Search Results - "Hoyos, Valentina"

Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects by Shafer, Paul, Kelly, Lauren M, Hoyos, Valentina

“…To redirect T cells against tumor cells, T cells can be engineered to express cancer-antigen specific T cell receptors (TCRs), generating products known as…”
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Predictive Biomarkers of Immune Checkpoint Inhibitor Response in Breast Cancer: Looking beyond Tumoral PD-L1 by Chen, Nan, Higashiyama, Nicole, Hoyos, Valentina

“…Immune checkpoint inhibitors utilize the immune system to kill cancer cells and are now widely applied across numerous malignancies. Pembrolizumab has two…”
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Selectively targeting myeloid-derived suppressor cells through TRAIL receptor 2 to enhance the efficacy of CAR T cell therapy for treatment of breast cancer by Nalawade, Saisha A, Shafer, Paul, Bajgain, Pradip, McKenna, Mary K, Ali, Arushana, Kelly, Lauren, Joubert, Jarrett, Gottschalk, Stephen, Watanabe, Norihiro, Leen, Ann, Parihar, Robin, Vera Valdes, Juan Fernando, Hoyos, Valentina

“…BackgroundSuccessful targeting of solid tumors such as breast cancer (BC) using chimeric antigen receptor (CAR) T cells has proven challenging, largely…”
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CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation by Bajgain, Pradip, Tawinwung, Supannikar, D'Elia, Lindsey, Sukumaran, Sujita, Watanabe, Norihiro, Hoyos, Valentina, Lulla, Premal, Brenner, Malcolm K, Leen, Ann M, Vera, Juan F

“…The adoptive transfer of T cells redirected to tumor via chimeric antigen receptors (CARs) has produced clinical benefits for the treatment of hematologic…”
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Immunotherapy of Metastatic Melanoma Using Genetically Engineered GD2-Specific T cells by YVON, Eric, DEL VECCHIO, Michele, SAVOLDO, Barbara, HOYOS, Valentina, DUTOUR, Aurélie, ANICHINI, Andrea, DOTTI, Gianpietro, BRENNER, Malcolm K

“…Purpose: Genetic engineering of human T lymphocytes to express tumor-directed chimeric antigen receptors (CAR) can produce antitumor effector cells that bypass…”
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Multi-antigen-targeted T-cell therapy to treat patients with relapsed/refractory breast cancer by Hoyos, Valentina, Vasileiou, Spyridoula, Kuvalekar, Manik, Watanabe, Ayumi, Tzannou, Ifigeneia, Velazquez, Yovana, French-Kim, Matthew, Leung, Wingchi, Lulla, Suhasini, Robertson, Catherine, Foreman, Claudette, Wang, Tao, Bulsara, Shaun, Lapteva, Natalia, Grilley, Bambi, Ellis, Matthew, Osborne, Charles Kent, Coscio, Angela, Nangia, Julie, Heslop, Helen E., Rooney, Cliona M., Vera, Juan F., Lulla, Premal, Rimawi, Mothaffar, Leen, Ann M.

“…Purpose: Adoptively transferred, ex vivo expanded multi-antigen-targeted T cells (multiTAA-T) represent a new, potentially effective, and nontoxic therapeutic…”
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Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas by Arnone, Claudia Manuela, Polito, Vinicia Assunta, Mastronuzzi, Angela, Carai, Andrea, Diomedi, Francesca Camassei, Antonucci, Laura, Petrilli, Lucia Lisa, Vinci, Maria, Ferrari, Francesco, Salviato, Elisa, Scarsella, Marco, De Stefanis, Cristiano, Weber, Gerrit, Quintarelli, Concetta, De Angelis, Biagio, Brenner, Malcolm K, Gottschalk, Stephen, Hoyos, Valentina, Locatelli, Franco, Caruana, Ignazio, Del Bufalo, Francesca

“…BackgroundPediatric high-grade gliomas (pHGGs) are among the most common and incurable malignant neoplasms of childhood. Despite aggressive, multimodal…”
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Genetic modification of human T lymphocytes for the treatment of hematologic malignancies by HOYOS, Valentina, SAVOLDO, Barbara, DOTTI, Gianpietro

“…Modern chemotherapy regimens and supportive care have produced remarkable improvements in the overall survival of patients with hematologic malignancies…”
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Lumpectomy followed by radiation improves survival in HER2 positive and triple‐negative breast cancer with high tumor‐infiltrating lymphocytes compared to mastectomy alone by Mouabbi, Jason A., Chand, Momal, Asghar, Ishaq A., Sakhi, Ramen, Ockner, Daniel, Dul, Carrie L., Hadid, Tarik, Aref, Amr, Rimawi, Mothaffar F., Hoyos, Valentina

“…Objective The goal was to compare the 5‐year DFS and 5‐year OS in patients with early‐stage human epidermal growth factor receptor 2 breast cancer (HER2+ BC)…”
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Dose-reduced trastuzumab deruxtecan can be safely used in liver failure and active leptomeningeal metastases by Higashiyama, Nicole, Nangia, Julie, Shafaee, Maryam Nemati, Chen, Nan, Michael, Binu Liz, Rimawi, Mothaffar, Hoyos, Valentina

“…Trastuzumab deruxtecan has been shown to have responses in heavily pretreated patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic…”
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Multiple mechanisms determine the sensitivity of human-induced pluripotent stem cells to the inducible caspase-9 safety switch by Yagyu, Shigeki, Hoyos, Valentina, Del Bufalo, Francesca, Brenner, Malcolm K

“…Expression of the inducible caspase-9 (iC9) suicide gene is one of the most appealing safety strategies for cell therapy and has been applied for human-induced…”
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The immunotherapy era of myeloma: monoclonal antibodies, vaccines, and adoptive T-cell therapies by Hoyos, Valentina, Borrello, Ivan

“…The treatment of multiple myeloma has evolved significantly over the last decades from primarily alkylator-based chemotherapeutic agents with minimal efficacy…”
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Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes by Caruana, Ignazio, Savoldo, Barbara, Hoyos, Valentina, Weber, Gerrit, Liu, Hao, Kim, Eugene S, Ittmann, Michael M, Marchetti, Dario, Dotti, Gianpietro

“…Gianpietro Dotti and colleagues report that CAR-T cells expressing heparanase to degrade the extracellular matrix may enhance their infiltration of and effects…”
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Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors by Nishio, Nobuhiro, Diaconu, Iulia, Liu, Hao, Cerullo, Vincenzo, Caruana, Ignazio, Hoyos, Valentina, Bouchier-Hayes, Lisa, Savoldo, Barbara, Dotti, Gianpietro

“…The clinical efficacy of chimeric antigen receptor (CAR)-redirected T cells remains marginal in solid tumors compared with leukemias. Failures have been…”
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Crisis en el sistema de fuentes del derecho internacional: el SOFT LAW en el derecho penal internacional y el derecho penal colombiano by Gómez Pavajeau, Carlos Arturo, Hoyos Otálvaro, Valentina, Posada Martínez, Martín

“…El soft law es una fuente del derecho internacional que influye en el derecho penal internacional y en el sistema penal colombiano. La evolución del derecho…”
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Abstract P2-08-14: Effect of markers of systemic inflammation on tumor infiltrating lymphocytes in patients with non-metastatic triple negative and HER2+ breast cancer: A single center retrospective study by Chen, Nan, Bulsara, Shaun, Hilsenbeck, Susan, Hoyos, Valentina

“…Abstract Background: Tumor infiltrating lymphocytes (TILs) are increasingly being recognized as a vital component of the tumor immune microenvironment. TILs…”
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An Inducible Caspase-9 Suicide Gene to Improve the Safety of Therapy Using Human Induced Pluripotent Stem Cells by Yagyu, Shigeki, Hoyos, Valentina, Del Bufalo, Francesca, Brenner, Malcolm K

“…Human induced pluripotent stem cells (hiPSC) hold promise for regenerative therapies, though there are several safety concerns including the risk of oncogenic…”
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Frequency of coprescription and potential risk of bronchospasm in Colombian patients users of topical antiglaucomatous betablockers and bronchodilators by Machado-Alba, Jorge Enrique, Hoyos-Soto, Valentina

“…Background: Cardiovascular and respiratory effects of adrenergic agonists used in diseases like chronic obstructive pulmonary disease (COPD), and β-blockers…”
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Mesenchymal stromal cell delivery of oncolytic immunotherapy improves CAR-T cell antitumor activity by McKenna, Mary K., Englisch, Alexander, Brenner, Benjamin, Smith, Tyler, Hoyos, Valentina, Suzuki, Masataka, Brenner, Malcolm K.

“…The immunosuppressive tumor microenvironment (TME) is a formidable barrier to the success of adoptive cell therapies for solid tumors. Oncolytic immunotherapy…”
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Toxicidad sistemica por anestesicos locales by Quintana Puerta, Julian Esteban, Cifuentes Hoyos, Valentina

“…Los anestésicos locales son medicamentos de uso generalizado y, aunque se consideran seguros, ocasionalmente pueden producir toxicidad con alteración del…”
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