Search Results - "Hu, Burong"

Unrepaired clustered DNA lesions induce chromosome breakage in human cells by Asaithamby, Aroumougame, Hu, Burong, Chen, David J

“…Clustered DNA damage induced by ionizing radiation is refractory to repair and may trigger carcinogenic events for reasons that are not well understood. Here,…”
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Both Complexity and Location of DNA Damage Contribute to Cellular Senescence Induced by Ionizing Radiation by Zhang, Xurui, Ye, Caiyong, Sun, Fang, Wei, Wenjun, Hu, Burong, Wang, Jufang

“…Persistent DNA damage is considered as a main cause of cellular senescence induced by ionizing radiation. However, the molecular bases of the DNA damage and…”
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The DDR-related gene signature with cell cycle checkpoint function predicts prognosis, immune activity, and chemoradiotherapy response in lung adenocarcinoma by Li, Quan, Zhang, Pan, Hu, Huixiao, Huang, Hang, Pan, Dong, Mao, Guangyun, Hu, Burong

“…Abstract Background As a DNA surveillance mechanism, cell cycle checkpoint has recently been discovered to be closely associated with lung adenocarcinoma…”
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Ilomastat contributes to the survival of mouse after irradiation via promoting the recovery of hematopoietic system by Zhao, Baoquan, Li, Xiaoman, Li, Xingzhou, Quan, Dongqin, Zhang, Fang, Hu, Burong

“…Ilomastat, a broad-spectrum inhibitor of matrix metalloproteinases (MMPs), has drawn attentions for its function in alleviating radiation damage. However, the…”
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Effects of Ionizing Radiation on Three-Dimensional Human Vessel Models: Differential Effects According to Radiation Quality and Cellular Development by Grabham, Peter, Hu, Burong, Sharma, Preety, Geard, Charles

“…Little is known about the effects of space radiation on the human body. There are a number of potential chronic and acute effects, and one major target for…”
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FANCD2 influences replication fork processes and genome stability in response to clustered DSBs by Zhu, Jiayun, Su, Fengtao, Mukherjee, Shibani, Mori, Eiichiro, Hu, Burong, Asaithamby, Aroumougame

“…Fanconi Anemia (FA) is a cancer predisposition syndrome and the factors defective in FA are involved in DNA replication, DNA damage repair and tumor…”
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miR-29b-3p Increases Radiosensitivity in Stemness Cancer Cells via Modulating Oncogenes Axis by Pan, Dong, Du, Yarong, Li, Rong, Shen, Aihua, Liu, Xiaodong, Li, Chuanyuan, Hu, Burong

“…Radioresistance conferred by cancer stem cells (CSCs) is the principal cause of the failure of cancer radiotherapy. Eradication of CSCs is a prime therapeutic…”
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The time and spatial effects of bystander response in mammalian cells induced by low dose radiation by Hu, Burong, Wu, Lijun, Han, Wei, Zhang, Leilei, Chen, Shaopeng, Xu, An, Hei, Tom K., Yu, Zengliang

“…Bystander effects induced by low dose of ionizing radiation have been shown to widely exist in many cell types and may have a significant impact on radiation…”
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Reprogramming mediated radio-resistance of 3D-grown cancer cells by Xue, Gang, Ren, Zhenxin, Grabham, Peter W., Chen, Yaxiong, Zhu, Jiayun, Du, Yarong, Pan, Dong, Li, Xiaoman, Hu, Burong

“…In vitro 3D growth of tumors is a new cell culture model that more closely mimics the features of the in vivo environment and is being used increasingly in the…”
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LET-Dependent Low Dose and Synergistic Inhibition of Human Angiogenesis by Charged Particles: Validation of miRNAs that Drive Inhibition by Wuu, Yen-Ruh, Hu, Burong, Okunola, Hazeem, Paul, Amber M., Blaber, Elizabeth A., Cheng-Campbell, Margareth, Beheshti, Afshin, Grabham, Peter

“…Space radiation inhibits angiogenesis by two mechanisms depending on the linear energy transfer (LET). Using human 3D micro-vessel models, blockage of the…”
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Transforming growth factor-β-induced protein (TGFBI) suppresses mesothelioma progression through the Akt/mTOR pathway by GENGYUN WEN, MEI HONG, HEI, Tom K, BINGYAN LI, WUPENG LIAO, CHENG, Simon K, BURONG HU, CALAF, Gloria M, PING LU, PARTRIDGE, Michael A, JIAN TONG

“…As an uncommon cancer, mesothelioma is very hard to treat with a low average survival rate owing to its usual late detection and being highly invasive. The…”
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No significant level of inheritable interchromosomal aberrations in the progeny of bystander primary human fibroblasts after alpha particle irradiation by Hu, Burong, Zhu, Jiayun, Zhou, Hongning, Hei, Tom K.

“…► Genomic instability occurred in the progeny of the bystander cells. ► No inheritable interchromosomal aberration in the progeny of the bystander cells. ►…”
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Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture by Asaithamby, Aroumougame, Hu, Burong, Delgado, Oliver, Ding, Liang-Hao, Story, Michael D., Minna, John D., Shay, Jerry W., Chen, David J.

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Increased susceptibility of human small airway epithelial cells to apoptosis after long term arsenate treatment by Wen, Gengyun, Partridge, Michael A., Calaf, Gloria M., Meador, Jarah A., Hu, Burong, Echiburú-Chau, Carlos, Hong, Mei, Hei, Tom K.

“…Inorganic arsenic (arsenate and arsenite) are well known human carcinogens. Apoptosis is a normal biological process that is involved in regulating cell…”
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When DNA damage responses meet tumor immunity: From mechanism to therapeutic opportunity by Pan, Dong, Wang, Qi, Shen, Aihua, Qi, Zhihao, Zheng, Chunfu, Hu, Burong

“…DNA damage is a prevalent phenomenon in the context of cancer progression. Evidence suggests that DNA damage responses (DDR) are pivotal in overcoming tumor…”
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A feedback regulation between miR-145 and DNA methyltransferase 3b in prostate cancer cell and their responses to irradiation by Xue, Gang, Ren, Zhenxin, Chen, Yaxiong, Zhu, Jiayun, Du, Yarong, Pan, Dong, Li, Xiaoman, Hu, Burong

“…Abstract It is believed that epigenetic modification plays roles in cancer initiation and progression. Both microRNA and DNA methyltransferase are epigenetic…”
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Suppression of innate immune signaling molecule, MAVS, reduces radiation-induced bystander effect by Jia, Rong, Chen, Yaxiong, Jia, Cong, Hu, Burong, Du, Yarong

“…Mitochondrial antiviral signaling (MAVS) protein, located in the mitochondrial out-membrane, is necessary for IFN-beta induction and IFN-stimulated gene…”
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Effects of a novel HDAC6-selective inhibitor’s radiosensitization on cancer cells by Hu, Huixiao, Wang, Qi, Zhang, Yuni, Yang, Shuhua, Shen, Aihua, Yan, Junfang, Zhao, Denggao, Hu, Burong

“…Background The radiation sensitivity of tumor cells is a critical determinant of their therapeutic response to radiotherapy. Histone deacetylase 6 (HDAC6),…”
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Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy by Mo, Hualong, Liu, JieYing, Su, Zhengxi, Zhao, Deng-Gao, Ma, Yan-Yan, Zhang, Kun, Wang, Qi, Fu, Chun, Wang, Yao, Chen, Meiwan, Hu, Burong

“…Conventional chemotherapy, especially with natural anticancer drugs, usually suffers from poor bioavailability and low tumor accumulation. To address these…”
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Identification of a Novel Gene Signature with DDR and EMT Difunctionalities for Predicting Prognosis, Immune Activity, and Drug Response in Breast Cancer by Zhang, Pan, Li, Quan, Zhang, Yuni, Wang, Qianqian, Yan, Junfang, Shen, Aihua, Hu, Burong

“…Breast cancer, with an overall poor clinical prognosis, is one of the most heterogeneous cancers. DNA damage repair (DDR) and epithelial-mesenchymal transition…”
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