Search Results - "Hsu, Henry H"

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study by Butowski, Nicholas, Colman, Howard, De Groot, John F, Omuro, Antonio M, Nayak, Lakshmi, Wen, Patrick Y, Cloughesy, Timothy F, Marimuthu, Adhirai, Haidar, Sam, Perry, Arie, Huse, Jason, Phillips, Joanna, West, Brian L, Nolop, Keith B, Hsu, Henry H, Ligon, Keith L, Molinaro, Annette M, Prados, Michael

“…The colony stimulating factor 1 receptor (CSF1R) ligands, CSF1 and interleukin-34, and the KIT ligand, stem cell factor, are expressed in glioblastoma (GB)…”
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Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor by Tap, William D, Wainberg, Zev A, Anthony, Stephen P, Ibrahim, Prabha N, Zhang, Chao, Healey, John H, Chmielowski, Bartosz, Staddon, Arthur P, Cohn, Allen Lee, Shapiro, Geoffrey I, Keedy, Vicki L, Singh, Arun S, Puzanov, Igor, Kwak, Eunice L, Wagner, Andrew J, Von Hoff, Daniel D, Weiss, Glen J, Ramanathan, Ramesh K, Zhang, Jiazhong, Habets, Gaston, Zhang, Ying, Burton, Elizabeth A, Visor, Gary, Sanftner, Laura, Severson, Paul, Nguyen, Hoa, Kim, Marie J, Marimuthu, Adhirai, Tsang, Garson, Shellooe, Rafe, Gee, Carolyn, West, Brian L, Hirth, Peter, Nolop, Keith, van de Rijn, Matt, Hsu, Henry H, Peterfy, Charles, Lin, Paul S, Tong-Starksen, Sandra, Bollag, Gideon

“…The authors developed a novel CSF1R inhibitor, PLX3397, and conducted a phase 1 study. An extension cohort of 23 patients with tenosynovial giant-cell tumor…”
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Long‐term outcomes of pexidartinib in tenosynovial giant cell tumors by Gelderblom, Hans, Wagner, Andrew J., Tap, William D., Palmerini, Emanuela, Wainberg, Zev A., Desai, Jayesh, Healey, John H., Sande, Michiel A. J., Bernthal, Nicholas M., Staals, Eric L., Peterfy, Charles G., Frezza, Anna Maria, Hsu, Henry H., Wang, Qiang, Shuster, Dale E., Stacchiotti, Silvia

“…Background The objective of this study was to report on the long‐term effects of pexidartinib on tenosynovial giant cell tumor (TGCT). Methods This was a…”
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Randomized Study of Adding Inhaled Iloprost to Existing Bosentan in Pulmonary Arterial Hypertension by McLaughlin, Vallerie V, Oudiz, Ronald J, Frost, Adaani, Tapson, Victor F, Murali, Srinivas, Channick, Richard N, Badesch, David B, Barst, Robyn J, Hsu, Henry H, Rubin, Lewis J

“…Small, open-label studies suggest that combinations of existing therapies may be effective for pulmonary arterial hypertension (PAH). To evaluate the safety…”
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Cardioprotection by the adiponectin receptor agonist ALY688 in a preclinical mouse model of heart failure with reduced ejection fraction (HFrEF) by Cho, Sungji, Dadson, Keith, Sung, Hye Kyoung, Ayansola, Oyeronke, Mirzaesmaeili, Ali, Noskovicova, Nina, Zhao, Yimu, Cheung, Krisco, Radisic, Milica, Hinz, Boris, Sater, Ali A. Abdul, Hsu, Henry H., Lopaschuk, Gary D., Sweeney, Gary

“…Adiponectin has been shown to mediate cardioprotective effects and levels are typically reduced in patients with cardiometabolic disease. Hence, there has been…”
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Patient-reported Symptoms of Tenosynovial Giant Cell Tumors by Gelhorn, Heather L., PhD, Tong, Sandra, MD, McQuarrie, Kelly, BS, Vernon, Christina, MPH, Hanlon, Jennifer, MPH, Maclaine, Grant, BMedSc, MBBS, MEc, MA, Lenderking, William, PhD, Ye, Xin, PhD, MS, Speck, Rebecca M., PhD, MPH, Lackman, Richard D., MD, Bukata, Susan V., MD, Healey, John H., MD, Keedy, Vicki L., MD, MSCI, Anthony, Stephen P., DO, Wagner, Andrew J., MD, PhD, Von Hoff, Daniel D., MD, Singh, Arun S., MD, Becerra, Carlos R., MD, Hsu, Henry H., MD, Lin, Paul S., MD, MBA, Tap, William D., MD

“…Abstract Purpose Tenosynovial giant cell tumor (TGCT), a rare locally aggressive neoplasm of the synovium of joints and tendon sheaths, is associated with…”
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The adiponectin‐derived peptide ALY688 protects against the development of metabolic dysfunction‐associated steatohepatitis by Huang, Zhe, Sung, Hye Kyoung, Yan, Xingqun, He, Shiyu, Jin, Leigang, Wang, Qin, Wu, Xuerui, Hsu, Henry H., Pignalosa, Angelica, Crawford, Kathryn, Sweeney, Gary, Xu, Aimin

“…Metabolic dysfunction‐associated steatohepatitis (MASH) is the severe form of non‐alcoholic fatty liver disease which has a high potential to progress to…”
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Development of a non-invasive bioassay for adiponectin target engagement in mice by Tang, Jialing, Lei, Yubin, Pignalosa, Angelica, Hsu, Henry H., Abdul-Sater, Ali A., Sweeney, Gary

“…Adiponectin-based therapeutic strategies are promising for managing metabolic diseases and reducing inflammation, prompting the development of adiponectin…”
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Recombinant interferon-γ1b as adjunctive therapy for AIDS-related acute cryptococcal meningitis by PAPPAS, Peter G, BUSTAMANTE, Beatriz, TICONA, Eduardo, HAMILL, Richard J, JOHNSON, Philip C, REBOLI, Annette, ABERG, Judith, HASBUN, Rodrigo, HSU, Henry H

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The measurement of physical functioning among patients with Tenosynovial Giant Cell Tumor (TGCT) using the Patient-Reported Outcomes Measurement Information System (PROMIS) by Gelhorn, Heather L., Ye, Xin, Speck, Rebecca M., Tong, Sandra, Healey, John H., Bukata, Susan V., Lackman, Richard D., Murray, Lindsey, Maclaine, Grant, Lenderking, William R., Hsu, Henry H., Lin, Paul S., Tap, William D.

“…Background Tenosynovial giant cell tumor (TGCT), a rare, locally aggressive neoplasm of the synovium of joints and tendon sheaths, is associated with joint…”
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Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial by Tap, William D, Gelderblom, Hans, Palmerini, Emanuela, Desai, Jayesh, Bauer, Sebastian, Blay, Jean-Yves, Alcindor, Thierry, Ganjoo, Kristen, Martín-Broto, Javier, Ryan, Christopher W, Thomas, David M, Peterfy, Charles, Healey, John H, van de Sande, Michiel, Gelhorn, Heather L, Shuster, Dale E, Wang, Qiang, Yver, Antoine, Hsu, Henry H, Lin, Paul S, Tong-Starksen, Sandra, Stacchiotti, Silvia, Wagner, Andrew J

“…Tenosynovial giant cell tumour (TGCT), a rare, locally aggressive neoplasm, overexpresses colony-stimulating factor 1 (CSF1). Surgery is standard with no…”
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A novel blood-based bioassay to monitor adiponectin signaling by Lone, Abdul Hadee, Tang, Jialing, Pignalosa, Angelica, Hsu, Henry H., Abdul-Sater, Ali A., Sweeney, Gary

“…[Display omitted] •Using ALY688, we establish a non-invasive bioassay for screening adiponectin action.•In blood sample from mice treated with the…”
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Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397 by Smith, Catherine C, Zhang, Chao, Lin, Kimberly C, Lasater, Elisabeth A, Zhang, Ying, Massi, Evan, Damon, Lauren E, Pendleton, Matthew, Bashir, Ali, Sebra, Robert, Perl, Alexander, Kasarskis, Andrew, Shellooe, Rafe, Tsang, Garson, Carias, Heidi, Powell, Ben, Burton, Elizabeth A, Matusow, Bernice, Zhang, Jiazhong, Spevak, Wayne, Ibrahim, Prabha N, Le, Mai H, Hsu, Henry H, Habets, Gaston, West, Brian L, Bollag, Gideon, Shah, Neil P

“…Tyrosine kinase domain mutations are a common cause of acquired clinical resistance to tyrosine kinase inhibitors (TKI) used to treat cancer, including the…”
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The slow-release adiponectin analog ALY688-SR modifies early-stage disease development in the D2. mdx mouse model of Duchenne muscular dystrophy by Bellissimo, Catherine A, Gandhi, Shivam, Castellani, Laura N, Murugathasan, Mayoorey, Delfinis, Luca J, Thuhan, Arshdeep, Garibotti, Madison C, Seo, Yeji, Rebalka, Irena A, Hsu, Henry H, Sweeney, Gary, Hawke, Thomas J, Abdul-Sater, Ali A, Perry, Christopher G R

“…Fibrosis is associated with respiratory and limb muscle atrophy in Duchenne muscular dystrophy (DMD). Current standard of care partially delays the progression…”
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Results from Phase I Extension Study Assessing Pexidartinib Treatment in Six Cohorts with Solid Tumors including TGCT, and Abnormal CSF1 Transcripts in TGCT by Tap, William D, Singh, Arun S, Anthony, Stephen Patrick, Sterba, Mike, Zhang, Chao, Healey, John H, Chmielowski, Bartosz, Cohn, Allen Lee, Shapiro, Geoffrey I, Keedy, Vicki L, Wainberg, Zev A, Puzanov, Igor, Cote, Gregory M, Wagner, Andrew J, Braiteh, Fadi, Sherman, Eric, Hsu, Henry H, Peterfy, Charles, Gelhorn, Heather L, Ye, Xin, Severson, Paul, West, Brian L, Lin, Paul S, Tong-Starksen, Sandra

“…To assess the response to pexidartinib treatment in six cohorts of adult patients with advanced, incurable solid tumors associated with colony-stimulating…”
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Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia by Smith, Catherine C, Viny, Aaron D, Massi, Evan, Kandoth, Cyriac, Socci, Nicholas D, Rapaport, Franck, Najm, Matthieu, Medina-Martinez, Juan S, Papaemmanuil, Elli, Tarver, Theodore C, Hsu, Henry H, Le, Mai H, West, Brian, Bollag, Gideon, Taylor, Barry S, Levine, Ross L, Shah, Neil P

“…Biomarkers of response and resistance to FLT3 tyrosine kinase inhibitors (TKI) are still emerging, and optimal clinical combinations remain unclear. The…”
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Pilot study of interferon gamma for chronic hepatitis C by Soza, Alejandro, Heller, Theo, Ghany, Marc, Lutchman, Glen, Jake Liang, T., Germain, June, Hsu, Henry H., Park, Yoon, Hoofnagle, Jay H.

“…Currently, there are no effective therapies available for patients with chronic hepatitis C who have failed to respond to optimal interferon alfa-based…”
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Therapeutic Effect of Topical Adiponectin-Derived Short Peptides Compared with Globular Adiponectin in Experimental Dry Eye and Alkali Burn by Li, Ying, Jin, Rujun, Li, Lan, Hsu, Henry H, You, In Cheon, Yoon, Hyeon Jeong, Yoon, Kyung Chul

“…To evaluate the efficacy of adiponectin (APN)-derived short peptides (ADPs) 355 compared with globular APN in a mouse model of experimental dry eye (EDE) and…”
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CSF1 receptor inhibition of tenosynovial giant cell tumor using novel disease-specific MRI measures of tumor burden by Peterfy, Charles, Chen, Yan, Countryman, Peter, Chmielowski, Bartosz, Anthony, Stephen P, Healey, John H, Wainberg, Zev A, Cohn, Allen L, Shapiro, Geoffrey I, Keedy, Vicki L, Singh, Arun, Puzanov, Igor, Wagner, Andrew J, Qian, Meng, Sterba, Mike, Hsu, Henry H, Tong-Starksen, Sandra, Tap, William D

“…Monitoring treatment of tenosynovial giant cell tumor (TGCT) is complicated by the irregular shape and asymmetrical growth of the tumor. We compared responses…”
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Phase Ⅰ/Ⅱ, Double-Masked, Randomized, Vehicle-Controlled Study of H-1337 Ophthalmic Solution for Glaucoma and Ocular Hypertension by Hartman, Paul J, Cooke, David L, Hsu, Henry H, Stewart, Jeanette, Sumi, Kengo, Yoshida, Yoko, Hidaka, Hiroyoshi, Novack, Gary D

“…To perform a phase Ⅰ/Ⅱ evaluation of an H-1337 ophthalmic solution in subjects with primary open-angle glaucoma (POAG) or ocular hypertension (OHT). This was a…”
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