Search Results - "Hruby, V.J"

Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats by Shukla, C, Koch, L.G, Britton, S.L, Cai, M, Hruby, V.J, Bednarek, M, Novak, C.M

“…Highlights • We investigated the role of brain melanocortin receptors (MCRs) in the lean phenotype which shows high physical activity. • Lean rats showed…”
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Fast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group using HCl/dioxane (4 m) by Han, G., Tamaki, M., Hruby, V.J.

“…: Fast, efficient and selective deprotection of the tert‐butoxycarbonyl (Boc) group of various amino acids and peptides was achieved by using hydrogen chloride…”
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Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain by Hruby, V.J, Agnes, R.S, Davis, P, Ma, S.-W, Lee, Y.S, Vanderah, T.W, Lai, J, Porreca, F

“…Disease states such as neuropathic pain offer special challenges in drug design due to the system changes which accompany these diseases. In this manuscript we…”
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Local inhibitory effects of dynorphin A-(1–17) on capsaicin-induced thermal allodynia in rhesus monkeys by Ko, M.C.H, Willmont, K.J, Burritt, A, Hruby, V.J, Woods, J.H

“…Although dynorphin A-(1–17) has been characterized in vitro as a high efficacy κ-opioid receptor agonist, functional studies of dynorphin A-(1–17) following…”
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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome by Fan, W, Boston, B.A, Kesterson, R.A, Hruby, V.J, Cone, R.D

“…Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide,…”
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Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands by Bird, M.F., Vardanyan, R.S., Hruby, V.J., Calò, G., Guerrini, R., Salvadori, S., Trapella, C., McDonald, J., Rowbotham, D.J., Lambert, D.G.

“…Opioid tolerance is a limiting factor in chronic pain. Delta opioid peptide (DOP)(δ) receptor antagonism has been shown to reduce tolerance. Here, the common…”
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Role of central melanocortins in endotoxin-induced anorexia by Huang, Q.H, Hruby, V.J, Tatro, J.B

“…Inflammation and microbial infection produce symptoms, including fever, anorexia, and hypoactivity, that are thought to be mediated by endogenous…”
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Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors by WESSELLS, H, HRUBY, V. J, HACKETT, J, HAN, G, BALSE-SRINIVASAN, P, VANDERAH, T. W

“…Penile erection induced by alpha-melanocyte-stimulating hormone and melanocortin receptors (MC-R) in areas of the spinal cord and periphery has not been…”
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Action of melanin-concentrating hormone (MCH) on teleost chromatophores by Oshima, N, Kasukawa, H, Fujii, R, Wilkes, B C, Hruby, V J, Hadley, M E

“…The in vitro effects of synthetic salmon melanin-concentrating hormone (MCH) on chromatophores of four teleost species were studied. In the erythrophores of…”
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Effects of nonapeptide antagonists on oxytocin- and arginine-vasopressin-induced analgesia in mice by Caldwell, J D, Mason, G A, Stanley, D A, Jerdack, G, Hruby, V J, Hill, P, Prange, Jr, A J, Pedersen, C A

“…Several peptides, including arginine-vasopressin (AVP), neurotensin, and substance P, produce analgesia that is not mediated by opiate systems. Using the hot…”
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The Two NK-1 Binding Sites Correspond to Distinct, Independent, and Non-Interconvertible Receptor Conformational States As Confirmed by Plasmon-Waveguide Resonance Spectroscopy by Alves, Isabel D, Delaroche, Diane, Mouillac, Bernard, Salamon, Zdzislaw, Tollin, Gordon, Hruby, Victor J, Lavielle, Solange, Sagan, Sandrine

“…Two nonstoichiometric ligand binding sites have been previously reported for the NK-1 receptor, with the use of classical methods (radioligand binding and…”
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Plasmon resonance methods in GPCR signaling and other membrane events by Alves, I D, Park, C K, Hruby, V J

“…The existence of surface guided electromagnetic waves has been theoretically predicted from Maxwell's equations and investigated during the first decades of…”
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The effect of halogenation on blood–brain barrier permeability of a novel peptide drug by Gentry, C.L, Egleton, R.D, Gillespie, T, Abbruscato, T.J, Bechowski, H.B, Hruby, V.J, Davis, T.P

“…The utility of a drug depends on its ability to reach appropriate receptors at the target tissue and remain metabolically stable to produce the desired effect…”
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Preparation of 'side-chain-to-side-chain' cyclic peptides by Allyl and Alloc strategy: potential for library synthesis by Grieco, P., Gitu, P.M., Hruby, V.J.

“…: Automated and manual deprotection methods for allyl/allyloxycarbonyl (Allyl/Alloc) were evaluated for the preparation of side‐chain‐to‐side‐chain cyclic…”
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Recipients of Poster Awards at the 24th European Peptide Symposium by Hruby, V.J.

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Plasmon Resonance Studies of Agonist/Antagonist Binding to theHuman δ-Opioid Receptor: New Structural Insights into Receptor-Ligand Interactions by Salamon, Z., Cowell, S., Varga, E., Yamamura, H.I., Hruby, V.J., Tollin, G.

“…Structural changes accompanying the binding of ligands to the cloned human δ-opioid receptor immobilized in a solid-supported lipid bilayer have been…”
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Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-amino-3, 3-diarylpropionic acids by Lin, J., Liao, S., Hruby, V.J.

“…:  A series of optically pure, conformationally constrained, and highly hydrophobic unusual aromatic amino acids, 2‐amino‐3,3‐diarylpropionic acids, were…”
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Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R by Haskell-Luevano, C, Miwa, H, Dickinson, C, Hruby, V J, Yamada, T, Gantz, I

“…Binding and stimulation of cAMP by the melanotropin peptides alpha-MSH (alpha-melanocyte-stimulating hormone) and its superpotent analogues [Nle4,…”
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Dynamical search for bis-penicillamine enkephalin conformations by Pettitt, B.M., Matsunaga, T., al-Obeidi, F., Gehrig, C., Hruby, V.J., Karplus, M.

“…Quenched molecular dynamics is used as a conformational search technique for the constrained cyclic analog [D-Pen2,D-Pen5]enkephalin (DPDPE) in a continuum…”
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Effect of peptide conformation on membrane permeability by Boguslavsky, V., Hruby, V.J., O'Brien, D.F., Misicka, A., Lipkowski, A.W.

“…: The effect of peptide conformational constraint on the peptide permeation across the model membranes was examined by determining the permeability of pairs of…”
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