Search Results - "Hsiao, Elaine Y."

Signaling inflammation across the gut-brain axis by Agirman, Gulistan, Yu, Kristie B, Hsiao, Elaine Y

“…The brain and gastrointestinal tract are critical sensory organs responsible for detecting, relaying, integrating, and responding to signals derived from the…”
Get full text

Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder by Vuong, Helen E, Hsiao, Elaine Y

“…Abstract Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that affects one in 45 children in the United States, with a similarly…”
Get full text

Perinatal Interactions between the Microbiome, Immunity, and Neurodevelopment by Pronovost, Geoffrey N., Hsiao, Elaine Y.

“…The microbiome modulates host immune function across the gastrointestinal tract, peripheral lymphoid organs, and central nervous system. In this review, we…”
Get full text

The Microbiome and Host Behavior by Vuong, Helen E, Yano, Jessica M, Fung, Thomas C, Hsiao, Elaine Y

“…The microbiota is increasingly recognized for its ability to influence the development and function of the nervous system and several complex host behaviors…”
Get full text

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis by Yano, Jessica M., Yu, Kristie, Donaldson, Gregory P., Shastri, Gauri G., Ann, Phoebe, Ma, Liang, Nagler, Cathryn R., Ismagilov, Rustem F., Mazmanian, Sarkis K., Hsiao, Elaine Y.

“…The gastrointestinal (GI) tract contains much of the body’s serotonin (5-hydroxytryptamine, 5-HT), but mechanisms controlling the metabolism of gut-derived…”
Get full text

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet by Olson, Christine A., Vuong, Helen E., Yano, Jessica M., Liang, Qingxing Y., Nusbaum, David J., Hsiao, Elaine Y.

“…The ketogenic diet (KD) is used to treat refractory epilepsy, but the mechanisms underlying its neuroprotective effects remain unclear. Here, we show that the…”
Get full text

Emerging roles for the intestinal microbiome in epilepsy by Lum, Gregory R., Olson, Christine A., Hsiao, Elaine Y.

“…The gut microbiome is emerging as a key regulator of brain function and behavior and is associated with symptoms of several neurological disorders. There is…”
Get full text

Activation of the maternal immune system induces endocrine changes in the placenta via IL-6 by Hsiao, Elaine Y, Patterson, Paul H

“…Abstract Activation of the maternal immune system in rodent models sets in motion a cascade of molecular pathways that ultimately result in autism- and…”
Get full text

The maternal microbiome modulates fetal neurodevelopment in mice by Vuong, Helen E., Pronovost, Geoffrey N., Williams, Drake W., Coley, Elena J. L., Siegler, Emily L., Qiu, Austin, Kazantsev, Maria, Wilson, Chantel J., Rendon, Tomiko, Hsiao, Elaine Y.

“…‘Dysbiosis’ of the maternal gut microbiome, in response to challenges such as infection 1 , altered diet 2 and stress 3 during pregnancy, has been increasingly…”
Get full text

The placental interleukin-6 signaling controls fetal brain development and behavior by Wu, Wei-Li, Hsiao, Elaine Y, Yan, Zihao, Mazmanian, Sarkis K, Patterson, Paul H

“…Highlights • IL-6 downstream signaling is activated in specific regions of fetal hindbrain after MIA. • Placental IL-6Rα knockout prevents MIA induced…”
Get full text

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders by Hsiao, Elaine Y., McBride, Sara W., Hsien, Sophia, Sharon, Gil, Hyde, Embriette R., McCue, Tyler, Codelli, Julian A., Chow, Janet, Reisman, Sarah E., Petrosino, Joseph F., Patterson, Paul H., Mazmanian, Sarkis K.

“…Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core behavioral impairments; however, subsets of individuals display a…”
Get full text

Gut microbiota Turicibacter strains differentially modify bile acids and host lipids by Lynch, Jonathan B., Gonzalez, Erika L., Choy, Kayli, Faull, Kym F., Jewell, Talia, Arellano, Abelardo, Liang, Jennifer, Yu, Kristie B., Paramo, Jorge, Hsiao, Elaine Y.

“…Bacteria from the Turicibacter genus are prominent members of the mammalian gut microbiota and correlate with alterations in dietary fat and body weight, but…”
Get full text

Placental regulation of maternal‐fetal interactions and brain development by Hsiao, Elaine Y., Patterson, Paul H.

“…A variety prenatal insults are associated with the incidence of neurodevelopmental disorders such as schizophrenia, autism and cerebral palsy. While the…”
Get full text

Modeling an autism risk factor in mice leads to permanent immune dysregulation by Hsiao, Elaine Y, McBride, Sara W, Chow, Janet, Mazmanian, Sarkis K, Patterson, Paul H

“…Increasing evidence highlights a role for the immune system in the pathogenesis of autism spectrum disorder (ASD), as immune dysregulation is observed in the…”
Get full text

Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model by Kentner, Amanda C, Bilbo, Staci D, Brown, Alan S, Hsiao, Elaine Y, McAllister, A Kimberley, Meyer, Urs, Pearce, Brad D, Pletnikov, Mikhail V, Yolken, Robert H, Bauman, Melissa D

“…The 2017 American College of Neuropychopharmacology (ACNP) conference hosted a Study Group on 4 December 2017, Establishing best practice guidelines to improve…”
Get full text

Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism by Malkova, Natalia V, Yu, Collin Z, Hsiao, Elaine Y, Moore, Marlyn J, Patterson, Paul H

“…Highlight ► We find that activation of the maternal immune system yields offspring with cardinal symptoms of autism: highly repetitive behavior and deficits in…”
Get full text

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet by Olson, Christine A., Vuong, Helen E., Yano, Jessica M., Liang, Qingxing Y., Nusbaum, David J., Hsiao, Elaine Y.

Get full text

Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development by Garay, Paula A, Hsiao, Elaine Y, Patterson, Paul H, McAllister, A.K

“…Highlight ► Maternal immune activation leads to chronic, region-specific changes in brain and serum cytokines in offspring throughout development, as in autism…”
Get full text

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut by Fung, Thomas C., Vuong, Helen E., Luna, Cristopher D. G., Pronovost, Geoffrey N., Aleksandrova, Antoniya A., Riley, Noah G., Vavilina, Anastasia, McGinn, Julianne, Rendon, Tomiko, Forrest, Lucy R., Hsiao, Elaine Y.

“…The gut microbiota regulates levels of serotonin (5-hydroxytryptamine (5-HT)) in the intestinal epithelium and lumen 1 – 5 . However, whether 5-HT plays a…”
Get full text

Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects by Osadchiy, Vadim, Labus, Jennifer S, Gupta, Arpana, Jacobs, Jonathan, Ashe-McNalley, Cody, Hsiao, Elaine Y, Mayer, Emeran A

“…A growing body of preclinical and clinical literature suggests that brain-gut-microbiota interactions play an important role in human health and disease,…”
Get full text