Search Results - "Hrdinka, Matous"

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling by Elliott, Paul R., Leske, Derek, Hrdinka, Matous, Bagola, Katrin, Fiil, Berthe K., McLaughlin, Stephen H., Wagstaff, Jane, Volkmar, Norbert, Christianson, John C., Kessler, Benedikt M., Freund, Stefan M.V., Komander, David, Gyrd-Hansen, Mads

“…The linear ubiquitin chain assembly complex (LUBAC) regulates immune signaling, and its function is regulated by the deubiquitinases OTULIN and CYLD, which…”
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The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma by Vdovin, Alexander, Jelinek, Tomas, Zihala, David, Sevcikova, Tereza, Durech, Michal, Sahinbegovic, Hana, Snaurova, Renata, Radhakrishnan, Dhwani, Turi, Marcello, Chyra, Zuzana, Popkova, Tereza, Venglar, Ondrej, Hrdinka, Matous, Hajek, Roman, Simicek, Michal

“…Serum monoclonal immunoglobulin (Ig) is the main diagnostic factor for patients with multiple myeloma (MM), however its prognostic potential remains unclear…”
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Deubiquitinase BAP1 is crucial for surface expression of T cell receptor (TCR) complex, T cell-B cell conjugate formation, and T cell activation by Radhakrishnan, Dhwani, Kotulová, Jana, Hofmanová, Lucie, Sithara, Anjana Anilkumar, Turi, Marcello, Žihala, David, Ďurech, Michal, Vrána, Jan, Uleri, Valeria, Niederlova, Veronika, Stepanek, Ondrej, Chyra, Zuzana, Jelínek, Tomáš, Hájek, Roman, Hrdinka, Matous

“…The adaptive immune response critically hinges on the functionality of T cell receptors (TCRs), governed by complex molecular mechanisms, including…”
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Intercellular Mitochondrial Transfer in the Tumor Microenvironment by Sahinbegovic, Hana, Jelinek, Tomas, Hrdinka, Matous, Bago, Juli R., Turi, Marcello, Sevcikova, Tereza, Kurtovic-Kozaric, Amina, Hajek, Roman, Simicek, Michal

“…Cell-to-cell communication is a fundamental process in every multicellular organism. In addition to membrane-bound and released factors, the sharing of…”
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A Bird's-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers by Motais, Benjamin, Charvátová, Sandra, Hrdinka, Matouš, Šimíček, Michal, Jelínek, Tomáš, Ševčíková, Tereza, Kořístek, Zdeněk, Hájek, Roman, Bagó, Juli R

“…Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements…”
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SCIMP, a Transmembrane Adaptor Protein Involved in Major Histocompatibility Complex Class II Signaling by Draber, Peter, Vonkova, Ivana, Stepanek, Ondrej, Hrdinka, Matous, Kucova, Marketa, Skopcova, Tereza, Otahal, Pavel, Angelisova, Pavla, Horejsi, Vaclav, Yeung, Mandy, Weiss, Arthur, Brdicka, Tomas

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis by Chyra, Zuzana, Sevcikova, Tereza, Vojta, Petr, Puterova, Janka, Brozova, Lucie, Growkova, Katerina, Filipova, Jana, Zatopkova, Martina, Grosicki, Sebastian, Barchnicka, Agnieszka, Jedrzejczak, Wieslaw Wiktor, Waszczuk-Gajda, Anna, Jungova, Alexandra, Mikulasova, Aneta, Hajduch, Marian, Mokrejs, Martin, Pour, Ludek, Stork, Martin, Harvanova, Lubica, Mistrik, Martin, Mikala, Gabor, Robak, Pawel, Czyz, Anna, Debski, Jakub, Usnarska-Zubkiewicz, Lidia, Jurczyszyn, Artur, Stejskal, Lukas, Morgan, Gareth, Kryukov, Fedor, Budinska, Eva, Simicek, Michal, Jelinek, Tomas, Hrdinka, Matous, Hajek, Roman

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The transmembrane region is responsible for targeting of adaptor protein LAX into "heavy rafts" by Hrdinka, Matous, Otahal, Pavel, Horejsi, Vaclav

“…The importance of membrane compartmentalization into specific membrane microdomains has been shown in many biological processes such as immunoreceptor…”
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PB2397: TRANSCRIPTOME ANALYSIS OF DIFFUSE LARGE B‐CELL LYMPHOMA CELLS EXPRESSING MYD88 L265P REVEALS CD44, LGALS3, NFKBIZ AND BATF AS DOWNSTREAM TARGETS OF ONCOGENIC NF‐ΚB SIGNALING by Turi, Marcello, Anilkumar Sithara, Anjana, Hofmanová, Lucie, Žihala, David, Radhakrishnan, Dhwani, Vdovin, Alexander, Knápková, Sofija, Ševčíková, Tereza, Chyra, Zuzana, Jelínek, Tomas, Šimíček, Michal, Gullà, Annamaria, Anderson, Kenneth, Hájek, Roman, Hrdinka, Matous

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CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling by Hrdinka, Matous, Fiil, Berthe Katrine, Zucca, Mattia, Leske, Derek, Bagola, Katrin, Yabal, Monica, Elliott, Paul R., Damgaard, Rune Busk, Komander, David, Jost, Philipp J., Gyrd-Hansen, Mads

“…Innate immune signaling relies on the deposition of non-degradative polyubiquitin at receptor-signaling complexes, but how these ubiquitin modifications are…”
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P805: EXTRAMEDULLARY MULTIPLE MYELOMA: MOLECULAR PATHOGENESIS AND NOVEL THERAPEUTIC TARGETS by Zihala, David, Jelinek, Tomas, Sevcikova, Tereza, Anilkumar Sithara, Anjana, Kapustova, Veronika, Bilek, Daniel, Sahinbegovic, Hana, Popkova, Tereza, Plonkova, Hana, Broskevicova, Lucie, Venglar, Ondrej, Vrana, Jan, Zidlik, Vladimir, Havel, Martin, Koristek, Zdenek, Hrdinka, Matous, Chyra, Zuzana, Simicek, Michal, Hajek, Roman

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Normal Development and Function of T Cells in Proline Rich 7 (Prr7) Deficient Mice by Hrdinka, Matous, Sudan, Kritika, Just, Sissy, Drobek, Ales, Stepanek, Ondrej, Schlüter, Dirk, Reinhold, Dirk, Jordan, Bryen A, Gintschel, Patricia, Schraven, Burkhart, Kreutz, Michael R

“…Transmembrane adaptor proteins (TRAPs) are important organisers for the transduction of immunoreceptor-mediated signals. Prr7 is a TRAP that regulates T cell…”
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A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling by Otahal, Pavel, Angelisova, Pavla, Hrdinka, Matous, Brdicka, Tomas, Novak, Petr, Drbal, Karel, Horejsi, Vaclav

“…Membrane rafts and signaling molecules associated with them are thought to play important roles in immunoreceptor signaling. Rafts differ in their lipid and…”
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Acute intermittent porphyria - impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties by Ulbrichova, Dana, Hrdinka, Matous, Saudek, Vladimir, Martasek, Pavel

“…Acute intermittent porphyria is an autosomal dominantly inherited disorder, classified as acute hepatic porphyria, caused by a deficiency of…”
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Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine by Zátopková, Martina, Ševčíková, Tereza, Fanfani, Viola, Chyra, Zuzana, Říhová, Lucie, Bezděková, Renata, Žihala, David, Growková, Kateřina, Filipová, Jana, Černá, Lucie, Broskevičova, Lucie, Kryukov, Fedor, Minařík, Jiří, Smejkalová, Jana, Maisnar, Vladimír, Harvanová, Ĺubica, Pour, Luděk, Jungova, Alexandra, Popková, Tereza, Bago, Juli Rodriguez, Anilkumar Sithara, Anjana, Hrdinka, Matouš, Jelínek, Tomáš, Šimíček, Michal, Stracquadanio, Giovanni, Hájek, Roman

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The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation by Hrdinka, Matous, Gyrd-Hansen, Mads

“…The linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked polyubiquitin (also…”
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Inhibitor of apoptosis proteins in human health and disease by Hrdinka, Matous, Yabal, Monica

“…The inhibitor of apoptosis proteins (IAPs) are best known for their ability to regulate cell survival and death processes. However, in addition to cell death,…”
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PRR7 Is a Transmembrane Adaptor Protein Expressed in Activated T Cells Involved in Regulation of T Cell Receptor Signaling and Apoptosis by Hrdinka, Matouš, Dráber, Peter, Štěpánek, Ondřej, Ormsby, Tereza, Otáhal, Pavel, Angelisová, Pavla, Brdička, Tomáš, Pačes, Jan, Hořejší, Václav, Drbal, Karel

“…Transmembrane adaptor proteins (TRAPs) are important organizers and regulators of immunoreceptor-mediated signaling. A bioinformatic search revealed several…”
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Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility by Celichowski, Piotr, Turi, Marcello, Charvátová, Sandra, Radhakrishnan, Dhwani, Feizi, Neda, Chyra, Zuzana, Šimíček, Michal, Jelínek, Tomáš, Bago, Juli Rodriguez, Hájek, Roman, Hrdinka, Matouš

“…Cancer immunotherapies utilizing genetically engineered T cells have emerged as powerful personalized therapeutic agents showing dramatic preclinical and…”
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Membrane microdomains in immunoreceptor signaling by Horejsi, Vaclav, Hrdinka, Matous

“…Membrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been implicated in T-cell receptor (TCR), and more generally immunoreceptor,…”
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