Search Results - "Hromadkova, Lenka"

Tau-Reactive Endogenous Antibodies: Origin, Functionality, and Implications for the Pathophysiology of Alzheimer’s Disease by Hromadkova, Lenka, Ovsepian, Saak Victor

“…In Alzheimer’s disease (AD), tau pathology manifested in the accumulation of intraneuronal tangles and soluble toxic oligomers emerges as a potential…”
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Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels by Schedin-Weiss, Sophia, Inoue, Mitsuhiro, Hromadkova, Lenka, Teranishi, Yasuhiro, Yamamoto, Natsuko Goto, Wiehager, Birgitta, Bogdanovic, Nenad, Winblad, Bengt, Sandebring-Matton, Anna, Frykman, Susanne, Tjernberg, Lars O

“…Increased levels of the pathogenic amyloid β-peptide (Aβ), released from its precursor by the transmembrane protease γ-secretase, are found in Alzheimer…”
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Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer’s disease tau by Hromadkova, Lenka, Kim, Chae, Haldiman, Tracy, Peng, Lihua, Zhu, Xiongwei, Cohen, Mark, de Silva, Rohan, Safar, Jiri G

“…Abstract Objectives Although accumulation of misfolded tau species has been shown to predict cognitive decline in patients with Alzheimer’s disease (AD) and…”
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Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer's Disease and Related Dementias by Hromadkova, Lenka, Siddiqi, Mohammad Khursheed, Liu, He, Safar, Jiri G

“…Recent findings of diverse populations of prion-like conformers of misfolded tau protein expand the prion concept to Alzheimer's disease (AD) and monogenic…”
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Cellular Biology of Tau Diversity and Pathogenic Conformers by Kang, Sang-Gyun, Eskandari-Sedighi, Ghazaleh, Hromadkova, Lenka, Safar, Jiri G., Westaway, David

“…Tau accumulation is a prominent feature in a variety of neurodegenerative disorders and remarkable effort has been expended working out the biochemistry and…”
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Interactions of 17β-Hydroxysteroid Dehydrogenase Type 10 and Cyclophilin D in Alzheimer's Disease by Kristofikova, Zdenka, Springer, Tomas, Gedeonova, Erika, Hofmannova, Adéla, Ricny, Jan, Hromadkova, Lenka, Vyhnalek, Martin, Laczo, Jan, Nikolai, Tomas, Hort, Jakub, Petrasek, Tomas, Stuchlik, Ales, Vales, Karel, Klaschka, Jan, Homola, Jiri

“…The nucleus-encoded 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) regulates cyclophilin D (cypD) in the mitochondrial matrix. CypD regulates opening of…”
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Characterization of isolated tau-reactive antibodies from the IVIG product, plasma of patients with Alzheimer's disease and cognitively normal individuals by Krestova, Michala, Hromadkova, Lenka, Bilkova, Zuzana, Bartos, Ales, Ricny, Jan

“…The presence of natural tau-reactive antibodies was reported in human blood. In this study, we isolated and characterized natural tau-reactive antibodies…”
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Purification of Natural Antibodies Against Tau Protein by Affinity Chromatography by Krestova, Michala, Hromadkova, Lenka, Ricny, Jan

“…Natural antibodies are now widely studied for their therapeutical potential. Therefore, their isolation and subsequent characterization is desired. Here, we…”
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Brain-derived neurotrophic factor (BDNF) promotes molecular polarization and differentiation of immature neuroblastoma cells into definitive neurons by Hromadkova, Lenka, Bezdekova, Dagmar, Pala, Jan, Schedin-Weiss, Sophia, Tjernberg, Lars O., Hoschl, Cyril, Ovsepian, Saak V.

“…Throughout development, neuronal progenitors undergo complex transformation into polarized nerve cells, warranting the directional flow of information in the…”
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Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product by Hromadkova, Lenka, Kolarova, Michala, Jankovicova, Barbora, Bartos, Ales, Ricny, Jan, Bilkova, Zuzana, Ripova, Daniela

“…Abstract The latest therapeutic approaches to Alzheimer disease are using intravenous immunoglobulin (IVIG) products. Therefore, the detailed characterization…”
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Kinase-loaded magnetic beads for sequential in vitro phosphorylation of peptides and proteins by Hromadkova, Lenka, Kupcik, Rudolf, Vajrychova, Marie, Prikryl, Petr, Charvatova, Andrea, Jankovicova, Barbora, Ripova, Daniela, Bilkova, Zuzana, Slovakova, Marcela

“…Post-translational modifications, including phosphorylation, greatly impact the physiological function of proteins, especially those that are natively unfolded…”
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INTRANEURONAL AMYLOID β-PEPTIDE LEVELS ARE AFFECTED BY MONOAMINE OXIDASE B by Winblad, Bengt, Hromadkova, Lenka, Frykman, Susanne, Tjernberg, Lars O., Weiss, Sophia Schedin

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Difficulties associated with the structural analysis of proteins susceptible to form aggregates: The case of Tau protein as a biomarker of Alzheimer's disease by Hromadkova, Lenka, Kupcik, Rudolf, Jankovicova, Barbora, Rousar, Tomas, Ripova, Daniela, Bilkova, Zuzana

“…Mass spectrometry coupled with bioaffinity separation techniques is considered a powerful tool for studying protein interactions. This work is focused on…”
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Corrigendum to “Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product” [J. Neuroimmunol. 289 (2015) 121–129] by Hromadkova, Lenka, Kolarova, Michala, Jankovicova, Barbora, Bartos, Ales, Ricny, Jan, Bilkova, Zuzana, Ripova, Daniela

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Immunoaffinity purification and characterization of specific antibodies against recombinant tau protein from intravenous immunoglobulin product by Hromadkova, Lenka, Kolarova, Michala, Jankovicova, Barbora, Bartos, Ales, Ricny, Jan, Bilkova, Zuzana, Ripova, Daniela

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Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with [gamma]-secretase and regulates neuronal amyloid [beta]-peptide levels by Schedin-Weiss, Sophia, Inoue, Mitsuhiro, Hromadkova, Lenka, Teranishi, Yasuhiro, Yamamoto, Natsuko Goto, Wiehager, Birgitta, Bogdanovic, Nenad, Winblad, Bengt, Sandebring-Matton, Anna, Frykman, Susanne, Tjernberg, Lars O

“…Background Increased levels of the pathogenic amyloid [beta]-peptide (A[beta]), released from its precursor by the transmembrane protease [gamma]-secretase,…”
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