Search Results - "Hoyer, Stefanie"

RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma by Harrer, Dennis C, Simon, Bianca, Fujii, Shin-Ichiro, Shimizu, Kanako, Uslu, Ugur, Schuler, Gerold, Gerer, Kerstin F, Hoyer, Stefanie, Dörrie, Jan, Schaft, Niels

“…Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial…”
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BRAF and MEK Inhibitors Affect Dendritic-Cell Maturation and T-Cell Stimulation by Hoyer, Stefanie, Eberlein, Valentina, Schuler, Gerold, Berking, Carola, Heinzerling, Lucie, Schaft, Niels, Dörrie, Jan

“…BRAF and MEK inhibitor (BRAFi/MEKi) combinations are currently the standard treatment for patients with BRAF mutant metastatic melanoma. Since the…”
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BRAF and MEK Inhibitors Influence the Function of Reprogrammed T Cells: Consequences for Adoptive T-Cell Therapy by Dörrie, Jan, Babalija, Lek, Hoyer, Stefanie, Gerer, Kerstin F, Schuler, Gerold, Heinzerling, Lucie, Schaft, Niels

“…BRAF and MEK inhibitors (BRAFi/MEKi), the standard treatment for patients with BRAF mutated melanoma, are currently explored in combination with various…”
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Targeted label‐free quantification of interleukin‐8 in PMA‐activated U937 cell secretome by nanoLC‐ESI‐MS/MS‐sSRM by Emirbayer, Pelin Esma, Gerer, Kerstin F., Hoyer, Stefanie, Pischetsrieder, Monika

“…Monocytes are a part of the innate immune system. Their differentiation into macrophages changes their cellular proteome and secretome. Particularly secretome…”
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Preclinical evaluation of NF-κB-triggered dendritic cells expressing the viral oncogenic driver of Merkel cell carcinoma for therapeutic vaccination by Gerer, Kerstin F., Erdmann, Michael, Hadrup, Sine R., Lyngaa, Rikke, Martin, Lena-Marie, Voll, Reinhard E., Schuler-Thurner, Beatrice, Schuler, Gerold, Schaft, Niels, Hoyer, Stefanie, Dörrie, Jan

“…Background: Merkel cell carcinoma (MCC) is a rare but very aggressive skin tumor that develops after integration of a truncated form of the large T-antigen…”
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Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells by Vera, Julio, Schaft, Niels, Dörrie, Jan, Cavalieri, Duccio, Beltrame, Luca, Jaitly, Tanushree, Höfflin, Sandra, Prommersberger, Sabrina, Pfeiffer, Isabell A., Gerer, Kerstin F., Hoyer, Stefanie, Schuler, Gerold

“…For therapeutic cancer vaccination, the adoptive transfer of mRNA-electroporated dendritic cells (DCs) is frequently performed, usually with monocyte-derived,…”
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Electroporation of mRNA as Universal Technology Platform to Transfect a Variety of Primary Cells with Antigens and Functional Proteins by Gerer, Kerstin F, Hoyer, Stefanie, Dörrie, Jan, Schaft, Niels

“…Electroporation (EP) of mRNA into human cells is a broadly applicable method to transiently express proteins of choice in a variety of different cell types. We…”
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Concurrent interaction of DCs with CD4+ and CD8+ T cells improves secondary CTL expansion: It takes three to tango by Hoyer, Stefanie, Prommersberger, Sabrina, Pfeiffer, Isabell A., Schuler‐Thurner, Beatrice, Schuler, Gerold, Dörrie, Jan, Schaft, Niels

“…T‐cell help is essential for CTL‐memory formation. Nevertheless, it is unclear whether the continuous presence of CD4+ T‐helper (Th) cells is required during…”
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Laying the foundation for a core set of the International Classification of Functioning, Disability and Health for community-dwelling adults aged 75 years and above in general practice: a study protocol by Tomandl, Johanna, Book, Stephanie, Gotthardt, Susann, Heinmueller, Stefan, Graessel, Elmar, Freiberger, Ellen, Kuehlein, Thomas, Hueber, Susann, Hoyer, Stefanie

“…IntroductionWith the medical focus on disease, the problem of overdiagnosis inevitably increases with ageing. Considering the functional health of patients…”
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Proteomic Response of Human Umbilical Vein Endothelial Cells to Histamine Stimulation by Emirbayer, Pelin Esma, Sinha, Ankit, Ignatchenko, Vladimir, Hoyer, Stefanie, Dörrie, Jan, Schaft, Niels, Pischetsrieder, Monika, Kislinger, Thomas

“…The histamine receptors (HRs) represent a subclass of G protein‐coupled receptors (GPCRs) and comprise four subtypes. Due to their numerous physiological and…”
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Electroporation of mRNA as a Universal Technology Platform to Transfect a Variety of Primary Cells with Antigens and Functional Proteins by Sauerer, Tatjana, Albrecht, Leoni, Sievers, Nico M, Gerer, Kerstin F, Hoyer, Stefanie, Dörrie, Jan, Schaft, Niels

“…Electroporation (EP) of mRNA into human cells is a broadly applicable method to transiently express proteins of choice in a variety of different cell types. We…”
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Triggering of NF‐κB in cytokine‐matured human DCs generates superior DCs for T‐cell priming in cancer immunotherapy by Pfeiffer, Isabell A., Hoyer, Stefanie, Gerer, Kerstin F., Voll, Reinhard E., Knippertz, Ilka, Gückel, Eva, Schuler, Gerold, Schaft, Niels, Dörrie, Jan

“…Understanding the signaling that governs the immunogenicity of human dendritic cells (DCs) is a prerequisite for improving DC‐based therapeutic vaccination…”
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Concurrent interaction of DCs with CD4 super(+) and CD8 super(+) T cells improves secondary CTL expansion: It takes three to tango by Hoyer, Stefanie, Prommersberger, Sabrina, Pfeiffer, Isabell A, Schuler-Thurner, Beatrice, Schuler, Gerold, Dorrie, Jan, Schaft, Niels

“…T-cell help is essential for CTL-memory formation. Nevertheless, it is unclear whether the continuous presence of CD4 super(+) T-helper (Th) cells is required…”
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RNA-transfection of [gamma]/[delta] T cells with a chimeric antigen receptor or an [alpha]/[beta] T-cell receptor: a safer alternative to genetically engineered [alpha]/[beta] T cells for the immunotherapy of melanoma by Harrer, Dennis C, Simon, Bianca, Fujii, Shin-ichiro, Shimizu, Kanako, Uslu, Ugur, Schuler, Gerold, Gerer, Kerstin F, Hoyer, Stefanie, Dörrie, Jan, Schaft, Niels

“…Background Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused…”
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Triggering of NF-[kappa]B in cytokine-matured human DCs generates superior DCs for T-cell priming in cancer immunotherapy by Pfeiffer, Isabell A, Hoyer, Stefanie, Gerer, Kerstin F, Voll, Reinhard E, Knippertz, Ilka, Guckel, Eva, Schuler, Gerold, Schaft, Niels, Dorrie, Jan

“…Understanding the signaling that governs the immunogenicity of human dendritic cells (DCs) is a prerequisite for improving DC-based therapeutic vaccination…”
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Preclinical evaluation of NF-κB-triggered dendritic cells expressing theviral oncogenic driver of Merkel cell carcinoma for therapeuticvaccination by Gerer, Kerstin F, Erdmann, Michael, Hadrup, Sine R, Lyngaa Rikke, Lena-Marie, Martin, Voll, Reinhard E, Schuler-Thurner, Beatrice, Schuler Gerold, Schaft Niels, Hoyer, Stefanie, Dörrie, Jan

“…Background: Merkel cell carcinoma (MCC) is a rare but very aggressive skin tumor that developsafter integration of a truncated form of the large T-antigen…”
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A fast and robust method to clone and functionally validate T-cell receptors by Birkholz, Katrin, Hofmann, Christian, Hoyer, Stefanie, Schulz, Birgit, Harrer, Thomas, Kämpgen, Eckhart, Schuler, Gerold, Dörrie, Jan, Schaft, Niels

“…Sequencing, cloning and functional testing of T-cell-receptor (TCR) α- and β-chains from T-cell clones is often required in immunotherapy and in immunological…”
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