Search Results - "Hsu, Stephen I."

Racial and Genetic Factors in IgA Nephropathy by Hsu, Stephen I.-Hong, MD, PhD

“…Summary Racial and ethnic variations in the incidence of IgA nephropathy (IgAN) could imply both genetic and environmental influences that exist in a complex…”
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DTC genetic testing companies fail transparency prescriptions by Lewis, Norman P., Treise, Debbie, Hsu, Stephen I., Allen, William L., Kang, Hannah

“…In 2007, the American Society of Human Genetics issued recommendations for what the new and largely self-regulating industry offering genetic tests directly to…”
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Renal cell apoptosis and proliferation may be linked to nuclear factor– κB activation and expression of inducible nitric oxide synthase in patients with lupus nephritis by Zheng, Ling, Sinniah, Raja, Hsu, Stephen I-Hong

“…The mechanism of renal cell apoptosis involves transcriptional activation of the inducible nitric oxide synthase ( iNOS) gene by nuclear factor (NF)- κB. The…”
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CRM1-mediated Nuclear Export Is Required for 26 S Proteasome-dependent Degradation of the TRIP-Br2 Proto-oncoprotein by Cheong, Jit Kong, Gunaratnam, Lakshman, Hsu, Stephen I-Hong

“…Overexpression of the proto-oncogene TRIP-Br2 (SERTAD2) has been shown to induce E2F activity and promote tumorigenesis, whereas ablation of TRIP-Br2 arrests…”
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Evidence from the Oxford Classification cohort supports the clinical value of subclassification of focal segmental glomerulosclerosis in IgA nephropathy by Bellur, Shubha S, Lepeytre, Fanny, Vorobyeva, Olga, Troyanov, Stéphan, Cook, H Terence, Roberts, Ian S D

“…Focal segmental glomerulosclerosis (FSGS) is a common finding in IgA nephropathy (IgAN). Here we assessed FSGS lesions in the Oxford Classification patient…”
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TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors by Cheong, Jit Kong, Gunaratnam, Lakshman, Zang, Zhi Jiang, Yang, Christopher M, Sun, Xiaoming, Nasr, Susan L, Sim, Khe Guan, Peh, Bee Keow, Rashid, Suhaimi Bin Abdul, Bonventre, Joseph V, Salto-Tellez, Manuel, Hsu, Stephen I

“…Members of the TRIP-Br/SERTAD family of mammalian transcriptional coregulators have recently been implicated in E2F-mediated cell cycle progression and…”
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Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism by Wegman, Martin P, Guo, Michael H, Bennion, Douglas M, Shankar, Meena N, Chrzanowski, Stephen M, Goldberg, Leslie A, Xu, Jinze, Williams, Tiffany A, Lu, Xiaomin, Hsu, Stephen I, Anton, Stephen D, Leeuwenburgh, Christiaan, Brantly, Mark L

“…Caloric restriction has consistently been shown to extend life span and ameliorate aging-related diseases. These effects may be due to diet-induced reactive…”
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The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults by Coppo, Rosanna, Troyanov, Stéphan, Camilla, Roberta, Hogg, Ronald J., Cattran, Daniel C., Terence Cook, H., Feehally, John, Roberts, Ian S.D., Amore, Alessandro, Alpers, Charles E., Barratt, Jonathan, Berthoux, Francois, Bonsib, Stephen, Bruijn, Jan A., D'Agati, Vivette, D'Amico, Giuseppe, Emancipator, Steven N., Emma, Francesco, Ferrario, Franco, Fervenza, Fernando C., Florquin, Sandrine, Fogo, Agnes B., Geddes, Colin C., Groene, Hermann J., Haas, Mark, Herzenberg, Andrew M., Hill, Prue A., Hsu, Stephen I., Charles Jennette, J., Joh, Kensuke, Julian, Bruce A., Kawamura, Tetsuya, Lai, Fernand M., Li, Lei S., Li, Philip K., Liu, Zhi H., Mezzano, Sergio, Paolo Schena, F., Tomino, Yasuhiko, Walker, Patrick D., Wang, Haiyan, Weening, Jan J., Yoshikawa, Norishige, Zhang, Hong

“…To study the predictive value of biopsy lesions in IgA nephropathy in a range of patient ages we retrospectively analyzed the cohort that was used to derive a…”
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Should MD–PhD Programs Encourage Graduate Training in Disciplines Beyond Conventional Biomedical or Clinical Sciences? by O’Mara, Ryan J, Hsu, Stephen I, Wilson, Daniel R

“…The goal of MD–PhD training programs is to produce physician–scientists with unique capacities to lead the future biomedical research workforce. The current…”
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Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels by PENNEY, Kathryn L, SCHUMACHER, Fredrick R, HSU, Stephen I, KRAFT, Peter, MUCCI, Lorelei A, SESSO, Howard D, JINGMA, YUXINNIU, JITKONGCHEONG, HUNTER, David J, STAMPFER, Meir J

“…Genome-wide association studies have identified genetic markers in kallikrein-related peptidase 3 (KLK3) associated with prostate cancer. However, some of…”
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Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance by Liew, Chong Wee, Boucher, Jeremie, Cheong, Jit Kong, Vernochet, Cecile, Koh, Ho-Jin, Mallol, Cristina, Townsend, Kristy, Langin, Dominique, Kawamori, Dan, Hu, Jiang, Tseng, Yu-Hua, Hellerstein, Marc K, Farmer, Stephen R, Goodyear, Laurie, Doria, Alessandro, Blüher, Matthias, Hsu, Stephen I-Hong, Kulkarni, Rohit N

“…TRIP-Br2 –null mice are resistant to obesity and insulin resistance and have higher energy expenditure because of increased thermogenesis and oxidative…”
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Exploiting the TRIP-Br family of cell cycle regulatory proteins as chemotherapeutic drug targets in human cancer by Zang, Zhi Jiang, Sim, Khe Guan, Cheong, Jit Kong, Yang, Christopher Maolin, Yap, Chui Sun, I-Hong Hsu, Stephen

“…TRIP-Br1 and TRIP-Br2 are potent cell growth promoting factors that function as components of the E2F1/DP1 transcription complex to integrate positive growth…”
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TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1 by Hsu, Stephen I-Hong, Yang, Christopher Maolin, Sim, Khe Guan, Hentschel, Dirk M., O'Leary, Eileen, Bonventre, Joseph V.

“…We report the isolation of TRIP‐Br1, a transcriptional regulator that interacts with the PHD‐bromodomain of co‐repressors of Krüppel‐associated box…”
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Risk factors for proteinuria in a large, multiracial, southeast Asian population by RAMIREZ, Sylvia Paz B, MCCLELLAN, William, PORT, Friedrich K, HSU, Stephen I-Hong

“…The factors associated with proteinuria were examined in a large multiracial Asian population participating in a screening program aimed at the early detection…”
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In situ glomerular expression of activated NF-κB in human lupus nephritis and other non-proliferative proteinuric glomerulopathy by LING ZHENG, SINNIAH, Raja, HSU, Stephen I-Hong

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The CtBP2 co‐repressor is regulated by NADH‐dependent dimerization and possesses a novel N‐terminal repression domain by Thio, Sharon S. C., Bonventre, Joseph V., Hsu, Stephen I‐Hong

“…The C‐terminal binding protein 2 (CtBP2) is a 48 kDa phosphoprotein reported to function as a co‐ repressor for a growing list of transcriptional repressors…”
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Biopsy‐Proved Acute Tubulointerstitial Nephritis and Toxic Epidermal Necrolysis Associated with Vancomycin by Hsu, Stephen I‐Hong

“…A 70‐year‐old man receiving vancomycin for a methicillin‐resistant Staphylococcus aureus (MRSA) abscess developed a drug‐induced hypersensitivity reaction with…”
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Evidence for genetic factors in the development and progression of IgA nephropathy by Hsu, Stephen I-Hong, Ramirez, Sylvia B., Winn, Michelle P., Bonventre, Joseph V., Owen, William F.

“…Evidence for genetic factors in the development and progression of IgA nephropathy. IgA nephropathy (IgAN) is the most common glomerulonephritis in the world…”
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Downregulation of Bcl-2 by podocytes is associated with progressive glomerular injury and clinical indices of poor renal prognosis in human IgA nephropathy by OIU, Lian-Oun, SINNIAH, Raja, HSU, Stephen I-Hong

“…Bcl-2 defines a new class of proto-oncogenes that block cell death without promoting cell proliferation. To elucidate the role of Bcl-2 in the development of…”
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Role of differential and cell type-specific expression of cell cycle regulatory proteins in mediating progressive glomerular injury in human IgA nephropathy by Qiu, Lian-Qun, Sinniah, Raja, Hsu, Stephen I-H

“…The activities of cell cycle regulatory proteins have been reported to be associated with the development of pathological lesions in glomerulonephritis. To…”
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