Search Results - "Hsia, Carleton J.C."

Polynitroxyl-albumin (PNA) enhances myocardial infarction therapeutic effect of tempol in rat hearts subjected to regional ischemia-reperfusion by Li, Haiquan, Ma, Li, Hsia, Carleton J.C, Zweier, Jay L, Kuppusamy, Periannan

“…Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl, TPL), a low molecular weight stable nitroxyl radical (nitroxide), has been demonstrated in many in…”
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Use of Antimetastatic SOD3-Mimetic Albumin as a Primer in Triple Negative Breast Cancer by Miskimins, W. Keith, Hsia, Carleton J. C., Jin, Jenny, Keime, Noah, Soltys, Bohdan J., Zhuang, Yongxian, Schaefer, Amanda M., Messerli, Shanta M., Ma, Li

“…Of the deaths attributed to cancer, 90% are due to metastasis. Treatments that prevent or cure metastasis remain elusive. Low expression of extracellular…”
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Polynitroxylated pegylated hemoglobin: A novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice by Shellington, David K, Du, Lina, Wu, Xianren, Exo, Jennifer, Vagni, Vincent, Ma, Li, Janesko-Feldman, Keri, Clark, Robert S.B, Bayir, Hülya, Dixon, C. Edward, Jenkins, Larry W, Hsia, Carleton J.C, Kochanek, Patrick M

“…OBJECTIVE:Resuscitation of hemorrhagic hypotension after traumatic brain injury is challenging. A hemoglobin-based oxygen carrier may offer advantages. The…”
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Polynitroxyl hemoglobin: a pharmacokinetic study of covalently bound nitroxides to hemoglobin platforms by Buehler, Paul W, Haney, Chad R, Gulati, Anil, Ma, Li, Hsia, Carleton J.C

“…Adding antioxidant activities to hemoglobin-based oxygen carriers (HBOCs) represents a means of reducing cell-free hemoglobin-mediated oxidative cascades. We…”
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Small volume resuscitation with tempol is detrimental during uncontrolled hemorrhagic shock in rats by Kentner, Rainer, Safar, Peter, Behringer, Wilhelm, Wu, Xianren, Henchir, Jeremy, Ma, Li, Hsia, Carleton J.C, Tisherman, Samuel A

“…Summary Background In a previous study, titration of a hypertonic saline (HTS) solution during severe uncontrolled hemorrhagic shock (UHS) failed to reduce…”
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Resuscitative effects of polynitroxylated αα-cross-linked hemoglobin following severe hemorrhage in the rat by Buehler, Paul W, Mehendale, Sangeeta, Wang, Huashan, Xie, Jingtian, Ma, Li, Trimble, Charles E, Hsia, Carleton J.C, Gulati, Anil

“…αα-Cross-linked hemoglobin (ααHb) is an example of a hemoglobin-based oxygen carrier (HBOC) with significant cardiovascular activity. This may compromise the…”
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Prevention of catecholaminergic oxidative toxicity by 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl and its recycling complex with polynitroxylated albumin, TEMPOL/PNA by Weinberg, Ariella, Nylander, Karen D, Yan, Chaohua, Ma, Li, Hsia, Carleton J.C, Tyurin, Vladimir A, Kagan, Valerian E, Schor, Nina F

“…Reactive oxygen species (ROS) generated from dopamine and its oxidation products have been implicated in the pathogenesis and toxicity from treatment of…”
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Pretreatment with Polynitroxyl Albumin (PNA) Inhibits Ischemia-Reperfusion Induced Leukocyte-Endothelial Cell Adhesion by Russell, Janice, Okayama, Naotsuka, Alexander, J.Steven, Granger, D.Neil, Hsia, Carleton J.C

“…Recently published evidence indicates that polynitroxylated albumin (PNA) protects tissues against ischemia/reperfusion (I/R) injury, possibly by enhancing…”
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Polynitroxyl-albumin (PNA) plus tempol attenuate lung capillary leak elicited by prolonged intestinal ischemia and reperfusion by Zhang, Shu, Li, Haiquan, Ma, Li, Trimble, Charles E, Kuppusamy, Periannan, Hsia, Carleton J.C, Carden, Donna L

“…Stable nitroxyl radicals (nitroxides) are potential antioxidant drugs, and we have previously reported that linking nitroxide to biological macromolecules can…”
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Polynitroxylated hemoglobin-based oxygen carrier: inhibition of free radical-induced microcirculatory dysfunction by Saetzler, Rainer K, Arfors, Karl E, Tuma, Ron F, Vasthare, Usha, Ma, Li, Hsia, Carleton J.C, Lehr, Hans-Anton

“…Reactive oxygen species have been identified as key mediators of leukocyte/endothelial cell interaction under various pathological conditions and diseases such…”
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Neuroprotection with Polynitroxylated PEGylated Hemoglobin as a Macromolecular Superoxide Dismutase/Catalase Mimetic Drug for Resuscitation after Traumatic Brain Injury Combined with Hemorrhage Shock by Koehler, Raymond C., Wang, Jun, Seno, Soichiro, Cao, Suyi, Saraswati, Manda, Hopkins, C. Danielle, Park, Sharon, Simoni, Jan, Ma, Li, Soltys, Bohdan, Hsia, Carleton J.C., Robertson, Courtney L.

“…In polynitroxylated PEGylated hemoglobin (PNPH aka SanFlow), polynitroxylation of hemoglobin confers superoxide dismutase/catalase (SOD/CAT) mimetic activities…”
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Can Macromolecular Nitroxide Work as Extracellular Superoxide Dismutase Mimetic in Cancer and Stroke Therapy? by Hsia, Carleton J. C., Miskimins, W. Keith

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Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles by Soltys, Bohdan J, Grausam, Katie B, Messerli, Shanta M, Hsia, Carleton J C, Zhao, Haotian

“…Medulloblastoma is a tumor of the cerebellum that metastasizes to the leptomeninges of the central nervous system (CNS), including to forebrain and to spinal…”
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Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock by Seno, Soichiro, Wang, Jun, Cao, Suyi, Saraswati, Manda, Park, Sharon, Simoni, Jan, Ma, Li, Soltys, Bohdan, Hsia, Carleton J C, Koehler, Raymond C, Robertson, Courtney L

“…Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from…”
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Can Anti-Metastatic Albumin-based Superoxide Dismutase Mimetic Serve as a “Moonshot” Drug for Treatment for Brain Tumors - From Medulloblastoma to Glioblastoma? by Hsia, Carleton J. C., Messerli, Shanta M., Miskimins, W. Keith

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Polynitroxylated PEGylated hemoglobin protects pig brain neocortical gray and white matter after traumatic brain injury and hemorrhagic shock by Wang, Jun, Shi, Yanrong, Cao, Suyi, Liu, Xiuyun, Martin, Lee J, Simoni, Jan, Soltys, Bohdan J, Hsia, Carleton J C, Koehler, Raymond C

“…Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from…”
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Transfusion of Polynitroxylated Pegylated Hemoglobin Stabilizes Pial Arterial Dilation and Decreases Infarct Volume After Transient Middle Cerebral Artery Occlusion by Cao, Suyi, Zhang, Jian, Ma, Li, Hsia, Carleton J. C., Koehler, Raymond C.

“…Background Polynitroxylation of hemoglobin confers superoxide dismutase–mimetic and peroxidase activity and may protect from reperfusion injury in addition to…”
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Polynitroxylated-Pegylated Hemoglobin Attenuates Fluid Requirements and Brain Edema in Combined Traumatic Brain Injury Plus Hemorrhagic Shock in Mice by Brockman, Erik C, Bayir, Hülya, Blasiole, Brian, Shein, Steven L, Fink, Ericka L, Dixon, C Edward, Clark, Robert SB, Vagni, Vincent A, Ma, Li, Hsia, Carleton JC, Tisherman, Samuel A, Kochanek, Patrick M

“…Polynitroxylated-pegylated hemoglobin (PNPH), a bovine hemoglobin decorated with nitroxide and polyethylene glycol moieties, showed neuroprotection vs…”
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Fast Track Approval of Therapeutic Blood Substitutes by Hsia, Carleton J. C.

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Unusual peroxidase activity of polynitroxylated pegylated hemoglobin: Elimination of H2O2 coupled with intramolecular oxidation of nitroxides by Stoyanovsky, Detcho A., Kapralov, Alexandr, Huang, Zhentai, Maeda, Akihiro, Osipov, Anatoly, Hsia, Carleton J.C., Ma, Li, Kochanek, Patrick M., Bayr, Hulya, Kagan, Valerian E.

“…► Polynitroxylated hemoglobin (Hb) in oxidized and reduced forms exhibit peroxidase activity. ► In plasma, ascorbate reduces polynitroxylated Hb. ► Elimination…”
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