Search Results - "Hruz, P."

A new eosinophilic esophagitis (EoE)‐like disease without tissue eosinophilia found in EoE families by Straumann, A., Blanchard, C., Radonjic‐Hoesli, S., Bussmann, Ch, Hruz, P., Safroneeva, E., Simon, D., Schoepfer, A. M., Simon, H.‐U.

“…Background Eosinophilic esophagitis (EoE) is a rapidly emerging, chronic inflammatory, genetically impacted disease of the esophagus, defined clinically by…”
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Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis by Hruz, P, Zimmermann, C, Gutmann, H, Degen, L, Beuers, U, Terracciano, L, Drewe, J, Beglinger, C

“…Background/aims: The apical sodium dependent bile acid transporter ASBT (SLC10A2) contributes substantially to the enterohepatic circulation of bile acids by…”
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The Mechanism of Insulin Resistance Caused by HIV Protease Inhibitor Therapy by Murata, Haruhiko, Hruz, Paul W., Mueckler, Mike

“…Retroviral protease inhibitors used as therapy for HIV-1 infection have been causally associated with serious metabolic side effects, including peripheral…”
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Innate immune defence: NOD2 and autophagy in the pathogenesis of Crohn's disease by Hruz, Petr, Eckmann, Lars

“…Crohn's disease (CD) is a chronic inflammatory disorder of the gut with a poorly understood aetiology. Epidemiological studies suggest that the disease occurs…”
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Structural analysis of the GLUT1 facilitative glucose transporter (review) by Hruz, P W, Mueckler, M M

“…The structure of the human erythrocyte facilitative glucose transporter (GLUT1) has been intensively investigated using a wide array of chemical and…”
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Direct Comparison of the Acute In Vivo Effects of HIV Protease Inhibitors on Peripheral Glucose Disposal by Yan, Qingyun, Hruz, Paul W

“…The clinical use of HIV protease inhibitors (PIs) is associated with the development of peripheral insulin resistance. The incidence and degree of impaired…”
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Cysteine-Scanning Mutagenesis of Transmembrane Segment 11 of the GLUT1 Facilitative Glucose Transporter by Hruz, Paul W, Mueckler, Mike M

“…The glucose permeation pathway within the GLUT1 facilitative glucose transporter is hypothesized to be formed by the juxtaposition of the hydrophilic faces of…”
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Identification of brain structures involved in micturition with functional magnetic resonance imaging (fMRI) by Hruz, P, Lövblad, K.O, Nirkko, A.C, Thoeny, H, El-Koussy, M, Danuser, H

“…Summary Objective The voluntary control of micturition is believed to be integrated by complex interactions among the brainstem, subcortical areas and cortical…”
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Adverse metabolic consequences of HIV protease inhibitor therapy: the search for a central mechanism by Hruz, P W, Murata, H, Mueckler, M

“…Although the clinical introduction of human immunodeficiency virus (HIV) protease inhibitors (PIs) has resulted in a dramatic decline in HIV-related morbidity…”
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Cysteine-scanning Mutagenesis of Transmembrane Segment 7 of the GLUT1 Glucose Transporter by Hruz, P W, Mueckler, M M

“…The human erythrocyte facilitative glucose transporter (Glut1) is predicted to contain 12 transmembrane spanning α-helices based upon hydropathy plot analysis…”
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MON-P148: Dietary Intake of Patients with Inflammatory Bowel Disease by Maissen, S., Caviezel, D., Hruz, P., Kiss, C.

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Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis by Kaya, Berna, Doñas, Cristian, Wuggenig, Philipp, Diaz, Oscar E., Morales, Rodrigo A., Melhem, Hassan, Hernández, Pedro P., Kaymak, Tanay, Das, Srustidhar, Hruz, Petr, Franc, Yannick, Geier, Florian, Ayata, C. Korcan, Villablanca, Eduardo J., Niess, Jan Hendrik

“…Single-nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35 (GPR35) are associated with increased risk of inflammatory bowel disease…”
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3-Hydroxy-3-methylglutaryl-CoA lyase: expression and isolation of the recombinant human enzyme and investigation of a mechanism for regulation of enzyme activity by ROBERTS, J. R, CHAKRAVARTHY NARASIMHAN, HRUZ, P. W, MITCHELL, G. A, MIZIORKO, H. M

“…cDNA encoding the mature form of human hydroxy-methylglutaryl-CoA (HMG-CoA) lyase, a mitochondrial matrix protein, has been used to prepare expression plasmids…”
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P662 Remission to vedolizumab is not higher in TNF-naïve compared with TNF-pre-treated patients with Crohn’s disease by Biedermann, L, Mader, O, Hruz, P, Juillerat, P, Michetti, P, Pittet, V, Rogler, G, Seibold, F

“…Abstract Background Vedolizumab (VDZ) a humanised monoclonal antibody against α4β7 integrin is used in Crohn’s disease (CD) and ulcerative colitis (UC). It is…”
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Intranasal administration of delta sleep-inducing peptide increases P300 by Hruz, P, Zechner, S, Heimberg, D, Hobi, V, Schönenberger, G A, Scheffler, K, Müller-Spahn, F, Seifritz, E

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P063 Representative and comprehensive analysis of colonic and ileac biopsies from IBD patients by gene expression profiling using the straightforward, fast, and affordable novel application Whole Transcriptome AmpliSeq on the Ion Torrent NGS platform by Raulf, F, Roth, L, Delucis-Bronn, C, Begrich, A, Wieczorek, G, Picard, D, Rush, J, Beglinger, C, Hruz, P

“…Abstract Background Whole transcriptome (WT) AmpliSeq analysis of 20803 genes offers significant advantages compared both to hybridisation-based genechip…”
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Avian 3‐hydroxy‐3‐methylglutaryl‐CoA lyase: Sensitivity of enzyme activity to thiol/disulfide exchange and identification of proximal reactive cysteines by Hruz, Paul W., Miziorko, Henry M.

“…Catalysis by purified avian 3‐hydroxy‐3‐methylglutaryl‐CoA lyase is critically dependent on the reduction state of the enzyme, with less than 1% of optimal…”
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Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract by Gutmann, Heike, Hruz, Petr, Zimmermann, Christian, Beglinger, Christoph, Drewe, Juergen

“…Human breast cancer resistance protein (BCRP/ABCG2) is an ABC-transporter that is present on the luminal membrane of intestinal epithelial cells and restricts…”
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3-Hydroxy-3-methylglutaryl coenzyme A lyase: affinity labeling of the Pseudomonas mevalonii enzyme and assignment of cysteine-237 to the active site by Hruz, Paul W, Narasimhan, Chakravarthy, Miziorko, Henry M

“…Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) lyase is irreversibly inactivated by the reactive substrate analog 2-butynoyl-CoA. Enzyme…”
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Mapping of multidrug resistance gene 1 and multidrug resistance-associated protein isoform 1 to 5 mRNA expression along the human intestinal tract by ZIMMERMANN, Christian, GUTMANN, Heike, HRUZ, Petr, GUTZWILLER, Jean-Pierre, BEGLINGER, Christoph, DREWE, Juergen

“…Efflux transporters such as P-glycoprotein and multidrug resistance-associated proteins (MRPs) in the intestinal wall restrict intestinal drug transport. To…”
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