Search Results - "Hrabinova, M."

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease by Hepnarova, V., Korabecny, J., Matouskova, L., Jost, P., Muckova, L., Hrabinova, M., Vykoukalova, N., Kerhartova, M., Kucera, T., Dolezal, R., Nepovimova, E., Spilovska, K., Mezeiova, E., Pham, N.L., Jun, D., Staud, F., Kaping, D., Kuca, K., Soukup, O.

“…Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed based on multi-target directed ligands (MTLDs) paradigm, synthesized and…”
Get full text

Pralidoxime--the gold standard of acetylcholinesterase reactivators--reactivation in vitro efficacy by Kuca, K, Hrabinova, M, Soukup, O, Tobin, G, Karasova, J, Pohanka, M

“…In this work, we aim to summarize the universality of this compound, its reactivation potential when different cholinesterase inhibitors are used. Pralidoxime…”
Get more information

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings by Kuca, Kamil, Karasova, Jana Zdarova, Soukup, Ondrej, Kassa, Jiri, Novotna, Eva, Sepsova, Vendula, Horova, Anna, Pejchal, Jaroslav, Hrabinova, Martina, Vodakova, Eva, Jun, Daniel, Nepovimova, Eugenie, Valis, Martin, Musilek, Kamil

“…Intoxication by nerve agents could be prevented by using small acetylcholinesterase inhibitors (eg, pyridostigmine) for potentially exposed personnel. However,…”
Get full text

Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model by Pohanka, Miroslav, Hrabinova, Martina, Zemek, Filip, Drtinova, Lucie, Bandouchova, Hana, Pikula, Jiri

“…Alzheimer's disease (AD) is a neurodegenerative disorder. Symptomatic treatment is available by inhibitors of acetylcholinesterase (AChE) such as rivastigmine,…”
Get more information

Russian VX: Inhibition and Reactivation of Acetylcholinesterase Compared with VX Agent by Kuca, Kamil, Jun, Daniel, Cabal, Jiri, Hrabinova, Martina, Bartosova, Lucie, Opletalova, Veronika

“…: Organophosphorus compounds such as nerve agents inhibit, practically irreversibly, cholinesterases by their phosphorylation in the active site of these…”
Get full text

Potency of Five Structurally Different Acetylcholinesterase Reactivators to Reactivate Human Brain Cholinesterases Inhibited by Cyclosarin by Kuca, Kamil, Cabal, Jiri, Jun, Daniel, Hrabinova, Martina

“…Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators are used as a part of the antidotal therapy of organophosphorus pesticide and nerve agent intoxications…”
Get full text

In Vitro Potency of H Oximes (HI-6, HLö-7), the Oxime BI-6, and Currently Used Oximes (Pralidoxime, Obidoxime, Trimedoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by Kuca, Kamil, Cabal, Jiri, Kassa, Jiri, Jun, Daniel, Hrabinova, Martina

“…The efficacy of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate acetylcholinesterase…”
Get full text

Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain by Kuca, Kamil, Cabal, Jiri, Kassa, Jiri, Jun, Daniel, Hrabinová, Martina

“…The potency of currently used oximes to reactivate sarin‐inhibited acetylcholinesterase (AChE) in various parts of pig brain and whole pig brain was evaluated…”
Get full text

A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun by Cabal, J, Kuca, K, Jun, D, Bajgar, J, Hrabinová, M

“…The nerve agent tabun inhibits acetylcholinesterase (AChE; EC 3.1.1.7) by the formation of a covalent bond with the enzyme. Afterwards, AChE is not able to…”
Get more information