Search Results - "Hrabĕ de Angelis, M"

A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue by Fischer, I P, Irmler, M, Meyer, C W, Sachs, S J, Neff, F, Hrabě de Angelis, M, Beckers, J, Tschöp, M H, Hofmann, S M, Ussar, S

“…Background/Objectives: Dieting is a popular yet often ineffective way to lower body weight, as the majority of people regain most of their pre-dieting weights…”
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Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs by Tomar, A., Gomez-Velazquez, M., Gerlini, R., Comas-Armangué, G., Makharadze, L., Kolbe, T., Boersma, A., Dahlhoff, M., Burgstaller, J. P., Lassi, M., Darr, J., Toppari, J., Virtanen, H., Kühnapfel, A., Scholz, M., Landgraf, K., Kiess, W., Vogel, M., Gailus-Durner, V., Fuchs, H., Marschall, S., Hrabě de Angelis, M., Kotaja, N., Körner, A., Teperino, R.

“…Spermatozoa harbour a complex and environment-sensitive pool of small non-coding RNAs (sncRNAs) 1 , which influences offspring development and adult phenotypes…”
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A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice by Ryan, D P, Henzel, K S, Pearson, B L, Siwek, M E, Papazoglou, A, Guo, L, Paesler, K, Yu, M, Müller, R, Xie, K, Schröder, S, Becker, L, Garrett, L, Hölter, S M, Neff, F, Rácz, I, Rathkolb, B, Rozman, J, Ehninger, G, Klingenspor, M, Klopstock, T, Wolf, E, Wurst, W, Zimmer, A, Fuchs, H, Gailus-Durner, V, Hrabě de Angelis, M, Sidiropoulou, K, Weiergräber, M, Zhou, Y, Ehninger, D

“…Dietary intake of methyl donors, such as folic acid and methionine, shows considerable intra-individual variation in human populations. While it is recognized…”
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Identification of biomarkers for apoptosis in cancer cell lines using metabolomics: tools for individualized medicine by Halama, A., Riesen, N., Möller, G., Hrabě de Angelis, M., Adamski, J.

“…Background Metabolomics is a versatile unbiased method to search for biomarkers of human disease. In particular, one approach in cancer therapy is to promote…”
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Inflammation and mitochondrial fatty acid β-oxidation link obesity to early tumor promotion by Khasawneh, J, Schulz, M.D, Walch, A, Rozman, J, de Angelis, M. Hrabe, Klingenspor, M, Buck, A, Schwaiger, M, Saur, D, Schmid, R.M, Klöppel, G, Sipos, B, Greten, F.R, Arkan, M.C

“…Obesity is associated with increased risk for developing pancreatic cancer, and it is suggested that insulin resistance provides the missing link. Here we…”
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EMPReSS: standardized phenotype screens for functional annotation of the mouse genome by Brown, S D M, Chambon, P, de Angelis, M Hrabé

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Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice by Kiefer, F. W., Neschen, S., Pfau, B., Legerer, B., Neuhofer, A., Kahle, M., Hrabé de Angelis, M., Schlederer, M., Mair, M., Kenner, L., Plutzky, J., Zeyda, M., Stulnig, T. M.

“…Aims/hypothesis Obesity is strongly associated with the development of non-alcoholic fatty liver disease (NAFLD). The cytokine osteopontin (OPN) was recently…”
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Genetic characterization of a mouse line with primary aldosteronism by Perez-Rivas, L G, Rhayem, Y, Sabrautzki, S, Hantel, C, Rathkolb, B, Hrabě de Angelis, M, Reincke, M, Beuschlein, F, Spyroglou, A

“…In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism, a mutagenesis screen after treatment with the alkylating…”
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Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms by Eißmann, M, Melzer, I M, Fernández, S B M, Michel, G, Hrabě de Angelis, M, Hoefler, G, Finkenwirth, P, Jauch, A, Schoell, B, Grez, M, Schmidt, M, Bartholomae, C C, Newrzela, S, Haetscher, N, Rieger, M A, Zachskorn, C, Mittelbronn, M, Zörnig, M

“…AVEN has been identified as an inhibitor of apoptosis, which binds to the adaptor protein, APAF-1, and thereby prevents apoptosome formation and mitochondrial…”
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Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity by Gerlini, R., Berti, L., Darr, J., Lassi, M., Brandmaier, S., Fritsche, L., Scheid, F., Böhm, A., Königsrainer, A., Grallert, H., Häring, H.U., Hrabě de Angelis, M., Staiger, H., Teperino, R.

“…Although debated, metabolic health characterizes 10–25% of obese individuals and reduces risk of developing life-threatening co-morbidities. Adipose tissue is…”
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DJ‐1‐deficient mice show less TH‐positive neurons in the ventral tegmental area and exhibit non‐motoric behavioural impairments by Pham, T. T., Giesert, F., Röthig, A., Floss, T., Kallnik, M., Weindl, K., Hölter, S. M., Ahting, U., Prokisch, H., Becker, L., Klopstock, T., Hrabé de Angelis, M., Beyer, K., Görner, K., Kahle, P. J., Vogt Weisenhorn, D. M., Wurst, W.

“…Loss of function of DJ‐1 (PARK7) is associated with autosomal recessive early‐onset Parkinson's disease (PD), one of the major age‐related neurological…”
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High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice by Kahle, M, Schäfer, A, Seelig, A, Schultheiß, J, Wu, M, Aichler, M, Leonhardt, J, Rathkolb, B, Rozman, J, Sarioglu, H, Hauck, S.M, Ueffing, M, Wolf, E, Kastenmueller, G, Adamski, J, Walch, A, Hrabé de Angelis, M, Neschen, S

“…Abstract Objective Excess lipid intake has been implicated in the pathophysiology of hepatosteatosis and hepatic insulin resistance. Lipids constitute…”
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Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice by Kistler, M, Szymczak, W, Fedrigo, M, Fiamoncini, J, Höllriegl, V, Hoeschen, C, Klingenspor, M, Hrabě de Angelis, M, Rozman, J

“…Breath gas analysis in humans proved successful in identifying disease states and assessing metabolic functions in a non-invasive way. While many studies…”
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Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich GckD217V mutants by van Buerck, L., Schuster, M., Rathkolb, B., Sabrautzki, S., Hrabě de Angelis, M., Wolf, E., Aigner, B., Wanke, R., Herbach, N.

“…► Hyperglycaemic mouse strain from the Munich ENU mouse mutagenesis project. ► We identified and characterised a novel mutation in exon 6 of the glucokinase…”
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Identification of Coexpressed Gene Clusters in a Comparative Analysis of Transcriptome and Proteome in Mouse Tissues by Mijalski, T., Harder, A., Halder, T., Kersten, M., Horsch, M., Strom, T. M., Liebscher, H. V., Lottspeich, F., de Angelis, M. Hrabě, Beckers, J., Jaenisch, Rudolf

“…A major advantage of the mouse model lies in the increasing information on its genome, transcriptome, and proteome, as well as in the availability of a fast…”
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Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring by Dahlhoff, M., Pfister, S., Blutke, A., Rozman, J., Klingenspor, M., Deutsch, M.J., Rathkolb, B., Fink, B., Gimpfl, M., Hrabě de Angelis, M., Roscher, A.A., Wolf, E., Ensenauer, R.

“…Vulnerability of the fetus upon maternal obesity can potentially occur during all developmental phases. We aimed at elaborating longer-term health outcomes of…”
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Linking disease-associated genes to regulatory networks via promoter organization by Döhr, S., Klingenhoff, A., Maier, H., de Angelis, M. Hrabé, Werner, T., Schneider, R.

“…Pathway- or disease-associated genes may participate in more than one transcriptional co-regulation network. Such gene groups can be readily obtained by…”
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Deletion of Glucose Transporter GLUT8 in Mice Increases Locomotor Activity by Schmidt, S., Gawlik, V., Hölter, S. M., Augustin, R., Scheepers, A., Behrens, M., Wurst, W., Gailus-Durner, V., Fuchs, H., de Angelis, M. Hrabé, Kluge, R., Joost, H.-G., Schürmann, A.

“…Transport of glucose into neuronal cells is predominantly mediated by the glucose transporters GLUT1 and GLUT3. In addition, GLUT8 is expressed in some regions…”
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Novel lymphocyte-independent mechanisms to initiate inflammatory arthritis via bone marrow-derived cells of Ali18 mutant mice by Abe, K., Wechs, S., Kalaydjiev, S., Franz, T. J., Busch, D. H., Fuchs, H., Soewarto, D., Behrendt, H., Wagner, S., Jakob, T., Hrabé de Angelis, M.

“…Objective. In a large-scale ENU (N-ethyl-N-nitrosourea) mouse mutagenesis programme, we previously have identified and characterized a novel mutation Ali18…”
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Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2) by van Bürck, L, Blutke, A, Kautz, S, Rathkolb, B, Klaften, M, Wagner, S, Kemter, E, Hrabé de Angelis, M, Wolf, E, Aigner, B, Wanke, R, Herbach, N

“…Several mutant mouse models for human diseases such as diabetes mellitus have been generated in the large-scale Munich ENU (N-ethyl-N-nitrosourea) mouse…”
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