Search Results - "Hruzewicz, Witold"

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  1. 1
    Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode:  Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa

    Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode:  Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa by Verner, Erik, Katz, Bradley A, Spencer, Jeffrey R, Allen, Darin, Hataye, Jason, Hruzewicz, Witold, Hui, Hon C, Kolesnikov, Aleksandr, Li, Yong, Luong, Christine, Martelli, Arnold, Radika, Kesavan, Rai, Roopa, She, Miles, Shrader, William, Sprengeler, Paul A, Trapp, Sean, Wang, Jing, Young, Wendy B, Mackman, Richard L

    Published in Journal of medicinal chemistry (16-08-2001)
    “…Novel scaffolds that bind to serine proteases through a unique network of short hydrogen bonds to the catalytic Ser195 have been developed. The resulting…”
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    A Template for Stabilization of a Peptide α-Helix:  Synthesis and Evaluation of Conformational Effects by Circular Dichroism and NMR

    A Template for Stabilization of a Peptide α-Helix:  Synthesis and Evaluation of Conformational Effects by Circular Dichroism and NMR by Austin, Richard E, Maplestone, Rachael A, Sefler, Andrea M, Liu, Kim, Hruzewicz, Witold N, Liu, Corey W, Cho, Ho S, Wemmer, David E, Bartlett, Paul A

    Published in Journal of the American Chemical Society (16-07-1997)
    “…The bicyclic diacid 1 was designed as a semi-rigid template for the hydrogen-bonding pattern of a peptide α-helix. The protected precursor 7 was synthesized in…”
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