Search Results - "Hsu, Ethan"
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Pulsed radiotherapy to mitigate high tumor burden and generate immune memory
Published in Frontiers in immunology (06-10-2022)“…Radiation therapy (XRT) has a well-established role in cancer treatment. Given the encouraging results on immunostimulatory effects, radiation has been…”
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Pulsed Radiation Therapy to Improve Systemic Control of Metastatic Cancer
Published in Frontiers in oncology (23-08-2021)“…Radiation therapy (RT) is emerging as an interventional modality in the cancer-immunity cycle, augmenting the activation of an adaptive immune response against…”
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Novel Use of Low-Dose Radiotherapy to Modulate the Tumor Microenvironment of Liver Metastases
Published in Frontiers in immunology (15-12-2021)“…Despite multiple therapeutic approaches, the presence of liver metastases carries a guarded prognosis, urgently necessitating further clinical and scientific…”
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Novel engineered IL-2 Nemvaleukin alfa combined with PD1 checkpoint blockade enhances the systemic anti-tumor responses of radiation therapy
Published in Journal of experimental & clinical cancer research (02-09-2024)“…Combining interleukin-2 (IL-2) with radiotherapy (RT) and immune checkpoint blockade (ICB) has emerged as a promising approach to address ICB resistance…”
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Bone morphogenetic proteins, activins, and growth and differentiation factors in tumor immunology and immunotherapy resistance
Published in Frontiers in immunology (24-10-2022)“…The TGF-β superfamily is a group of secreted polypeptides with key roles in exerting and regulating a variety of physiologic effects, especially those related…”
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NBTXR3 improves the efficacy of immunoradiotherapy combining nonfucosylated anti-CTLA4 in an anti-PD1 resistant lung cancer model
Published in Frontiers in immunology (03-11-2022)“…The efficacy of immunoradiotherapy consisting of radiation therapy and immune checkpoint blockade relies on effectively promoting the systemic antitumor immune…”
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The RadScopal Technique as an Immune Adjuvant to Treat Cancer
Published in Immuno (01-03-2023)“…Since the momentous discovery of X-rays, high-dose radiotherapy (H-XRT) has been a cornerstone for combating cancer. The high-energy electromagnetic waves…”
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Enhanced tumor control and survival in preclinical models with adoptive cell therapy preceded by low-dose radiotherapy
Published in Frontiers in oncology (09-10-2024)“…Effective infiltration of chimeric antigen receptor T (CAR-T) cells into solid tumors is critical for achieving a robust antitumor response and improving…”
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Nanoparticle-enhanced proton beam immunoradiotherapy drives immune activation and durable tumor rejection
Published in JCI insight (22-06-2023)“…The combination of radiation therapy (RT) and immunotherapy has emerged as a promising treatment option in oncology. Historically, x-ray radiation (XRT) has…”
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Radiation Therapy Modulates Tumor Physical Characteristics to Reduce Intratumoral Pressure and Enhance Intratumoral Drug Delivery and Retention
Published in Advances in radiation oncology (01-03-2023)“…High intratumoral pressure, caused by tumor cell-to-cell interactions, interstitial fluid pressure, and surrounding stromal composition, plays a substantial…”
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Systemic AAV9.BVES delivery ameliorates muscular dystrophy in a mouse model of LGMDR25
Published in Molecular therapy (01-02-2023)“…Limb-girdle muscular dystrophy type R25 (LGMDR25) is caused by recessive mutations in BVES encoding a cAMP-binding protein, characterized by progressive…”
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NLRP3 agonist enhances radiation-induced immune priming and promotes abscopal responses in anti-PD1 resistant model
Published in Cancer Immunology, Immunotherapy (01-09-2023)“…Radiotherapy (XRT), a well-known activator of the inflammasome and immune priming, is in part capable of reversing resistance to anti-PD1 treatment. The NLRP3…”
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High Plus Low Dose Radiation Strategy in Combination with TIGIT and PD1 Blockade to Promote Systemic Antitumor Responses
Published in Cancers (03-01-2022)“…Tumors deploy various immune-evasion mechanisms that create a suppressive environment and render effector T-cells exhausted and inactive. Therefore, a rational…”
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869 NBTXR3-enhanced proton beam immunoradiotherapy reshapes tumor immune microenvironment and improves abscopal effect in an anti-PD1-resistant lung cancer
Published in Journal for immunotherapy of cancer (01-11-2022)“…BackgroundProton beam therapy (PBT) has frequently yielded superior results to conventional X-ray therapy. However, combination of PBT with checkpoint…”
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Electrostatics and ballistic transport studies in junctionless nanowire transistors
Published in 2013 International Conference on Simulation of Semiconductor Processes and Devices (SISPAD) (01-09-2013)“…In this work a drift-diffusion simulator is utilized to study the electrostatics of a cylindrical gate-all-around junctionless nanowire transistor. For carrier…”
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