Search Results - "Hsu, T.A"

279 Discovery of multiple kinases inhibitors, DBPR114, as the novel anti-cancer agent by Hsieh, H.P, Kuo, C.C, Chiu, J.J, Hsu, T.A, Yeh, T.K, Chen, C.T

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Anti-HCV activities of selective polyunsaturated fatty acids by Leu, Guang-Zhou, Lin, Tiao-Yin, Hsu, John T.A

“…HCV infection can lead to chronic infectious hepatitis disease with serious sequelae. Interferon-α, or its PEGylated form, plus ribavirin is the only treatment…”
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1110 POSTER BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-proliferative Activity in P-gp170 (MDRI)-mediated VX680-resistant Cancer Cells in Vitro and in Vivo by Hsieh, H.P, Cheung, C.H.A, Lin, W.H, Hsu, T.A, Coumar, M.S, Chao, Y.S, Chang, J.Y

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The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes by Yao, Hsien-Tsung, Chang, Yi-Wei, Lan, Shih-Jung, Chen, Chiung-Tong, Hsu, John T.A., Yeh, Teng-Kuang

“…The inhibitory effect of saturated fatty acids (SFAs): palmitic acid (PA), stearic acid (SA) and polyunsaturated fatty acids (PUFAs): linoleic acid (LA),…”
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310 (PB298): Synergistic Anti-Tumor Effects of the Novel HDAC Inhibitor, ABT-301, with Immune Checkpoint Inhibitors in Colorectal Cancer Through Regulation of Immune Response and Anti-Angiogenesis by Tan, K.T., Lin, M.C., Hsu, T.A., Chang, C.F., Chang, S.M., Lin, C.T.

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Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells by Chen, Chia-Nan, Huang, Hsin-Hsiu, Wu, Chia-Li, Lin, Coney P.C, Hsu, John T.A, Hsieh, Hsing-Pang, Chuang, Shuang-En, Lai, Gi-Ming

“…Abstract Isocostunolide is a sesquiterpene lactone isolated from the roots of Inula helenium . Its chemical structure was determined by NMR and FAB-MS spectra…”
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Two-temperature dilute-acid prehydrolysis of hardwood xylan using a percolation process by Torget, R, Hsu, T.A

“…A novel two-temperature dilute-acid prehydrolysis of hybrid poplar xylan that exploits the xylan biphasic kinetics at moderate temperatures is described. A…”
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Effects of co-expressing chaperone BiP on functional antibody production in the baculovirus system by Hsu, T A, Eiden, J J, Bourgarel, P, Meo, T, Betenbaugh, M J

“…The assembly pathway of the insect cell Spodoptera frugiperda (Sf-9) was engineered to include expression of the murine chaperone immunoglobulin heavy chain…”
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Cooperator selection and industry assignment in supply chain network with line balancing technology by Che, Zhen-Guo, Che, Z.H., Hsu, T.A.

“…Losses from cooperator delivery delay may greatly undermine the supply chain network performance leading to losses in the increased business cost. This paper…”
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Inhibition of authentic hepatitis C virus replication by sodium stibogluconate by Yeh, Chau-Ting, Hwang, Der-Ren, Lai, Hsin-Yu, Hsu, John T.A

“…Using a hepatitis C virus (HCV) subgenomic RNA replicon system, drugs currently being used to treat other human diseases were examined for their antiviral…”
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Mycotoxin Patulin Suppresses Innate Immune Responses by Mitochondrial Dysfunction and p62/Sequestosome-1-dependent Mitophagy by Tsai, Wan-Ting, Lo, Yin-Chiu, Wu, Ming-Sian, Li, Chia-Yang, Kuo, Yi-Ping, Lai, Yi-Hui, Tsai, Yu, Chen, Kai-Chieh, Chuang, Tsung-Hsien, Yao, Chun-Hsu, Lee, Jinq-Chyi, Hsu, Li-Chung, Hsu, John T.-A., Yu, Guann-Yi

“…Innate immune responses are important for pathogen elimination and adaptive immune response activation. However, excess inflammation may contribute to…”
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Anti-Influenza Drug Discovery: Structure−Activity Relationship and Mechanistic Insight into Novel Angelicin Derivatives by Yeh, Jiann-Yih, Coumar, Mohane Selvaraj, Horng, Jim-Tong, Shiao, Hui-Yi, Kuo, Fu-Ming, Lee, Hui-Ling, Chen, In-Chun, Chang, Chun-Wei, Tang, Wen-Fang, Tseng, Sung-Nain, Chen, Chi-Jene, Shih, Shin-Ru, Hsu, John T.-A, Liao, Chun-Chen, Chao, Yu-Sheng, Hsieh, Hsing-Pang

“…By using a cell-based high throughput screening campaign, a novel angelicin derivative 6a was identified to inhibit influenza A (H1N1) virus induced cytopathic…”
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Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification by Ke, Yi-Yu, Singh, Vivek Kumar, Coumar, Mohane Selvaraj, Hsu, Yung Chang, Wang, Wen-Chieh, Song, Jen-Shin, Chen, Chun-Hwa, Lin, Wen-Hsing, Wu, Szu-Huei, Hsu, John T. A., Shih, Chuan, Hsieh, Hsing-Pang

“…The inhibition of FMS-like tyrosine kinase 3 (FLT3) activity using small-molecule inhibitors has emerged as a target-based alternative to traditional…”
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Synergistic Inhibition of Enterovirus 71 Replication by Interferon and Rupintrivir by Hung, Hui-Chen, Wang, Hsiang-Ching, Shih, Shin-Ru, Teng, I-Fang, Tseng, Ching-Ping, Hsu, John T.-A.

“…Background. Entero virus 71 (EV71) can cause severe diseases and even lead to death in children. There is no vaccine or specific antiviral therapy to prevent…”
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Extracellular HSP90α Induces MyD88-IRAK Complex-Associated IKKα/β-NF-κB/IRF3 and JAK2/TYK2-STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization by Fan, Chi-Shuan, Chen, Chia-Chi, Chen, Li-Li, Chua, Kee Voon, Hung, Hui-Chen, Hsu, John T-A, Huang, Tze-Sing

“…M2-polarization and the tumoricidal to tumor-promoting transition are commonly observed with tumor-infiltrating macrophages after interplay with cancer cells…”
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Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self‐interaction by Wu, Ming‐Jhan, Ke, Po‐Yuan, Hsu, John T.‐A., Yeh, Chau‐Ting, Horng, Jim‐Tong

“…Summary The non‐structural protein 4B (NS4B) of the hepatitis C virus (HCV) is an endoplasmic reticulum (ER) membrane protein comprising two consecutive…”
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Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening by Wu, Jian-Sung, Lin, Shu-Yu, Liao, Fang-Yu, Hsiao, Wen-Chi, Lee, Lung-Chun, Peng, Yi-Hui, Hsieh, Chia-Ling, Wu, Mine-Hsine, Song, Jen-Shin, Yueh, Andrew, Chen, Chun-Hwa, Yeh, Shiu-Hwa, Liu, Chia-Yeh, Lin, Shu-Yi, Yeh, Teng-Kuang, Hsu, John T.-A., Shih, Chuan, Ueng, Shau-Hua, Hung, Ming-Shiu, Wu, Su-Ying

“…A structure-based virtual screening strategy, comprising homology modeling, ligand–support binding site optimization, virtual screening, and structure…”
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Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity by Sarvagalla, Sailu, Singh, Vivek Kumar, Ke, Yi-Yu, Shiao, Hui-Yi, Lin, Wen-Hsing, Hsieh, Hsing-Pang, Hsu, John T. A., Coumar, Mohane Selvaraj

“…Furanopyrimidine 1 (IC 50  = 273 nM, LE = 0.36, LELP = 10.28) was recently identified by high-throughput screening (HTS) of an in-house library (125,000…”
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Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design by Chang, Chun-Feng, Lin, Wen-Hsing, Ke, Yi-Yu, Lin, Yih-Shyan, Wang, Wen-Chieh, Chen, Chun-Hwa, Kuo, Po-Chu, Hsu, John T.A., Uang, Biing-Jiun, Hsieh, Hsing-Pang

“…Aurora kinases have emerged as important anticancer targets so that there are several inhibitors have advanced into clinical study. Herein, we identified novel…”
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Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development by Liu, Chia-Lin, Hung, Hui-Chen, Lo, Shou-Chen, Chiang, Ching-Hui, Chen, I-Jung, Hsu, John T.-A., Hou, Ming-Hon

“…Nucleoprotein (NP) is the most abundant type of RNA-binding viral protein in influenza A virus–infected cells and is necessary for viral RNA transcription and…”
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