Search Results - "Hryshchuk, Oleksandr V."

3‐Fluoroalkyl (CF3, CHF2, CH2F) Cyclobutane‐Derived Building Blocks for Medicinal Chemistry: Synthesis and Physicochemical Properties by Demchuk, Oleksandr P., Bobovskyi, Bohdan V., Vashchenko, Bohdan V., Hryshchuk, Oleksandr V., Skreminskyi, Artem, Chernykh, Anton V., Moskvina, Viktoriia S., Hordiyenko, Olga V., Volochnyuk, Dmitriy M., Grygorenko, Oleksandr O.

“…Synthesis and physicochemical characterization of all possible cis‐ and trans‐1,3‐disubstituted cyclobutane‐derived amines and carboxylic acids bearing mono‐,…”
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[3+2] Cycloaddition of Alkynyl Boronates and in situ Generated Azomethine Ylide by Liashuk, Oleksandr S., Ryzhov, Ihor A., Hryshchuk, Oleksandr V., Volovenko, Yulian M., Grygorenko, Oleksandr O.

“…Scalable [3+2] cycloaddition of alkynyl boronates and in situ generated unstabilized azomethine ylide is reported for the first time. The selective formation…”
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Photochemical [2 + 2] Cycloaddition of Alkenyl Boronic Derivatives: An Entry into 3‑Azabicyclo[3.2.0]heptane Scaffold by Demchuk, Oleksandr P, Hryshchuk, Oleksandr V, Vashchenko, Bohdan V, Kozytskiy, Andriy V, Tymtsunik, Andriy V, Komarov, Igor V, Grygorenko, Oleksandr O

“…The synthesis of 3-azabicyclo[3.2.0]­heptyl boropinacolates and trifluoroborates via the [2 + 2] photocycloaddition of the corresponding alkenyl boronic…”
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2‐ and 3‐Fluorocyclobutane Building Blocks for Organic and Medicinal Chemistry by Malashchuk, Andrii, Demchuk, Oleksandr P., Razhyk, Bohdan V., Holumbievskyi, Vitalii O., Kudryk, Oleksandr V., Chernykh, Anton V., Hryshchuk, Oleksandr V., Sosunovych, Bohdan S., Volochnyuk, Dmytro M., Vashchenko, Bohdan V., Grygorenko, Oleksandr O.

“…Multigram synthesis of 3‐fluorinated cyclobutane building blocks has been disclosed. The proposed synthetic schemes were based on nucleophilic fluorination and…”
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gem‐Difluorocyclopropanation of Alkenyl Trifluoroborates with the CF3SiMe3–NaI System by Hryshchuk, Oleksandr V., Varenyk, Anatolii O., Yurov, Yevhen, Kuchkovska, Yuliya O., Tymtsunik, Andriy V., Grygorenko, Oleksandr O.

“…Difluorocyclopropanation of alkenyl trifluoroborates using TMSCF3–NaI system was reported for the first time. The developed method allowed preparation of…”
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Synthesis of 3‐Borylated Pyrrolidines by 1,3‐Dipolar Cycloaddition of Alkenyl Boronates and Azomethine Ylide by Liashuk, Oleksandr S., Ryzhov, Ihor A., Hryshchuk, Oleksandr V., Vashchenko, Bohdan V., Melnychuk, Pavlo V., Volovenko, Yulian M., Grygorenko, Oleksandr O.

“…A scalable and efficient process for the preparation of 3‐borylated pyrrolidines by 1,3‐dipolar cycloaddition of N‐benzyl azomethine ylide generated in situ…”
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Bicyclic Pyrrolidines for Medicinal Chemistry via [3 + 2]-Cycloaddition by Savych, Vladimir I, Mykhalchuk, Vladimir L, Melnychuk, Pavlo V, Isakov, Andrii O, Savchuk, Taras, Timoshenko, Vadim M, Siry, Sergiy A, Pavlenko, Sergiy O, Kovalenko, Dmytro V, Hryshchuk, Oleksandr V, Reznik, Vitalii A, Chalyk, Bohdan A, Yarmolchuk, Vladimir S, Rusanov, Eduard B, Mykhailiuk, Pavel K

“…A general approach to bicyclic fused pyrrolidines via [3 + 2]-cycloaddition between nonstabilized azomethyne ylide and endocyclic electron-deficient alkenes…”
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Fluoroalkyl‐Containing 1,2‐Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry by Demchuk, Oleksandr P., Hryshchuk, Oleksandr V., Vashchenko, Bohdan V., Trofymchuk, Serhii A., Melnykov, Kostiantyn P., Skreminskiy, Artem, Volochnyuk, Dmitriy M., Grygorenko, Oleksandr O.

“…Synthesis of previously unavailable 1,2‐disubstituted cyclobutane building blocks bearing mono‐, di‐ and trifluoromethyl groups are disclosed. The key steps…”
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Cyclopropylation of heterocyclic cores using cyclopropylboronic derivatives (microreview) by Grygorenko, Oleksandr O., Hryshchuk, Oleksandr V.

“…Methods for cyclopropane ring incorporation into various heterocyclic cores using cyclopropylsubstituted organoboron compounds are surveyed. In particular,…”
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Synthesis of 3‐Azabicyclo[3.2.0]heptane‐Derived Building Blocks via [3+2] Cycloaddition by Homon, Anton A., Hryshchuk, Oleksandr V., Trofymchuk, Serhii, Michurin, Oleg, Kuchkovska, Yuliya, Radchenko, Dmytro S., Grygorenko, Oleksandr O.

“…An efficient approach to synthesis of various substituted 3‐azabicyclo[3.2.0]heptane‐derived building blocks based on [3+2] cycloaddition of…”
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Far Away from Flatland. Synthesis and Molecular Structure of Dihetera[3.3.n]propellanes and Trihetera[3.3.n]propellanes: Advanced Analogues of Morpholine/Piperazine by Sokolenko, Yevhenii M, Yurov, Yevhen Yu, Vashchenko, Bohdan V, Hryshchuk, Oleksandr V, Filimonova, Yuliia, Ostapchuk, Eugeniy N, Artemenko, Artem, Zaremba, Oleg V, Grygorenko, Oleksandr O

“…An approach to di- and trihetera­[3.3.n]­propellanes (n = 2–4 ), advanced morpholine and piperazine analogues, is developed. The key step of the reaction…”
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Robust and Scalable Approach to 1,3‐Disubstituted Pyridylcyclobutanes by Demchuk, Oleksandr P., Hryshchuk, Oleksandr V., Vashchenko, Bohdan V., Radchenko, Dmytro S., Kovtunenko, Volodymyr O., Komarov, Igor V., Grygorenko, Oleksandr O.

“…An approach to all isomeric 3‐pyridylcyclobutane‐derived building blocks, i.e. ketones, alcohols and amines, is described. Synthesis of the title compounds…”
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2,5-Dihydro-1 H -pyrrol-3-yl Boronic Derivatives: Multigram Synthesis and Coupling Reactions by Liashuk, Oleksandr S., Demchuk, Oleksandr P., Hryshchuk, Oleksandr V., Grygorenko, Oleksandr O.

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2,5-Dihydro‑1H‑pyrrol-3-yl Boronic Derivatives: Multigram Synthesis and Coupling Reactions by Liashuk, Oleksandr S., Demchuk, Oleksandr P., Hryshchuk, Oleksandr V., Grygorenko, Oleksandr O.

“…A protocol for the multigram synthesis of 3-substituted 2,5-dihydro-1H-pyrrole boronic derivatives is reported. The method relied on the triflation of…”
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4,4‐Difluorospiro[2.2]pentan‐1‐yl – A Fluorinated Substituent To Expand the Synthetic and Medicinal Chemists’ Toolbox by Melnykov, Kostiantyn P., Voloshyna, Olena V., Vashchenko, Bohdan V., Demchuk, Oleksandr P., Hryshchuk, Oleksandr V., Grygorenko, Oleksandr O.

“…Functionalized 4,4‐difluorospiro[2.2]pentan‐1‐yl derivatives are proposed as promising building blocks for synthetic and medicinal chemistry. Scalable,…”
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Front Cover: 4,4‐Difluorospiro[2.2]pentan‐1‐yl – A Fluorinated Substituent To Expand the Synthetic and Medicinal Chemists’ Toolbox (Eur. J. Org. Chem. 40/2022) by Melnykov, Kostiantyn P., Voloshyna, Olena V., Vashchenko, Bohdan V., Demchuk, Oleksandr P., Hryshchuk, Oleksandr V., Grygorenko, Oleksandr O.

“…The Front Cover shows novel 4,4‐difluorospiro[2.2]pentan‐1‐yl building blocks as a promising combination of three‐dimensionality, conformational restriction,…”
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4,4‐Difluorospiropentan‐1‐yl – A Fluorinated Substituent To Expand the Synthetic and Medicinal Chemists’ Toolbox by Melnykov, Kostiantyn P, Voloshyna, Olena V, Vashchenko, Bohdan V, Demchuk, Oleksandr P, Hryshchuk, Oleksandr V, Grygorenko, Oleksandr O

“…Functionalized 4,4‐difluorospiro[2.2]pentan‐1‐yl derivatives are proposed as promising building blocks for synthetic and medicinal chemistry. Scalable,…”
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Cover Feature: Synthesis of 3‐Borylated Pyrrolidines by 1,3‐Dipolar Cycloaddition of Alkenyl Boronates and Azomethine Ylide (Chem. Eur. J. 54/2022) by Liashuk, Oleksandr S., Ryzhov, Ihor A., Hryshchuk, Oleksandr V., Vashchenko, Bohdan V., Melnychuk, Pavlo V., Volovenko, Yulian M., Grygorenko, Oleksandr O.

“…1,3‐Dipolar cycloadditions of azomethine ylide (three atoms highlighted in yellow) and a broad scope of alkenyl boronates (the former C=C bond is highlighted…”
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Synthesis of 1,3-bifunctional cyclobutane derivatives with α-CHF2/CF3 group – advanced building blocks for medicinal chemistry by Homon, Anton A., Shynder, Lada V., Demchuk, Oleksandr P., Hryshchuk, Oleksandr V., Kondratov, Ivan S., Gerus, Igor I., Grygorenko, Oleksandr O.

“…•Synthesis of α-CF3/CHF2-substituted 1,3-bifunctional cyclobutanes is described.•Conformationally restricted analogs of γ-amino- and γ-hydroxybutyric acids are…”
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Synthesis of azabicyclo[n.1.0]alkane-derived bifunctional building blocks via the Corey–Chaykovsky cyclopropanation by Yarmoliuk, Dmytro V., Serhiichuk, Dmytro, Smyrnov, Vladyslav, Tymtsunik, Andriy V., Hryshchuk, Oleksandr V., Kuchkovska, Yuliya, Grygorenko, Oleksandr O.

“…[Display omitted] •Synthesis of azabicyclo[5.1.0]octane(methanoazepane)-derived amino acids and diamines is reported.•The Corey–Chaikovsky cyclopropanation is…”
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