Search Results - "Hu, Anling"

A novel iheyamine A derivative L42 suppresses acute myeloid leukemia via dual regulation of the PI3K/AKT/FOXO3a axis and TNF signaling pathway by Dinghuan, Wang, Yi, Kuang, Jianzhi, Tian, Wenfei, Wei, Chunlin, Wang, Anling, Hu, Zhixu, He, Ben-David, Yaacov, Sheng, Liu, Xiaoyan, Yang, Xiao, Xiao

“…Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies and the development of new drugs is crucial for the treatment of this lethal…”
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Xiaochaihutang Improves the Cortical Astrocyte Edema in Thioacetamide-Induced Rat Acute Hepatic Encephalopathy by Activating NRF2 Pathway by Jia, Weiyi, Liu, Jiajia, Hu, Rui, Hu, Anling, Tang, Weiwei, Li, Lijuan, Li, Jin

“…Oxidative stress induced by high ammonia, which leads to astrocyte edema, is the key to acute hepatic encephalopathy (AHE). Nuclear factor erythroid 2-related…”
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The role of calcium-sensing receptor in ginsenoside Rg1 promoting reendothelialization to inhibit intimal hyperplasia after balloon injury by Xu, Shangfu, Hu, Anling, Chen, Jiameng, Shuai, Zhiqin, Liu, Taotao, Deng, Jiang, Li, Lisheng, Gong, Qihai, He, Zhixu, Yu, Limei

“…Calcium-sensing receptor (CaSR) is a G protein-coupled receptor, widely distributed in various tissues, including vascular endothelial cells and smooth muscle…”
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FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression by Wang, Jie, Wang, Chunlin, Hu, Anling, Yu, Kunlin, Kuang, Yi, Gajendran, Babu, Zacksenhaus, Eldad, Sample, Klarke Michael, Xiao, Xiao, Liu, Wuling, Ben-David, Yaacov

“…FLI1 is an oncogenic transcription factor that promotes diverse malignancies through mechanisms that are not fully understood. Herein, FLI1 is shown to…”
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Lovastatin inhibits erythroleukemia progression through KLF2-mediated suppression of MAPK/ERK signaling by Gao, Jian, Hu, Jifen, Yu, Fang, Wang, Chunlin, Sheng, Danmei, Liu, Wuling, Hu, Anling, Yu, Kunling, Xiao, Xiao, Kuang, Yi, Zacksenhaus, Eldad, Gajendran, Babu, Ben-David, Yaacov

“…Lovastatin, an HMG-CoA inhibitor and an effective cholesterol lowering drug, exhibits anti-neoplastic activity towards several types of cancer, although the…”
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ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes by Yu, Fang, Gajendran, Babu, Wang, Ning, Sample, Klarke M, Liu, Wuling, Wang, Chunlin, Hu, Anling, Zacksenhaus, Eldad, Hao, Xiaojiang, Ben-David, Yaacov

“…Abstract Background Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or…”
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FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome by Wang, Chunlin, Sample, Klarke M, Gajendran, Babu, Kapranov, Philipp, Liu, Wuling, Hu, Anling, Zacksenhaus, Eldad, Li, Yanmei, Hao, Xiaojiang, Ben-David, Yaacov

“…Wiskott-Aldrich Syndrome, WAS/WAVE, is a rare, X-linked immune-deficiency disease caused by mutations in the gene, which together with its homolog, N- ,…”
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Involvement of stromal cell-derived factor-1α (SDF-1α), stem cell factor (SCF), fractalkine (FKN) and VEGF in TSG protection against intimal hyperplasia in rat balloon injury by Hu, Anling, Huang, Juan, Li, Shiyue, Gao, Yang, Wu, Li, Deng, Jiang, Liu, Jie, Gong, Qihai, Li, Lisheng, Xu, Shangfu

“…[Display omitted] •TSG inhibited intimal hyperplasia in rat common carotid artery balloon injury.•TSG reduced the expression of SCF/c-kit, SDF-1α/CXCR4 and…”
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A natural acylphloroglucinol triggered antiproliferative possessions in HEL cells by impeding STAT3 signaling and attenuating angiogenesis in transgenic zebrafish model by Hu, Mi, Varier, Krishnapriya M., Li, Zhicao, Qin, Xujie, Rao, Qing, Song, Jingrui, Hu, Anling, Hang, Yubing, Yuan, Chunmao, Gajendran, Babu, Shu, Liping, Wen, Min, Li, Yanmei, Liu, Haiyang

“…Leukemia is responsible for a reason of death, globally. Even though there are several treatment regimens available in the clinics against this disease, a…”
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An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells by Varier, Krishnapriya M, Dhandapani, Hemavathi, Liu, Wuling, Song, Jialei, Wang, Chunlin, Hu, Anling, Ben-David, Yaacov, Shen, Xiangchun, Li, Yanmei, Gajendran, Babu

“…Immunotherapeutic treatments are gaining attention due to their effective anti-tumor response. Particularly, the revolution of immune checkpoint inhibitors…”
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UM171 cooperates with PIM1 inhibitors to restrict HSC expansion markers and suppress leukemia progression by Hu, Anling, Gao, Jian, Varier, Krishnapriya M., Gajendran, Babu, Jiang, Fei, Liu, Wuling, Wang, Chunlin, Xiao, Xiao, Li, Yanmei, Zacksenhaus, Eldad, Ali, Sajjad, Ben-David, Yaacov

“…The pyrimido-indole derivative UM171 promotes human Hematopoietic Stem Cells Expansion (HSCE), but its impact on leukemia is not known. Herein, we show in a…”
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UM171 suppresses breast cancer progression by inducing KLF2 by Ran, Xiaojuan, Hu, Anling, Kuang, Yi, Wang, Chunlin, Liu, Wuling, Xiao, Xiao, Zacksenhaus, Eldad, Yu, Xiangdi, Ben-David, Yaacov

“…Purpose Breast cancer is the most frequent cancer in women with significant death rate. Morbidity is associated with drug resistance and metastasis…”
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Ginsenoside Rg1 prevents vascular intimal hyperplasia involved by SDF-1α/CXCR4, SCF/c-kit and FKN/CX3CR1 axes in a rat balloon injury by Hu, Anling, Shuai, Zhiqin, Liu, Jiajia, Huang, Bo, Luo, Yunmei, Deng, Jiang, Liu, Jie, Yu, Limei, Li, Lisheng, Xu, Shangfu

“…Panax ginseng C. A. Mey. is a traditional tonic that has been used for thousands of years, and has positive effects on vascular diseases. Ginsenoside Rg1…”
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Naringenin attenuates carotid restenosis in rats after balloon injury through its anti-inflammation and anti-oxidative effects via the RIP1-RIP3-MLKL signaling pathway by Huang, Bo, Hu, Pei, Hu, Anling, Li, Yingying, Shi, Wanlan, Huang, Juan, Jiang, Qingsong, Xu, Shangfu, Li, Lisheng, Wu, Qin

“…Vascular restenosis has been proved as the major drawback of percutaneous coronary interventions, which is characterized by neointimal hyperplasia. Naringenin…”
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A critical ETV4/Twist1/Vimentin axis in Ha-RAS-induced aggressive breast cancer by Liu, Wuling, Gajendran, Babu, Sample, Klarke M., Wang, Chunlin, Hu, Anling, Chen, Beiling, Li, Yanmei, Zacksenhaus, Eldad, Ben-David, Yaacov

“…RAS oncogenes are major drivers of diverse types of cancer. However, they are largely not druggable, and therefore targeting critical downstream pathways and…”
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A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux by Xiao, Xiao, Chung, Philip. E.D., Xu, Mei, Hu, Anling, Ju, Yangju, Yang, Xinmei, Song, Jialei, Song, Jingrui, Wang, Chunlin, Zacksenhaus, Eldad, Liu, Sheng, He, Zhixu, Ben-David, Yaacov

“…[Display omitted] Breast cancer is the most common malignancy among women worldwide. As conventional therapies are only partially successful in eradicating…”
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FLI1 regulates inflammation-associated genes to accelerate leukemogenesis by Chen, Beiling, Sheng, Danmei, Wang, Chunlin, Liu, Wuling, Hu, Anling, Xiao, Xiao, Gajendran, Babu, Gao, Jian, Hu, Jifen, Sample, Klarke M., Zacksenhaus, Eldad, Ben-David, Yaacov

“…Inflammation plays a critical role in cancer initiation and progression, and is induced by inflammatory factors that are direct target of oncogenes and tumor…”
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An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation by Wang, Chunlin, Hu, Maoting, Yu, Kunlin, Liu, Wuling, Hu, Anling, Kuang, Yi, Huang, Lei, Gajendran, Babu, Zacksenhaus, Eldad, Xiao, Xiao, Ben-David, Yaacov

“…During hematopoiesis, megakaryocytic erythroid progenitors (MEPs) differentiate into megakaryocytic or erythroid lineages in response to specific…”
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FLI1 accelerates leukemogenesis through transcriptional regulation of pyruvate kinase-L/R and other glycolytic genes by Sheng, Danmei, Chen, Beiling, Wang, Chunlin, Xiao, Xiao, Hu, Anling, Liu, Wuling, Kuang, Yi, Sample, Klarke M., Zacksenhaus, Eldad, Gajendran, Babu, Pan, Weidong, Ben-David, Yaacov

“…In cancer cells, multiple oncogenes and tumor suppressors control glycolysis to sustain rapid proliferation. The ETS-related transcription factor Fli1 plays a…”
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Integrating UPLC-HR-MS/MS, Network Pharmacology, and Experimental Validation to Uncover the Mechanisms of Jin’gan Capsules against Breast Cancer by Qiu, Jianfei, Zhang, Zhiyin, Hu, Anling, Zhao, Peng, Wei, Xuenai, Song, Hui, Yang, Jue, Li, Yanmei

“…In the theory of traditional Chinese medicine (TCM), “liver-qi” stagnation and heat-induced toxicity represent the main etiologies of breast cancer. Recently,…”
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