Search Results - "Hsiao, W."
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The role of traditional Chinese herbal medicines in cancer therapy--from TCM theory to mechanistic insights
Published in Planta medica (01-08-2010)“…Traditional Chinese medicine-based herbal medicines have gained increasing acceptance worldwide in recent years and are being pursued by pharmaceutical…”
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Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model
Published in Phytomedicine (Stuttgart) (01-02-2020)“…Inulin-type fructo-oligosaccharides (FOSs) purified from Morinda officinalis How., an effective oral antidepressant for mild to moderate depression, have a…”
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Polarity-Tuning Derivatization-LC-MS Approach for Probing Global Carboxyl-Containing Metabolites in Colorectal Cancer
Published in Analytical chemistry (Washington) (02-10-2018)“…Carboxyl-containing metabolites (CCMs) widely exist in living systems and are the essential components for life. Global characteristics of CCMs in biological…”
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Application of protoplast technology to CRISPR/Cas9 mutagenesis: from single‐cell mutation detection to mutant plant regeneration
Published in Plant biotechnology journal (01-07-2018)“…Summary Plant protoplasts are useful for assessing the efficiency of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated…”
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mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
Published in Nature communications (29-01-2020)“…mTORC2 phosphorylates AKT in a hydrophobic motif site that is a biomarker of insulin sensitivity. In brown adipocytes, mTORC2 regulates glucose and lipid…”
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Discovery of the bioactive peptides secreted by Bifidobacterium using integrated MCX coupled with LC–MS and feature-based molecular networking
Published in Food chemistry (15-06-2021)“…•An integrated approach based on MCX-SPE coupled with LC–MS and FBMN was developed.•25 novel bioactive peptides were quickly characterized from…”
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Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure
Published in International journal of pharmaceutics (25-07-2016)“…[Display omitted] We present our recent advancements in developing a viable manufacturing process for printed medicine. Our approach involves using a…”
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Adaptogenic flower buds exert cancer preventive effects by enhancing the SCFA-producers, strengthening the epithelial tight junction complex and immune responses
Published in Pharmacological research (01-09-2020)“…[Display omitted] Microbiome therapy has attracted a keen interest from both research and business sectors. Our lab has been applying this “second genome”…”
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Vorinostat targets UBE2C to reverse epithelial-mesenchymal transition and control cervical cancer growth through the ubiquitination pathway
Published in European journal of pharmacology (05-10-2021)“…Vorinostat is a histone deacetylase inhibitor (HDACi) that was demonstrated in our previous study to inhibit the proliferation, migration, and invasion of…”
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Thermoreversible Pluronic F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake studies
Published in International journal of nanomedicine (01-01-2011)“…To develop an in situ gel system comprising liposome-containing paclitaxel (PTX) dispersed within the thermoreversible gel (Pluronic® F127 gel) for controlled…”
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Icariin enhances youth-like features by attenuating the declined gut microbiota in the aged mice
Published in Pharmacological research (01-06-2021)“…We previously reported the neuroprotective effects of icariin in rat cortical neurons. Here, we present a study on icariin's anti-aging effect in 24-month aged…”
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Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+ mice
Published in Scientific reports (02-10-2017)“…Studies showed that manipulation of gut microbiota (GM) composition through the treatment of prebiotics could be a novel preventive measure against colorectal…”
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Investigation into powder tribo-charging of pharmaceuticals. Part I: Process-induced charge via twin-screw feeding
Published in International journal of pharmaceutics (15-12-2020)“…[Display omitted] Powder feeding is a crucial unit operation in continuous manufacturing (CM) of pharmaceutical products. Twin-screw feeders are typically…”
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OntoTrek: 3D visualization of application ontology class hierarchies
Published in PloS one (02-06-2023)“…An application ontology often reuses terms from other related, compatible ontologies. The extent of this interconnectedness is not readily apparent when…”
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Mushroom polysaccharides from Ganoderma lucidum and Poria cocos reveal prebiotic functions
Published in Journal of functional foods (01-02-2018)“…•Medicinal mushroom polysaccharides on gut microbiota were investigated.•Polysaccharides promoted anti-obesity and anti-inflammatory bacteria.•Polysaccharides…”
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A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis
Published in Diabetes, obesity & metabolism (01-05-2015)“…Aim To investigate the in vivo metabolic effects of treatment with BPR0912, a novel and potent peripheral cannabinoid receptor 1 (CB1R) antagonist, on both…”
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Traditional Patchouli essential oil modulates the host’s immune responses and gut microbiota and exhibits potent anti-cancer effects in ApcMin /+ mice
Published in Pharmacological research (01-02-2022)“…Patchouli Essential Oil (PEO) has been used as a scent for various healing purposes since the ancient Egyptian period. The primary source of the oil is…”
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Tumor grafting induces changes of gut microbiota in athymic nude mice in the presence and absence of medicinal Gynostemma saponins
Published in PloS one (20-05-2015)“…Recent findings have revealed that gut microbiota plays a substantial role in modulating diseases such as autism, rheumatoid arthritis, allergies, and cancer…”
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Analyzing Endodontic Infections by Deep Coverage Pyrosequencing
Published in Journal of dental research (01-09-2010)“…Bacterial diversity in endodontic infections has not been sufficiently studied. The use of modern pyrosequencing technology should allow for more comprehensive…”
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