Suitable Calcineurin Inhibitor Concentrations for Liver Transplant Recipients in the Chinese Population

Abstract Aim The aim was to deduce suitable calcineurin inhibitor concentrations for the Chinese liver transplantation population. Methods We retrospectively studied 97 liver transplant recipients who displayed stable liver and renal function. No grafts were obtained from prisoners, procurements wer...

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Published in:	Transplantation proceedings Vol. 43; no. 5; pp. 1751 - 1753
Main Authors:	Chen, Y.B, Li, S.D, Ju, B.L, Shi, X.J, Lu, F, Hu, D.K, Yu, C.H, Dong, J.H
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01-06-2011 Elsevier
Subjects:	Adult Biological and medical sciences Calcineurin Inhibitors China Cyclosporine - administration & dosage Cyclosporine - blood Drug Monitoring Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - blood Liver Transplantation Male Medical sciences Middle Aged Retrospective Studies Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tacrolimus - administration & dosage Tacrolimus - blood Tissue, organ and graft immunology Asia China Human Medicine Calcineurin inhibitor Treatment Digestive system Surgery Liver Graft Transplantation Concentration Homotransplantation
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Summary:	Abstract Aim The aim was to deduce suitable calcineurin inhibitor concentrations for the Chinese liver transplantation population. Methods We retrospectively studied 97 liver transplant recipients who displayed stable liver and renal function. No grafts were obtained from prisoners, procurements were performed with donor consent conforming to international ethics regulations. At 3, 6, and 12 months, we increased the concentrations and doses of calcineurin inhibitors as well as the values of alanine transaminase and serum creatinine. Results Twenty-eight recipients received cyclosporine and 69 tacrolimus. The mean cyclosporine daily dosages were 203 ± 62 mg at 3, 188 ± 55 mg at 6, and 173 ± 52 mg at 12 months, the tacrolimus daily dosages were 3.08 ± 0.98, 2.82 ± 0.98, and 2.58 ± 0.93 mg, respectively. The corresponding mean cyclosporine peak concentrations (C2 ) were 806 ± 322 ng/mL, 681 ± 206 ng/mL, and 644 ± 190 ng/mL and the mean tacrolimus trought concentrations (C0 ) 6.61 ± 3.02 ng/mL, 5.85 ± 2.44 ng/mL, and 5.22 ± 2.33 ng/mL, respectively. In both groups, transaminases and serum creatinine were stable over time. Conclusions An individualized immunosuppressive regimen for the local population is necessary. We delayed calcineurin inhibitors with subsequent low-dose mycophenolate mofetil plus minimized calcineurin inhibitors, which seemed to be nephropreotective and safe for Chinese liver transplantation patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2010.11.025