Search Results - "Hsu, L"
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The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
Published in Cancer and metastasis reviews (01-12-2016)“…Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660 women in the USA will be diagnosed with breast cancer in 2016. Breast…”
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2
Quantification of flexoelectricity in PbTiO3/SrTiO3 superlattice polar vortices using machine learning and phase-field modeling
Published in Nature communications (13-11-2017)“…Flexoelectricity refers to electric polarization generated by heterogeneous mechanical strains, namely strain gradients, in materials of arbitrary crystal…”
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3
Observation of room-temperature polar skyrmions
Published in Nature (London) (01-04-2019)“…Complex topological configurations are fertile ground for exploring emergent phenomena and exotic phases in condensed-matter physics. For example, the recent…”
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4
Improving seismic performance of framed structures with steel curved dampers
Published in Engineering structures (01-01-2017)“…•New curved damper design was proposed to improve performance of frame structures.•Effective equation for curved damper strength evaluation was…”
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5
A Submillimeter Perspective on the GOODS Fields (SUPER GOODS). I. An Ultradeep SCUBA-2 Survey of the GOODS-N
Published in The Astrophysical journal (10-03-2017)“…Abstract In this first paper in the SUPER GOODS series on powerfully star-forming galaxies in the two GOODS fields, we present a deep SCUBA-2 survey of the…”
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6
Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1
Published in Oncogene (24-08-2017)“…Hypoxia plays a critical role during the evolution of malignant cells and tumour microenvironment (TME).Tumour-derived exosomes contain informative microRNAs…”
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Mechanisms Controlling PD-L1 Expression in Cancer
Published in Molecular cell (07-11-2019)“…The engagement of programmed cell death protein 1 (PD-1; encoded by the PDCD1 gene) receptor expressed on activated T cells and its ligand, programmed…”
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A Submillimeter Perspective on the GOODS Fields (SUPER GOODS). III. A Large Sample of ALMA Sources in the GOODS-S
Published in The Astrophysical journal (01-10-2018)“…We analyze the >4 sources in the most sensitive 100 arcmin2 area (rms < 0.56 mJy) of a SCUBA-2 850 m survey of the GOODS-S and present the 75 band-7 ALMA…”
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9
Brace performance with steel curved dampers and amplified deformation mechanisms
Published in Engineering structures (15-11-2018)“…•New A-Brace design that adopted steel curved damper with amplified deformation for performance improvement was proposed.•Effective equation to evaluate the…”
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10
Directly Placed Restorative Materials: Review and Network Meta-analysis
Published in Journal of Dental Research (01-06-2016)“…For restoring cavitated dental lesions, whether carious or not, a large number of material combinations are available. We aimed to systematically review and…”
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The X-ray luminosity function of active galactic nuclei in the redshift interval z=3-5
Published in Monthly notices of the Royal Astronomical Society (21-10-2015)“…We combine deep X-ray survey data from the Chandra observatory and the wide-area/shallow XMM-XXL field to estimate the active galactic nuclei (AGN) X-ray…”
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12
Controlling the SARS-CoV-2 spike glycoprotein conformation
Published in Nature structural & molecular biology (01-10-2020)“…The coronavirus (CoV) spike (S) protein, involved in viral–host cell fusion, is the primary immunogenic target for virus neutralization and the current focus…”
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13
Dielectric Screening of Excitons and Trions in Single-Layer MoS2
Published in Nano letters (08-10-2014)“…Photoluminescence (PL) properties of single-layer MoS2 are indicated to have strong correlations with the surrounding dielectric environment. Blue shifts of up…”
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14
Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel
Published in Science (American Association for the Advancement of Science) (01-03-2019)“…Transient receptor potential melastatin member 8 (TRPM8) is a calcium ion (Ca )-permeable cation channel that serves as the primary cold and menthol sensor in…”
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15
Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS
Published in Molecular cell (05-12-2019)“…The COMPASS (complex of proteins associated with Set1) complex represents the prototype of the SET1/MLL family of methyltransferases that controls gene…”
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The impact of multidrug resistance in healthcare-associated and nosocomial Gram-negative bacteraemia on mortality and length of stay: cohort study
Published in Clinical microbiology and infection (01-05-2012)“…Multidrug-resistant Gram-negative bacteria (MDR-GNB) are an emerging public health threat. Accurate estimates of their clinical impact are vital for justifying…”
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Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
Published in Nature communications (05-02-2021)“…The two T cell inhibitory receptors PD-1 and TIM-3 are co-expressed during exhausted T cell differentiation, and recent evidence suggests that their crosstalk…”
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TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis
Published in The Journal of clinical investigation (15-04-2021)“…Immune checkpoint blockade therapy has demonstrated promising clinical outcomes for multiple cancer types. However, the emergence of resistance as well as…”
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19
On the representation of effective stress for computing hemolysis
Published in Biomechanics and modeling in mechanobiology (01-06-2019)“…Hemolysis is a major concern in blood-circulating devices, which arises due to hydrodynamic loading on red blood cells from ambient flow environment. Hemolysis…”
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PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression
Published in Clinical cancer research (15-07-2017)“…To explore whether a cross-talk exists between PARP inhibition and PD-L1/PD-1 immune checkpoint axis, and determine whether blockade of PD-L1/PD-1 potentiates…”
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