Search Results - "Howson, Patrick A."

Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization by Lennon, Siân M., Rivero, Guadalupe, Matharu, Annelise, Howson, Patrick A., Jane, David E., Roberts, Peter J., Kelly, Eamonn

“…To investigate the susceptibility of the group II metabotropic glutamate receptor mGlu2 to agonist-induced desensitization, the receptor was stably expressed…”
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Non-steric-zipper models for pathogenic α-synuclein conformers by Schuman, Brock, Won, Amy, Brand-Arzamendi, Koroboshka, Koprich, James B., Wen, Xiao-Yan, Howson, Patrick A., Brotchie, Jonathan M., Yip, Christopher M.

“…Parkinson's disease neurodegenerative brain tissue exhibits two biophysically distinct α-synuclein fiber isoforms—single stranded fibers that appear to be…”
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Beneficial Effects of Trehalose on Striatal Dopaminergic Deficits in Rodent and Primate Models of Synucleinopathy in Parkinson's Disease by Howson, Patrick A, Johnston, Tom H, Ravenscroft, Paula, Hill, Michael P, Su, Jin, Brotchie, Jonathan M, Koprich, James B

“…Disease modification in Parkinson's disease (PD) is an unmet medical need. In the current study, we evaluated trehalose, a safe and well-tolerated disaccharide…”
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DPI-289, a novel mixed delta opioid agonist / mu opioid antagonist (DAMA), has L-DOPA-sparing potential in Parkinson's disease by Johnston, Tom H., Versi, Eboo, Howson, Patrick A., Ravenscroft, Paula, Fox, Susan H., Hill, Michael P., Reidenberg, Bruce E., Corey, Ronald, Brotchie, Jonathan M.

“…L-DOPA-induced dyskinesia (LID) remains a significant problem in the management of Parkinson's disease (PD). In rodent and macaque models of PD, delta opioid…”
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The link between mitochondrial complex I and brain-derived neurotrophic factor in SH-SY5Y cells – The potential of JNX1001 as a therapeutic agent by Kim, Helena K., Mendonça, Karina M., Howson, Patrick A., Brotchie, Jonathan M., Andreazza, Ana C.

“…Mitochondrial complex I, which is the first member of the electron transport chain responsible for producing ATP, can produce reactive oxygen species and…”
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PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease by Visanji, Naomi P., Orsi, Antonia, Johnston, Tom H., Howson, Patrick A., Dixon, Kimberly, Callizot, Noelle, Brotchie, Jonathan M., Rees, Daryl D.

“…ABSTRACT Many experimental data support the enhancement of neurotrophic factors as a means to modify neurodegeneration in Parkinson's disease. However, the…”
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Actions of LY341495 on metabotropic glutamate receptor‐mediated responses in the neonatal rat spinal cord by Howson, Patrick A, Jane, David E

“…The group II metabotropic glutamate (mGlu) receptor antagonist (2S,1′S,2′S)‐2‐(2‐carboxycyclopropyl)‐2‐(9H‐xanthen‐9‐yl)glycine (LY341495) also has activity at…”
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( S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord by Thomas, Nicola K, Wright, Rebecca A, Howson, Patrick A, Kingston, Ann E, Schoepp, Darryle D, Jane, David E

“…( S)-3,4-Dicarboxyphenylglycine (DCPG) has been tested on cloned human mGlu1–8 receptors individually expressed in AV12-664 cells co-expressing a rat…”
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Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals by Miller, Jacqueline C, Howson, Patrick A, Conway, Stuart J, Williams, Richard V, Clark, Barry P, Jane, David E

“…Three novel phenylglycine analogues; (RS)‐α‐methyl‐3‐chloro‐4‐phosphonophenylglycine (UBP1110), (RS)‐α‐methyl‐3‐methoxy‐4‐phosphonophenylglycine (UBP1111) and…”
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Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors by Conway, Stuart J, Miller, Jacqueline C, Howson, Patrick A, Clark, Barry P, Jane, David E

“…The syntheses of a range of ring and α-substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4– 10…”
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