Search Results - "Hsieh, Elena W. Y."

Highly multiplexed simultaneous detection of RNAs and proteins in single cells by Frei, Andreas P, Bava, Felice-Alessio, Zunder, Eli R, Hsieh, Elena W Y, Chen, Shih-Yu, Nolan, Garry P, Gherardini, Pier Federico

“…PLAYR (proximity ligation assay for RNA) enables highly multiplexed transcript quantification in combination with protein marker detection in single cells…”
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Congenital Athymia: Genetic Etiologies, Clinical Manifestations, Diagnosis, and Treatment by Collins, Cathleen, Sharpe, Emily, Silber, Abigail, Kulke, Sarah, Hsieh, Elena W. Y.

“…Congenital athymia is an ultra-rare disease characterized by the absence of a functioning thymus. It is associated with several genetic and syndromic disorders…”
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A platform-independent framework for phenotyping of multiplex tissue imaging data by Ahmadian, Mansooreh, Rickert, Christian, Minic, Angela, Wrobel, Julia, Bitler, Benjamin G, Xing, Fuyong, Angelo, Michael, Hsieh, Elena W Y, Ghosh, Debashis, Jordan, Kimberly R

“…Multiplex imaging is a powerful tool to analyze the structural and functional states of cells in their morphological and pathological contexts. However,…”
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Specialized interferon action in COVID-19 by Galbraith, Matthew D, Kinning, Kohl T, Sullivan, Kelly D, Araya, Paula, Smith, Keith P, Granrath, Ross E, Shaw, Jessica R, Baxter, Ryan, Jordan, Kimberly R, Russell, Seth, Dzieciatkowska, Monika, Reisz, Julie A, Gamboni, Fabia, Cendali, Francesca, Ghosh, Tusharkanti, Guo, Kejun, Wilson, Cara C, Santiago, Mario L, Monte, Andrew A, Bennett, Tellen D, Hansen, Kirk C, Hsieh, Elena W Y, D'Alessandro, Angelo, Espinosa, Joaquin M

“…The impacts of interferon (IFN) signaling on COVID-19 pathology are multiple, with both protective and harmful effects being documented. We report here a…”
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Minimizing Batch Effects in Mass Cytometry Data by Schuyler, Ronald P, Jackson, Conner, Garcia-Perez, Josselyn E, Baxter, Ryan M, Ogolla, Sidney, Rochford, Rosemary, Ghosh, Debashis, Rudra, Pratyaydipta, Hsieh, Elena W Y

“…Cytometry by Time-Of-Flight (CyTOF) uses antibodies conjugated to isotopically pure metals to identify and quantify a large number of cellular features with…”
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Dysregulated Lymphocyte Antigen Receptor Signaling in Common Variable Immunodeficiency with Granulomatous Lymphocytic Interstitial Lung Disease by Lui, Victor G., Ghosh, Tusharkanti, Rymaszewski, Amy, Chen, Shaoying, Baxter, Ryan M., Kong, Daniel S., Ghosh, Debashis, Routes, John M., Verbsky, James W., Hsieh, Elena W. Y.

“…Purpose A subset of common variable immunodeficiency (CVID) patients either presents with or develops autoimmune and lymphoproliferative complications, such as…”
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Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus by Baxter, Ryan M, Wang, Christine S, Garcia-Perez, Josselyn E, Kong, Daniel S, Coleman, Brianne M, Larchenko, Valentyna, Schuyler, Ronald P, Jackson, Conner, Ghosh, Tusharkanti, Rudra, Pratyaydipta, Paul, Debdas, Claassen, Manfred, Rochford, Rosemary, Cambier, John C, Ghosh, Debashis, Cooper, Jennifer C, Smith, Mia J, Hsieh, Elena W Y

“…Most childhood-onset SLE patients (cSLE) develop lupus nephritis (cLN), but only a small proportion achieve complete response to current therapies. The…”
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Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus by O'Gorman, William E., PhD, Hsieh, Elena W.Y., MD, Savig, Erica S., BA, Gherardini, Pier Federico, PhD, Hernandez, Joseph D., MD, PhD, Hansmann, Leo, PhD, Balboni, Imelda M., MD, PhD, Utz, Paul J., MD, PhD, Bendall, Sean C., PhD, Fantl, Wendy J., PhD, Lewis, David B., MD, Nolan, Garry P., PhD, Davis, Mark M., PhD

“…Background Activation of Toll-like receptors (TLRs) induces inflammatory responses involved in immunity to pathogens and autoimmune pathogenesis, such as in…”
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Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition by Galbraith, Matthew D, Rachubinski, Angela L, Smith, Keith P, Araya, Paula, Waugh, Katherine A, Enriquez-Estrada, Belinda, Worek, Kayleigh, Granrath, Ross E, Kinning, Kohl T, Paul Eduthan, Neetha, Ludwig, Michael P, Hsieh, Elena W Y, Sullivan, Kelly D, Espinosa, Joaquin M

“…Individuals with Down syndrome (DS) display chronic hyperactivation of interferon signaling. However, the clinical impacts of interferon hyperactivity in DS…”
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CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade by Garcia-Perez, Josselyn E, Baxter, Ryan M, Kong, Daniel S, Tobin, Richard, McCarter, Martin, Routes, John M, Verbsky, James, Jordan, Michael B, Dutmer, Cullen M, Hsieh, Elena W Y

“…CTLA-4 is essential for immune tolerance. Heterozygous mutations cause immune dysregulation evident in defective regulatory T cells with low levels of CTLA-4…”
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Novel tools for primary immunodeficiency diagnosis: making a case for deep profiling by Hsieh, Elena W.Y, Hernandez, Joseph D

“…PURPOSE OF REVIEWThis review gives an overview of the systems-immunology single-cell proteomic and transcriptomic approaches that can be applied to study…”
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A Phased Approach to Resuming Suspended Allergy/Immunology Clinical Services by Searing, Daniel A., Dutmer, Cullen M., Fleischer, David M., Shaker, Marcus S., Oppenheimer, John, Grayson, Mitchell H., Stukus, David, Hartog, Nicholas, Hsieh, Elena W.Y., Rider, Nicholas L., Vander Leek, Timothy K., Kim, Harold, Chan, Edmond S., Mack, Doug, Ellis, Anne K., Abrams, Elissa M., Bansal, Priya, Lang, David M., Lieberman, Jay, Golden, David BK, Wallace, Dana, Portnoy, Jay, Mosnaim, Giselle, Greenhawt, Matthew

“…In early 2020, the first US and Canadian cases of the novel severe acute respiratory syndrome coronavirus 2 infection were detected. In the ensuing months,…”
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Cyt‐Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2019 Conference Workshops by Czechowska, Kamila, Lannigan, Joanne, Aghaeepour, Nima, Back, Jessica B., Begum, Julfa, Behbehani, Greg, Bispo, Cláudia, Bitoun, Daniel, Fernández, Alfonso Blanco, Boova, Samuel Tony, Brinkman, Ryan Remy, Ciccolella, Christopher O., Cotleur, Bunny, Davies, Derek, Dela Cruz, Gelo Victoriano, Del Rio‐Guerra, Roxana, Des Lauriers‐Cox, Ann Marie, Douagi, Iyadh, Dumrese, Claudia, Bonilla Escobar, Diana L., Estevam, Jose, Ewald, Christina, Fossum, Anna, Gaudillière, Brice, Green, Cherie, Groves, Christopher, Hall, Christopher, Haque, Yasmin, Hedrick, Michael Nathan, Hogg, Karen, Hsieh, Elena W.Y., Irish, Jonathan, Lederer, James, Leipold, Michael, Lewis‐Tuffin, Laura J., Litwin, Virginia, Lopez, Peter, Nasdala, Ines, Nedbal, Jakub, Ohlsson‐Wilhelm, Betsy M., Price, Kylie M., Rahman, Adeeb H., Rayanki, Radhika, Rieger, Aja M., Robinson, J. Paul, Shapiro, Howard, Sun, Yongliang Steve, Tang, Vera A., Tesfa, Lydia, Telford, William G., Walker, Rachael, Welsh, Joshua A., Wheeler, Paul, Tárnok, Attila

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Inborn errors of immunity illuminate mechanisms of human immunology and pave the road to precision medicine by Hsieh, Elena W. Y., Bolze, Alexandre, Hernandez, Joseph D.

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Reply to “Subcutaneous terbutaline as an alternative to aerosolized albuterol” by Shaker, Marcus S., Oppenheimer, John, Grayson, Mitchell, Stukus, David, Hartog, Nicholas, Hsieh, Elena W.Y., Rider, Nicholas, Dutmer, Cullen M., Vander Leek, Timothy K., Kim, Harold, Chan, Edmond S., Mack, Doug, Ellis, Anne K., Lang, David, Lieberman, Jay, Fleischer, David, Golden, David B.K., Wallace, Dana, Portnoy, Jay, Mosnaim, Giselle, Greenhawt, Matthew

“…To the Editor: We appreciate the comments and perspective expressed by Dr. Strauss regarding our recent pandemic contingency guidance,1 and we agree that in…”
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COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic by Shaker, Marcus S., Oppenheimer, John, Grayson, Mitchell, Stukus, David, Hartog, Nicholas, Hsieh, Elena W.Y., Rider, Nicholas, Dutmer, Cullen M., Vander Leek, Timothy K., Kim, Harold, Chan, Edmond S., Mack, Doug, Ellis, Anne K., Lang, David, Lieberman, Jay, Fleischer, David, Golden, David B.K., Wallace, Dana, Portnoy, Jay, Mosnaim, Giselle, Greenhawt, Matthew

“…In the event of a global infectious pandemic, drastic measures may be needed that limit or require adjustment of ambulatory allergy services. However, no…”
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A great disturbance in the force: IL-2 receptor defects disrupt immune homeostasis by Hernandez, Joseph D., Hsieh, Elena W.Y.

“…The current review highlights how inborn errors of immunity (IEI) due to IL-2 receptor (IL-2R) subunit defects may result in children presenting with a wide…”
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A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation by Fernandez, Isabel Z, Baxter, Ryan M, Garcia-Perez, Josselyn E, Vendrame, Elena, Ranganath, Thanmayi, Kong, Daniel S, Lundquist, Karl, Nguyen, Tom, Ogolla, Sidney, Black, Jennifer, Galambos, Csaba, Gumbart, James C, Dawany, Noor, Kelsen, Judith R, de Zoeten, Edwin F, Quinones, Ralph, Eissa, Hesham, Verneris, Michael R, Sullivan, Kathleen E, Rochford, Rosemary, Blish, Catherine A, Kedl, Ross M, Dutmer, Cullen M, Hsieh, Elena W Y

“…The pleiotropic actions of interleukin-2 (IL-2) are essential for regulation of immune responses and maintenance of immune tolerance. The IL-2 receptor (IL-2R)…”
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T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients by Kuehn, Hye Sun, Chang, Jingjie, Yamashita, Motoi, Niemela, Julie E, Zou, Chengcheng, Okuyama, Kazuki, Harada, Junji, Stoddard, Jennifer L, Nunes-Santos, Cristiane J, Boast, Brigette, Baxter, Ryan M, Hsieh, Elena W Y, Garofalo, Mary, Fleisher, Thomas A, Morio, Tomohiro, Taniuchi, Ichiro, Dutmer, Cullen M, Rosenzweig, Sergio D

“…AIOLOS/IKZF3 is a member of the IKAROS family of transcription factors. IKAROS/IKZF1 mutations have been previously associated with different forms of primary…”
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Hypogammaglobulinemia after rituximab therapy in children by Newman, Erik N., Israelsen, Ryan B., Williamson, Kayla, Hsieh, Elena W.Y.

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