Search Results - "Hu, Eric Y."

Synaptic Efficacy as a Function of Ionotropic Receptor Distribution: A Computational Study by Allam, Sushmita L, Bouteiller, Jean-Marie C, Hu, Eric Y, Ambert, Nicolas, Greget, Renaud, Bischoff, Serge, Baudry, Michel, Berger, Theodore W

“…Glutamatergic synapses are the most prevalent functional elements of information processing in the brain. Changes in pre-synaptic activity and in the function…”
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Integrated Multiscale Modeling of the Nervous System: Predicting Changes in Hippocampal Network Activity by a Positive AMPA Receptor Modulator by Bouteiller, Jean-Marie C., Allam, Sushmita L., Hu, Eric Y., Greget, Renaud, Ambert, Nicolas, Keller, Anne Florence, Bischoff, Serge, Baudry, Michel, Berger, Theodore W.

“…One of the fundamental characteristics of the brain is its hierarchical organization. Scales in both space and time that must be considered when integrating…”
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A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model by Yant, Stephen R., Mulato, Andrew, Hansen, Derek, Tse, Winston C., Niedziela-Majka, Anita, Zhang, Jennifer R., Stepan, George J., Jin, Debi, Wong, Melanie H., Perreira, Jill M., Singer, Eric, Papalia, Giuseppe A., Hu, Eric Y., Zheng, Jim, Lu, Bing, Schroeder, Scott D., Chou, Kevin, Ahmadyar, Shekeba, Liclican, Albert, Yu, Helen, Novikov, Nikolai, Paoli, Eric, Gonik, Daniel, Ram, Renee R., Hung, Magdeleine, McDougall, William M., Brass, Abraham L., Sundquist, Wesley I., Cihlar, Tomas, Link, John O.

“…People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication…”
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Volterra representation enables modeling of complex synaptic nonlinear dynamics in large-scale simulations by Hu, Eric Y, Bouteiller, Jean-Marie C, Song, Dong, Baudry, Michel, Berger, Theodore W

“…Chemical synapses are comprised of a wide collection of intricate signaling pathways involving complex dynamics. These mechanisms are often reduced to simple…”
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Modeling Nonlinear Synaptic Dynamics: A Laguerre-Volterra Network Framework for Improved Computational Efficiency in Large Scale Simulations by Hu, Eric Y., Gene Yu, Dong Song, Jean-Marie Bouteiller, C., Theodore Berger, W.

“…Synapses are key components in signal transmission in the brain, often exhibiting complex non-linear dynamics. Yet, they are often crudely modelled as linear…”
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Clinical targeting of HIV capsid protein with a long-acting small molecule by Link, John O., Rhee, Martin S., Tse, Winston C., Zheng, Jim, Somoza, John R., Rowe, William, Begley, Rebecca, Chiu, Anna, Mulato, Andrew, Hansen, Derek, Singer, Eric, Tsai, Luong K., Bam, Rujuta A., Chou, Chien-Hung, Canales, Eda, Brizgys, Gediminas, Zhang, Jennifer R., Li, Jiayao, Graupe, Michael, Morganelli, Philip, Liu, Qi, Wu, Qiaoyin, Halcomb, Randall L., Saito, Roland D., Schroeder, Scott D., Lazerwith, Scott E., Bondy, Steven, Jin, Debi, Hung, Magdeleine, Novikov, Nikolai, Liu, Xiaohong, Villaseñor, Armando G., Cannizzaro, Carina E., Hu, Eric Y., Anderson, Robert L., Appleby, Todd C., Lu, Bing, Mwangi, Judy, Liclican, Albert, Niedziela-Majka, Anita, Papalia, Giuseppe A., Wong, Melanie H., Leavitt, Stephanie A., Xu, Yili, Koditek, David, Stepan, George J., Yu, Helen, Pagratis, Nikos, Clancy, Sheila, Ahmadyar, Shekeba, Cai, Terrence Z., Sellers, Scott, Wolckenhauer, Scott A., Ling, John, Callebaut, Christian, Margot, Nicolas, Ram, Renee R., Liu, Ya-Pei, Hyland, Rob, Sinclair, Gary I., Ruane, Peter J., Crofoot, Gordon E., McDonald, Cheryl K., Brainard, Diana M., Lad, Latesh, Swaminathan, Swami, Sundquist, Wesley I., Sakowicz, Roman, Chester, Anne E., Lee, William E., Daar, Eric S., Yant, Stephen R., Cihlar, Tomas

“…Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis 1…”
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Development of a detailed model of calcium dynamics at the postsynaptic spine of an excitatory synapse by Hu, Eric Y., Bouteiller, Jean-Marie C., Dong Song, Berger, Theodore W.

“…Postsynaptic calcium dynamics play a critical role in synaptic plasticity, but are often difficult to measure in experimental protocols due to their relatively…”
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The volterra functional series is a viable alternative to kinetic models for synaptic modeling -calibration and benchmarking by Hu, Eric Y., Bouteiller, Jean-Marie C., Dong Song, Berger, Theodore W.

“…Synaptic transmission is governed by a series of complex and highly nonlinear mechanisms and pathways in which the dynamics have a profound influence on the…”
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A comparison between direct and indirect measurements of neurotransmitter vesicle release dynamics: A computational study by Hu, Eric Y., Bouteiller, Jean-Marie C., Huang, Mike, Dong Song, Berger, Theodore

“…Presynaptic vesicular release of neurotransmitters is a stochastic process involving complex mechanisms triggered by an elevation of calcium concentration. The…”
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Modeling of the nervous system: From modulation of glutamatergic and gabaergic molecular dynamics to neuron spiking activity by Bouteiller, J-M C., Legendre, A., Allam, S. L., Ambert, N., Hu, E. Y., Greget, R., Keller, A. F., Pernot, F., Bischoff, S., Baudry, M., Berger, T. W.

“…One of the fundamental characteristics of the brain is its hierarchical and temporal organization: scales in both space and time must be considered to fully…”
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Paired-pulse stimulation at glutamatergic synapses - pre- and postsynaptic components by Bouteiller, J-M C, Allam, S L, Greget, R, Ambert, N, Hu, E Y, Bischoff, S, Baudry, M, Berger, T W

“…Paired-pulse stimulation is a standard protocol that has been used for decades to characterize dynamic systems: the differences in responses to two sequential…”
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Modeling of the nervous system: From molecular dynamics and synaptic modulation to neuron spiking activity by Bouteiller, Jean-Marie C., Allam, Sushmita L., Hu, Eric Y., Greget, Renaud, Ambert, Nicolas, Keller, Anne F., Pernot, Fabien, Bischoff, Serge, Baudry, Michel, Berger, Theodore W.

“…The brain is a perfect example of an integrated multi-scale system, as the complex interactions taking place at the molecular level regulate neuronal activity…”
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Synaptic Efficacy as a Function of Ionotropic Receptor Distribution: A Computational Study: e0140333 by Allam, Sushmita L, Bouteiller, Jean-Marie C, Hu, Eric Y, Ambert, Nicolas, Greget, Renaud, Bischoff, Serge, Baudry, Michel, Berger, Theodore W

“…Glutamatergic synapses are the most prevalent functional elements of information processing in the brain. Changes in pre-synaptic activity and in the function…”
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Digitizing Dunhuang Cultural Heritage: A User Evaluation of Mogao Cave Panorama Digital Library by Hu Xiao, Ho Eric M. Y., Qiao Chen

“…This study is a user evaluation on the usability of the Mogao Cave Panorama Digital Library (DL), aiming to measure its effectiveness from the users’…”
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Maximizing predictability of a bottom-up complex multi-scale model through systematic validation and multi-objective multi-level optimization by Bouteiller, Jean-Marie C., Zhuobo Feng, Onopa, Alexander, Huang, Mike, Hu, Eric Y., Somogyi, Endre, Baudry, Michel, Bischoff, Serge, Berger, Theodore W.

“…Computational models are mathematical representations meant to replicate the biological system they represent, as well as provide insights and predict the…”
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Integrated Multiscale Modeling of the Nervous System: Predicting Changes in Hippocampal Network Activity by a Positive AMPA Receptor Modulator: MULTISCALE MODELING AND ANALYSIS IN COMPUTATIONAL BIOLOGY AND MEDICINE: PART 1 by BOUTEILLER, Jean-Marie C, ALLAM, Sushmita L, HU, Eric Y, GREGET, Renaud, AMBERT, Nicolas, KELLER, Anne Florence, BISCHOFF, Serge, BAUDRY, Michel, BERGER, Theodore W

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Influence of ionotropic receptor location on their dynamics at glutamatergic synapses by Allam, Sushmita L., Bouteiller, J. C., Hu, Eric Y., Greget, R., Ambert, N., Bischoff, S., Baudry, M., Berger, T. W.

“…In this paper we study the effects of the location of ionotropic receptors, especially AMPA and NMDA receptors, on their function at excitatory glutamatergic…”
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