Search Results - "Hsu, Margaret C"

Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists by Perner, Richard J., Koenig, John R., DiDomenico, Stanley, Gomtsyan, Arthur, Schmidt, Robert G., Lee, Chih-Hung, Hsu, Margaret C., McDonald, Heath A., Gauvin, Donna M., Joshi, Shailen, Turner, Teresa M., Reilly, Regina M., Kym, Philip R., Kort, Michael E.

“…The synthesis and structure–activity relationships of a series of 5-monosubstituted and 4,5-disubstituted 2-arylaminooxazoles as novel antagonists of the…”
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Synthetic 3-O-Methylmannose-Containing Polysaccharides (sMMPs):  Design and Synthesis by Hsu, Margaret C, Lee, Jinhwa, Kishi, Yoshito

“…With the hope of mimicking the chemical and biological properties of natural 3-O-methylmannose-containing polysaccharides (MMPs), synthetic…”
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New Practical Synthesis of Indazoles via Condensation of o-Fluorobenzaldehydes and Their O-Methyloximes with Hydrazine by Lukin, Kirill, Hsu, Margaret C, Fernando, Dilinie, Leanna, M. Robert

“…The reaction of o-fluorobenzaldehydes and their O-methyloximes with hydrazine has been developed as a new practical synthesis of indazoles. Utilization of the…”
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Synthesis of the Quinolone ABT-492:  Crystallizations for Optimal Processing by Haight, Anthony R, Ariman, Sema Z, Barnes, David M, Benz, Nancy J, Gueffier, Francoix X, Henry, Rodger F, Hsu, Margaret C, Lee, Elaine C, Morin, Larry, Pearl, Kurt B, Peterson, Matthew J, Plata, Daniel J, Willcox, David R

“…ABT-492 has been under development at Abbott Laboratories as a quinolone antibiotic. A convergent syntheses was utilized to prepare the compound on a…”
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Synthetic 3-O-Methylmannose-Containing Polysaccharides (sMMPs):  Design and Synthesis by Hsu, Margaret C, Lee, Jinhwa, Kishi, Yoshito

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Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102 by Lukin, Kirill, Hsu, Margaret C, Chambournier, Gilles, Kotecki, Brian, Venkatramani, C. J, Leanna, M. Robert

“…A highly efficient asymmetric synthesis of TRPV1 antagonist ABT-102 was developed and successfully demonstrated on a multi-kilogram scale. This process…”
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A Scaleable Synthesis of Fiduxosin by Haight, Anthony R, Bailey, Anne E, Baker, William S, Cain, Michael H, Copp, Richard R, DeMattei, John A, Ford, Kelley L, Henry, Rodger F, Hsu, Margaret C, Keyes, Robert F, King, Steven A, McLaughlin, Maureen A, Melcher, Laura M, Nadler, William R, Oliver, Patricia A, Parekh, Shyamal I, Patel, Hemant H, Seif, Louis S, Staeger, Mike A, Wayne, Gregory S, Wittenberger, Steven J, Zhang, Weijiang

“…Fiduxosin (1) has been under development at Abbott Laboratories for the treatment of benign prostatic hyperplasia. A convergent strategy required methodologies…”
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Chlorination at the 8-Position of a Functionalized Quinolone and the Synthesis of Quinolone Antibiotic ABT-492 by Barnes, David M, Christesen, Alan C, Engstrom, Kenneth M, Haight, Anthony R, Hsu, Margaret C, Lee, Elaine C, Peterson, Matthew J, Plata, Daniel J, Raje, Prasad S, Stoner, Eric J, Tedrow, Jason S, Wagaw, Seble

“…The total synthesis of quinolone antibiotic ABT-492 has been achieved in 67% yield over nine steps from 2,4,5-trifluorobenzoic acid. The highlights of this…”
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Synthesis of Erythromycin Derivatives via the Olefin Cross-Metathesis Reaction by Hsu, Margaret C, Junia, Adam J, Haight, Anthony R, Zhang, Weijiang

“…Olefin cross metathesis (CM) was applied to the synthesis of 6-O-substituted erythromycin derivatives. The reactions were catalyzed by transition metal…”
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Palladium-catalyzed coupling of alkynes with alcohols and carboxylic acids by Zhang, Weijiang, Haight, Anthony R., Hsu, Margaret C.

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