Search Results - "Hsia, Yang"

Parameter Selection for Linear Support Vector Regression by Hsia, Jui-Yang, Lin, Chih-Jen

“…In linear support vector regression (SVR), the regularization and error sensitivity parameters are used to avoid overfitting the training data. A proper…”
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Designed proteins induce the formation of nanocage-containing extracellular vesicles by Votteler, Jörg, Ogohara, Cassandra, Yi, Sue, Hsia, Yang, Nattermann, Una, Belnap, David M., King, Neil P., Sundquist, Wesley I.

“…Autonomously produced hybrid biological nanomaterials termed ‘enveloped protein nanocages’ incorporate features for membrane binding, self-assembly, and ESCRT…”
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Reconfigurable asymmetric protein assemblies through implicit negative design by Sahtoe, Danny D, Praetorius, Florian, Courbet, Alexis, Hsia, Yang, Wicky, Basile I M, Edman, Natasha I, Miller, Lauren M, Timmermans, Bart J R, Decarreau, Justin, Morris, Hana M, Kang, Alex, Bera, Asim K, Baker, David

“…Asymmetric multiprotein complexes that undergo subunit exchange play central roles in biology but present a challenge for design because the components must…”
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Design of multi-scale protein complexes by hierarchical building block fusion by Hsia, Yang, Mout, Rubul, Sheffler, William, Edman, Natasha I., Vulovic, Ivan, Park, Young-Jun, Redler, Rachel L., Bick, Matthew J., Bera, Asim K., Courbet, Alexis, Kang, Alex, Brunette, T. J., Nattermann, Una, Tsai, Evelyn, Saleem, Ayesha, Chow, Cameron M., Ekiert, Damian, Bhabha, Gira, Veesler, David, Baker, David

“…A systematic and robust approach to generating complex protein nanomaterials would have broad utility. We develop a hierarchical approach to designing…”
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Temperature and Different Organs Create Volatile Profile Differences of Edible Gynura [Gynura bicolor (Roxb. ex Willd.) DC] by Ho, Chia-Hsun, Yang, Man-Hsia, Lin, Huey-Ling

“…The volatile profile of the edible vegetable Gynura bicolo r [ Gynura bicolor (Roxb. ex Willd.) DC] was analyzed using gas chromatography-mass spectrometry…”
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Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock by Sheffler, William, Yang, Erin C, Dowling, Quinton, Hsia, Yang, Fries, Chelsea N, Stanislaw, Jenna, Langowski, Mark D, Brandys, Marisa, Li, Zhe, Skotheim, Rebecca, Borst, Andrew J, Khmelinskaia, Alena, King, Neil P, Baker, David

“…Computationally designed multi-subunit assemblies have shown considerable promise for a variety of applications, including a new generation of potent vaccines…”
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A statistical framework for QTL hotspot detection by Wu, Po-Ya, Yang, Man-Hsia, Kao, Chen-Hung

“…Quantitative trait loci (QTL) hotspots (genomic locations enriched in QTL) are a common and notable feature when collecting many QTL for various traits in many…”
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Complex Coacervation of Soy Proteins, Isoflavones and Chitosan by Hsiao, Yu-Hsuan, Hsia, Sheng-Yang, Chan, Yin-Ching, Hsieh, Jung-Feng

“…In this study, the chitosan-induced coacervation of soy protein-isoflavone complexes in soymilk was investigated. Most of the soymilk proteins, including…”
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Dragline Silk: A Fiber Assembled with Low-Molecular-Weight Cysteine-Rich Proteins by Pham, Thanh, Chuang, Tyler, Lin, Albert, Joo, Hyun, Tsai, Jerry, Crawford, Taylor, Zhao, Liang, Williams, Caroline, Hsia, Yang, Vierra, Craig

“…Dragline silk has been proposed to contain two main protein constituents, MaSp1 and MaSp2. However, the mechanical properties of synthetic spider silks spun…”
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A Statistical Procedure for Genome-Wide Detection of QTL Hotspots Using Public Databases with Application to Rice by Yang, Man-Hsia, Wu, Dong-Hong, Kao, Chen-Hung

“…Genome-wide detection of quantitative trait loci (QTL) hotspots underlying variation in many molecular and phenotypic traits has been a key step in various…”
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Conserved C-Terminal Domain of Spider Tubuliform Spidroin 1 Contributes to Extensibility in Synthetic Fibers by Gnesa, Eric, Hsia, Yang, Yarger, Jeffery L, Weber, Warner, Lin-Cereghino, Joan, Lin-Cereghino, Geoff, Tang, Simon, Agari, Kimiko, Vierra, Craig

“…Spider silk is renowned for its extraordinary mechanical properties, having a balance of high tensile strength and extensibility. To date, the majority of…”
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A Rapid SNAP-Tag Fluorogenic Probe Based on an Environment-Sensitive Fluorophore for No-Wash Live Cell Imaging by Liu, Tao-Kai, Hsieh, Pei-Ying, Zhuang, Yu-De, Hsia, Chi-Yang, Huang, Chi-Ling, Lai, Hsiu-Ping, Lin, Hung-Sheung, Chen, I-Chia, Hsu, Hsin-Yun, Tan, Kui-Thong

“…One major limitation of labeling proteins with synthetic fluorophores is the high fluorescence background, which necessitates extensive washing steps to remove…”
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Design of a hyperstable 60-subunit protein icosahedron by Hsia, Yang, Bale, Jacob B., Gonen, Shane, Shi, Dan, Sheffler, William, Fong, Kimberly K., Nattermann, Una, Xu, Chunfu, Huang, Po-Ssu, Ravichandran, Rashmi, Yi, Sue, Davis, Trisha N., Gonen, Tamir, King, Neil P., Baker, David

“…The computational design of an extremely stable icosahedral self-assembling protein nanocage is presented; the icosahedron should be useful for applications…”
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Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS by Sahasrabuddhe, Aniruddha, Hsia, Yang, Busch, Florian, Sheffler, William, King, Neil P., Baker, David, Wysocki, Vicki H.

“…Computational protein design provides the tools to expand the diversity of protein complexes beyond those found in nature. Understanding the rules that drive…”
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Computational design of transmembrane pores by Xu, Chunfu, Lu, Peilong, Gamal El-Din, Tamer M., Pei, Xue Y., Johnson, Matthew C., Uyeda, Atsuko, Bick, Matthew J., Xu, Qi, Jiang, Daohua, Bai, Hua, Reggiano, Gabriella, Hsia, Yang, Brunette, T J, Dou, Jiayi, Ma, Dan, Lynch, Eric M., Boyken, Scott E., Huang, Po-Ssu, Stewart, Lance, DiMaio, Frank, Kollman, Justin M., Luisi, Ben F., Matsuura, Tomoaki, Catterall, William A., Baker, David

“…Transmembrane channels and pores have key roles in fundamental biological processes 1 and in biotechnological applications such as DNA nanopore sequencing 2 –…”
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AutoConjunction: Adaptive Model-based Feature Conjunction for CTR Prediction by Chang, Chih-Yao, Tang, Xing, Yuan, Bo-Wen, Hsia, Jui-Yang, Liu, Zhirong, Dong, Zhenhua, He, Xiuqiang, Lin, Chih-Jen

“…Click-through rate (CTR) prediction is an important topic in mobile recommendation systems and computational advertising. As previous research indicates, a key…”
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Breaking the Symmetry of Protein Assemblies: Structural Flexibility as a De Novo Design Principle by Khmelinskaia, Alena, Borst, Andrew J., Hsia, Yang, Dowling, Quinton, Veesler, David, King, Neil P.

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De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity by Mout, Rubul, Bretherton, Ross C, Decarreau, Justin, Lee, Sangmin, Gregorio, Nicole, Edman, Natasha I, Ahlrichs, Maggie, Hsia, Yang, Sahtoe, Danny D, Ueda, George, Sharma, Alee, Schulman, Rebecca, DeForest, Cole A, Baker, David

“…Relating the macroscopic properties of protein-based materials to their underlying component microstructure is an outstanding challenge. Here, we exploit…”
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De novo design of obligate ABC-type heterotrimeric proteins by Bermeo, Sherry, Favor, Andrew, Chang, Ya-Ting, Norris, Andrew, Boyken, Scott E., Hsia, Yang, Haddox, Hugh K., Xu, Chunfu, Brunette, T. J., Wysocki, Vicki H., Bhabha, Gira, Ekiert, Damian C., Baker, David

“…The de novo design of three protein chains that associate to form a heterotrimer (but not any of the possible two-chain heterodimers) and that can drive the…”
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Accurate computational design of three-dimensional protein crystals by Li, Zhe, Wang, Shunzhi, Nattermann, Una, Bera, Asim K., Borst, Andrew J., Yaman, Muammer Y., Bick, Matthew J., Yang, Erin C., Sheffler, William, Lee, Byeongdu, Seifert, Soenke, Hura, Greg L., Nguyen, Hannah, Kang, Alex, Dalal, Radhika, Lubner, Joshua M., Hsia, Yang, Haddox, Hugh, Courbet, Alexis, Dowling, Quinton, Miranda, Marcos, Favor, Andrew, Etemadi, Ali, Edman, Natasha I., Yang, Wei, Weidle, Connor, Sankaran, Banumathi, Negahdari, Babak, Ross, Michael B., Ginger, David S., Baker, David

“…Protein crystallization plays a central role in structural biology. Despite this, the process of crystallization remains poorly understood and highly…”
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