Search Results - "Hsieh, Edward J."

Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart by Dai, Dao‐Fu, Karunadharma, Pabalu P., Chiao, Ying A., Basisty, Nathan, Crispin, David, Hsieh, Edward J., Chen, Tony, Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Beyer, Richard P., MacCoss, Michael J., Rabinovitch, Peter S.

“…Summary Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin (mTOR) signaling, thereby regulating metabolism and…”
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Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides by Dai, Dao-Fu, Hsieh, Edward J, Chen, Tony, Menendez, Lorena G, Basisty, Nathan B, Tsai, Lauren, Beyer, Richard P, Crispin, David A, Shulman, Nicholas J, Szeto, Hazel H, Tian, Rong, MacCoss, Michael J, Rabinovitch, Peter S

“…We investigated the protective effects of mitochondrial-targeted antioxidant and protective peptides, Szeto-Schiller (SS) 31 and SS20, on cardiac function,…”
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Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants by Xie, Letian X., Hsieh, Edward J., Watanabe, Shota, Allan, Christopher M., Chen, Jia Y., Tran, UyenPhuong C., Clarke, Catherine F.

“…Coenzyme Q (ubiquinone or Q) is a lipid electron and proton carrier in the electron transport chain. In yeast Saccharomyces cerevisiae eleven genes, designated…”
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Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies by Dang, Xibei, Guelen, Lars, Lutje Hulsik, David, Ermakov, Grigori, Hsieh, Edward J, Kreijtz, Joost, Stammen-Vogelzangs, Judith, Lodewijks, Imke, Bertens, Astrid, Bramer, Arne, Guadagnoli, Marco, Nazabal, Alexis, van Elsas, Andrea, Fischmann, Thierry, Juan, Veronica, Beebe, Amy, Beaumont, Maribel, van Eenennaam, Hans

“…Monoclonal antibodies have become an important class of therapeutics in the last 30 years. Because the mechanism of action of therapeutic antibodies is…”
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Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase by Marsillach, Judit, Suzuki, Stephanie M, Richter, Rebecca J, McDonald, Matthew G, Rademacher, Peter M, MacCoss, Michael J, Hsieh, Edward J, Rettie, Allan E, Furlong, Clement E

“…Homocysteinylation of lysine residues by homocysteine thiolactone (HCTL), a reactive homocysteine metabolite, results in protein aggregation and malfunction,…”
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Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex by Hsieh, Edward J., Gin, Peter, Gulmezian, Melissa, Tran, UyenPhuong C., Saiki, Ryoichi, Marbois, Beth N., Clarke, Catherine F.

“…Coenzyme Q (Q) is a redox active lipid that is an essential component of the electron transport chain. Here, we show that steady state levels of Coq3, Coq4,…”
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Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures by Marsillach, Judit, Hsieh, Edward J., Richter, Rebecca J., MacCoss, Michael J., Furlong, Clement E.

“…Organophosphorus (OP) compounds include a broad group of toxic chemicals such as insecticides, chemical warfare agents and antiwear agents. The liver…”
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COQ9, a New Gene Required for the Biosynthesis of Coenzyme Q in Saccharomyces cerevisiae by Johnson, Alisha, Gin, Peter, Marbois, Beth N., Hsieh, Edward J., Wu, Mian, Barros, Mario H., Clarke, Catherine F., Tzagoloff, Alexander

“…Currently, eight genes are known to be involved in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae. Here, we report a new gene designated COQ9 that is…”
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Comparison of Database Search Strategies for High Precursor Mass Accuracy MS/MS Data by Hsieh, Edward J, Hoopmann, Michael R, MacLean, Brendan, MacCoss, Michael J

“…In shotgun proteomics, the analysis of tandem mass spectrometry data from peptides can benefit greatly from high mass accuracy measurements. In this study, we…”
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Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress by Dai, Dao-Fu, Hsieh, Edward J., Liu, Yonggang, Chen, Tony, Beyer, Richard P., Chin, Michael T., MacCoss, Michael J., Rabinovitch, Peter S.

“…Aims We investigate the role of mitochondrial oxidative stress in mitochondrial proteome remodelling using mouse models of heart failure induced by pressure…”
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Effects of Column and Gradient Lengths on Peak Capacity and Peptide Identification in Nanoflow LC-MS/MS of Complex Proteomic Samples by Hsieh, Edward J., Bereman, Michael S., Durand, Stanley, Valaskovic, Gary A., MacCoss, Michael J.

“…Reversed-phase liquid chromatography is the most commonly used separation method for shotgun proteomics. Nanoflow chromatography has emerged as the preferred…”
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Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects by Karunadharma, Pabalu P., Basisty, Nathan, Dai, Dao‐Fu, Chiao, Ying A., Quarles, Ellen K., Hsieh, Edward J., Crispin, David, Bielas, Jason H., Ericson, Nolan G., Beyer, Richard P., MacKay, Vivian L., MacCoss, Michael J., Rabinovitch, Peter S.

“…Summary Calorie restriction (CR) and rapamycin (RP) extend lifespan and improve health across model organisms. Both treatments inhibit mammalian target of…”
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Molecular mechanisms underlying genotype‐dependent responses to dietary restriction by Schleit, Jennifer, Johnson, Simon C., Bennett, Christopher F., Simko, Marissa, Trongtham, Natalie, Castanza, Anthony, Hsieh, Edward J., Moller, Richard M., Wasko, Brian M., Delaney, Joe R., Sutphin, George L., Carr, Daniel, Murakami, Christopher J., Tocchi, Autumn, Xian, Bo, Chen, Weiyang, Yu, Tao, Goswami, Sarani, Higgins, Sean, Holmberg, Mollie, Jeong, Ki‐Soo, Kim, Jin R., Klum, Shannon, Liao, Eric, Lin, Michael S., Lo, Winston, Miller, Hillary, Olsen, Brady, Peng, Zhao J., Pollard, Tom, Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Ros, Vanessa, Singh, Minnie, Spector, Benjamin L., Wende, Helen Vander, An, Elroy H., Fletcher, Marissa, Jelic, Monika, Rabinovitch, Peter S., MacCoss, Michael J., Han, Jing‐Dong J., Kennedy, Brian K., Kaeberlein, Matt

“…Summary Dietary restriction (DR) increases lifespan and attenuates age‐related phenotypes in many organisms; however, the effect of DR on longevity of…”
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Mitochondrial‐targeted catalase is good for the old mouse proteome, but not for the young: ‘reverse’ antagonistic pleiotropy? by Basisty, Nathan, Dai, Dao‐Fu, Gagnidze, Arni, Gitari, Lemuel, Fredrickson, Jeanne, Maina, Yvonne, Beyer, Richard P., Emond, Mary J., Hsieh, Edward J., MacCoss, Michael J., Martin, George M., Rabinovitch, Peter S.

“…Summary Reactive oxygen species (ROS) are highly reactive oxygen‐containing molecules associated with aging and a broad spectrum of pathologies. We have…”
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Topograph, a Software Platform for Precursor Enrichment Corrected Global Protein Turnover Measurements by Hsieh, Edward J., Shulman, Nicholas J., Dai, Dao-Fu, Vincow, Evelyn S., Karunadharma, Pabalu P., Pallanck, Leo, Rabinovitch, Peter S., MacCoss, Michael J.

“…Defects in protein turnover have been implicated in a broad range of diseases, but current proteomics methods of measuring protein turnover are limited by the…”
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Development and Characterization of a Novel Plug and Play Liquid Chromatography-Mass Spectrometry (LC-MS) Source That Automates Connections between the Capillary Trap, Column, and Emitter by Bereman, Michael S., Hsieh, Edward J., Corso, Thomas N., Van Pelt, Colleen K., MacCoss, Michael J.

“…We report the development and characterization of a novel, vendor-neutral ultra-high pressure-compatible (∼10,000 p.s.i.) LC-MS source. This device is the…”
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De Novo Correction of Mass Measurement Error in Low Resolution Tandem MS Spectra for Shotgun Proteomics by Egertson, Jarrett D., Eng, Jimmy K., Bereman, Michael S., Hsieh, Edward J., Merrihew, Gennifer E., MacCoss, Michael J.

“…We report an algorithm designed for the calibration of low resolution peptide mass spectra. Our algorithm is implemented in a program called FineTune, which…”
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A tRNA(TRP) gene mediates the suppression of cbs2-223 previously attributed to ABC1/COQ8 by Hsieh, Edward J, Dinoso, Jason B, Clarke, Catherine F

“…The Saccharomyces cerevisiae gene ABC1 was originally isolated as a multicopy suppressor of a yeast strain harboring a mutation in a cytochrome b translational…”
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Expression of Human ADCK3 restores Coenzyme Q biosynthesis and Phosphorylation of Coq polypeptides in yeast abc1/coq8 mutants by Xie, Letian, Hsieh, Edward J., Watanabe, Shota, Allan, Chris M., Tran, UyenPhuong C., Clarke, Catherine F.

“…Coenzyme Q (ubiquinone or Q) is a lipid electron carrier in the electron transport chain. In yeast Saccharomyces cerevisiae nine genes, designated COQ1 through…”
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A tRNATRP gene mediates the suppression of cbs2-223 previously attributed to ABC1/COQ8 by Hsieh, Edward J., Dinoso, Jason B., Clarke, Catherine F.

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