L-shaped association of plasma low-density lipoprotein cholesterol with atrial fibrillation recurrence after catheter ablation: a prospective cohort study

L-shaped association of plasma low-density lipoprotein cholesterol with atrial fibrillation recurrence after catheter ablation: a prospective cohort study

The association between plasma low-density lipoprotein cholesterol (LDL-C) and atrial fibrillation (AF) recurrence after catheter ablation remains unclear. We aimed to assess the relationship between preprocedural LDL-C and the AF recurrence in patients undergoing catheter ablation. The cohort study...

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Published in:Scientific reports Vol. 14; no. 1; p. 28434
Main Authors: Zou, Huiming, Huang, Qianghui, Huang, Qianwei, Hu, Bingchao, He, Wenhao, Xia, Zirong, Duan, Zongcai, Li, Guoqing, Hu, Jianxin, Hu, Jinzhu, Zhan, Biming
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 18-11-2024
Nature Publishing Group
Subjects:
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692/699/75
Ablation
Cardiac arrhythmia
Catheters
Cholesterol
Cohort analysis
Fibrillation
Humanities and Social Sciences
Low density lipoprotein
Medical instruments
multidisciplinary
Nonlinear systems
Radiofrequency ablation
Science
Science (multidisciplinary)
Radiofrequency catheter ablation
Recurrence
Atrial fibrillation
Cohort study
Low-density lipoprotein cholesterol
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Summary:The association between plasma low-density lipoprotein cholesterol (LDL-C) and atrial fibrillation (AF) recurrence after catheter ablation remains unclear. We aimed to assess the relationship between preprocedural LDL-C and the AF recurrence in patients undergoing catheter ablation. The cohort study consecutively included AF patients who underwent de novo catheter ablation between April 2021 and January 2023 in the Second Affiliated Hospital of Nanchang University in Jiangxi Province, China. Patients were divided into quartiles based on their baseline fasting LDL-C level (Q1-Q4). Multivariable Cox proportional hazards models were used to evaluate the relationship between LDL-C and AF recurrence. Our analysis included the use of a generalized additive model and smooth curve fitting (penalized spline method), and two-piecewise Cox proportional hazards models, to address the nonlinearity between preprocedural LDL-C and AF recurrence. A total of 482 AF patients with de novo catheter ablation were enrolled, with a median follow-up period of 15.00 months, AF recurrence occurred in 96 (19.92%) patients. The relationship between preprocedural LDL-C and AF recurrence after ablation presented as an L-shape, and the inflection point for the curve was found at the LDL-C level of 3.20 mmol/L (Log likelihood ratio P = 0.031). The hazard ratios (HR) [(95% confidence intervals (CI)] for AF recurrence were 0.50 (0.33–0.74) and 2.11 (0.76–5.89) to the left and right of the inflection point, respectively. Lower LDL-C level is associated with increased AF recurrence risk after catheter ablation were consistent across all subgroups.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-79836-8