Search Results - "Hrnčiarová, Tereza"
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Lipidomic profiling of human serum enables detection of pancreatic cancer
Published in Nature communications (10-01-2022)“…Pancreatic cancer has the worst prognosis among all cancers. Cancer screening of body fluids may improve the survival time prognosis of patients, who are often…”
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Serum neurofilament light chain reflects inflammation-driven neurodegeneration and predicts delayed brain volume loss in early stage of multiple sclerosis
Published in Multiple sclerosis (01-01-2021)“…Background: Serum neurofilament light chain (sNfL) is a marker of neuroaxonal injury. There is a lack of studies investigating the dynamics of relationships…”
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Propensity Score Weighting Using Overlap Weights: A New Method Applied to Regorafenib Clinical Data and a Cost-Effectiveness Analysis
Published in Value in health (01-12-2019)“…In situations of markedly different population characteristics and weak population overlap, inverse propensity score (PS) weights suffer from extreme values…”
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Peripheral gene signatures reveal distinct cancer patient immunotypes with therapeutic implications for autologous DC-based vaccines
Published in Oncoimmunology (31-12-2022)“…Dendritic cells (DCs) have received considerable attention as potential targets for the development of novel cancer immunotherapies. However, the clinical…”
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Safety and efficacy of dendritic cell-based immunotherapy DCVAC/OvCa added to first-line chemotherapy (carboplatin plus paclitaxel) for epithelial ovarian cancer: a phase 2, open-label, multicenter, randomized trial
Published in Journal for immunotherapy of cancer (01-01-2022)“…BackgroundMost patients with epithelial ovarian cancer (EOC) relapse despite primary debulking surgery and chemotherapy (CT). Autologous dendritic cell…”
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Brainstem lesions are associated with diffuse spinal cord involvement in early multiple sclerosis
Published in BMC neurology (19-07-2022)“…Background Early infratentorial and focal spinal cord lesions on magnetic resonance imaging (MRI) are associated with a higher risk of long-term disability in…”
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An Autologous Dendritic Cell Vaccine Promotes Anticancer Immunity in Patients with Ovarian Cancer with Low Mutational Burden and Cold Tumors
Published in Clinical cancer research (15-07-2022)“…PURPOSEThe successful implementation of immune checkpoint inhibitors (ICI) in the clinical management of various solid tumors has raised considerable…”
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Dendritic cell-based immunotherapy (DCVAC/OvCa) combined with second-line chemotherapy in platinum-sensitive ovarian cancer (SOV02): A randomized, open-label, phase 2 trial
Published in Gynecologic oncology (01-09-2021)“…DCVAC/OvCa is an active cellular immunotherapy designed to stimulate an immune response against ovarian cancer. We explored the safety and efficacy of…”
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Dendritic cell vaccine (DCVAC) combined with chemotherapy (CMT) in patients with newly diagnosed epithelial ovarian carcinoma (EOC) after primary debulking surgery (PDS): Biomarker exploratory analysis of a phase 2, open-label, randomized, multicenter trial
Published in Journal of clinical oncology (20-05-2021)“…Abstract only 5521 Background: Most patients with EOC relapse despite PDS and CMT. Autologous DCVAC can present tumor antigens to elicit a durable immune…”
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To be or not to be vaccinated: The risk of MS or NMOSD relapse after COVID-19 vaccination and infection
Published in Multiple sclerosis and related disorders (01-09-2022)“…•There is an increase in the MS relapse incidence after COVID-19 infection.•There is a mild increase in the MS relapse incidence after COVID-19…”
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Mapping Quality of Life (EQ-5D) from DAPsA, Clinical DAPsA and HAQ in Psoriatic Arthritis
Published in The patient : patient-centered outcomes research (01-06-2018)“…Background Clinical trials and observational studies lacking measures of health-related quality of life (QoL) are often inapplicable when conducting…”
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Does initial high efficacy therapy in multiple sclerosis surpass escalation treatment strategy? A comparison of patients with relapsing-remitting multiple sclerosis in the Czech and Swedish national multiple sclerosis registries
Published in Multiple sclerosis and related disorders (01-08-2023)“…•Direct initiation of moderate-high efficacy therapy seems beneficial.•Moderate-high efficacy therapy does not lead to treatment switch due to adverse…”
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