated Raman excited fluorescence microscopy by Shi, Lixue, Hu, Fanghao, Min, Wei

“…Water is arguably the most common and yet least understood material on Earth. Indeed, the biophysical behavior of water in crowded intracellular milieu is a…”
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Membrane protein structure and dynamics from NMR spectroscopy by Hong, Mei, Zhang, Yuan, Hu, Fanghao

“…We review the current state of membrane protein structure determination using solid-state nuclear magnetic resonance (NMR) spectroscopy. Multidimensional…”
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Photoswitchable polyynes for multiplexed stimulated Raman scattering microscopy with reversible light control by Yang, Yueli, Bai, Xueyang, Hu, Fanghao

“…Optical imaging with photo-controllable probes has greatly advanced biological research. With superb chemical specificity of vibrational spectroscopy,…”
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NMR Detection of pH-Dependent Histidine–Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel by Hu, Fanghao, Schmidt-Rohr, Klaus, Hong, Mei

“…The acid-activated proton channel formed by the influenza M2 protein is important for the life cycle of the virus. A single histidine, His37, in the M2…”
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Vibrational Imaging of Glucose Uptake Activity in Live Cells and Tissues by Stimulated Raman Scattering by Hu, Fanghao, Chen, Zhixing, Zhang, Luyuan, Shen, Yihui, Wei, Lu, Min, Wei

“…Glucose is a ubiquitous energy source for most living organisms. Its uptake activity closely reflects cellular metabolic demand in various physiopathological…”
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A ratiometric Raman probe for live-cell imaging of hydrogen sulfide in mitochondria by stimulated Raman scattering by Zeng, Chen, Hu, Fanghao, Long, Rong, Min, Wei

“…Stimulated Raman Scattering (SRS) coupled with alkyne tags has been an emerging imaging technique to visualize small-molecule species with high sensitivity and…”
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Live-Cell Quantitative Imaging of Proteome Degradation by Stimulated Raman Scattering by Shen, Yihui, Xu, Fang, Wei, Lu, Hu, Fanghao, Min, Wei

“…Protein degradation is a regulatory process essential to cell viability and its dysfunction is implicated in many diseases, such as aging and…”
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Structure-activity-distribution relationship study of anti-cancer antimycin-type depsipeptides by Seidel, Jeremy, Miao, Yupeng, Porterfield, William, Cai, Wenlong, Zhu, Xuejun, Kim, Seong-Jong, Hu, Fanghao, Bhattarai-Kline, Santi, Min, Wei, Zhang, Wenjun

“…Small-molecule natural products have been an essential source of pharmaceuticals to treat human diseases, but very little is known about their behavior inside…”
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Author Correction: Ultra-bright Raman dots for multiplexed optical imaging by Zhao, Zhilun, Chen, Chen, Wei, Shixuan, Xiong, Hanqing, Hu, Fanghao, Miao, Yupeng, Jin, Tianwei, Min, Wei

“…A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22585-3…”
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Paramagnetic Cu(II) for Probing Membrane Protein Structure and Function: Inhibition Mechanism of the Influenza M2 Proton Channel by Su, Yongchao, Hu, Fanghao, Hong, Mei

“…Paramagnetic Cu(II) ions enhance nuclear spin relaxation in a distance-dependent fashion and can be used as a structural probe of proteins. Cu(II) can also…”
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Structure and Function of the Influenza A M2 Proton Channel by Cady, Sarah D, Luo, Wenbin, Hu, Fanghao, Hong, Mei

“…The M2 protein of influenza A viruses forms a tetrameric pH-activated proton-selective channel that is targeted by the amantadine class of antiviral drugs. Its…”
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