Search Results - "Howson, Lauren J."

MR1-Restricted Mucosal-Associated Invariant T Cells and Their Activation during Infectious Diseases by Howson, Lauren J, Salio, Mariolina, Cerundolo, Vincenzo

“…MR1-restricted mucosal-associated invariant T (MAIT) cells recognize vitamin B metabolites, which are generated by a broad range of bacteria, from Escherichia…”
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Insights into mucosal associated invariant T cell biology from human inborn errors of immunity by Howson, Lauren J, Bryant, Vanessa L

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MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A by Howson, Lauren J., Napolitani, Giorgio, Shepherd, Dawn, Ghadbane, Hemza, Kurupati, Prathiba, Preciado-Llanes, Lorena, Rei, Margarida, Dobinson, Hazel C., Gibani, Malick M., Teng, Karen Wei Weng, Newell, Evan W., Veerapen, Natacha, Besra, Gurdyal S., Pollard, Andrew J., Cerundolo, Vincenzo

“…Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can detect bacteria-derived metabolites presented on MR1. Here we show, using a…”
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Cytomegalovirus drives Vδ1+ γδ T cell expansion and clonality in common variable immunodeficiency by Chan, Samantha, Morgan, Benjamin, Yong, Michelle K., Margetts, Mai, Farchione, Anthony J., Lucas, Erin C., Godsell, Jack, Giang, Nhi Ai, Slade, Charlotte A., von Borstel, Anouk, Bryant, Vanessa L., Howson, Lauren J.

“…The function and phenotype of γδ T cells in the context of common variable immunodeficiency (CVID) has not been explored. CVID is a primary immunodeficiency…”
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Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells by Timosenko, Elina, Ghadbane, Hemza, Silk, Jonathan D, Shepherd, Dawn, Gileadi, Uzi, Howson, Lauren J, Laynes, Robert, Zhao, Qi, Strausberg, Robert L, Olsen, Lars R, Taylor, Stephen, Buffa, Francesca M, Boyd, Richard, Cerundolo, Vincenzo

“…Tryptophan degradation is an immune escape strategy shared by many tumors. However, cancer cells' compensatory mechanisms remain unclear. We demonstrate here…”
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Case Report: Cytomegalovirus Disease Is an Under-Recognized Contributor to Morbidity and Mortality in Common Variable Immunodeficiency by Chan, Samantha, Godsell, Jack, Horton, Miles, Farchione, Anthony, Howson, Lauren J, Margetts, Mai, Jin, Celina, Chatelier, Josh, Yong, Michelle, Sasadeusz, Joseph, Douglass, Jo A, Slade, Charlotte A, Bryant, Vanessa L

“…Common Variable Immunodeficiency (CVID) is classified as a 'Predominantly Antibody Deficiency' (PAD), but there is emerging evidence of cellular…”
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Immunology of a Transmissible Cancer Spreading among Tasmanian Devils by Woods, Gregory M, Howson, Lauren J, Brown, Gabriella K, Tovar, Cesar, Kreiss, Alexandre, Corcoran, Lynn M, Lyons, A Bruce

“…Devil facial tumor disease (DFTD) is a transmissible cancer that has killed most of the Tasmanian devil (Sarcophilus harrissii) population. Since the first…”
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Recognition of the antigen-presenting molecule MR1 by a Vδ3⁺ γδ T cell receptor by Rice, Michael T., von Borstel, Anouk, Chevour, Priyanka, Awad, Wael, Howson, Lauren J., Littler, Dene R., Gherardin, Nicholas A., Le Nours, Jérôme, Giles, Edward M., Berry, Richard, Godfrey, Dale I., Davey, Martin S., Rossjohn, Jamie, Gully, Benjamin S.

“…Unlike conventional αβ T cells, γδ T cells typically recognize non-peptide ligands independently of major histocompatibility complex (MHC) restriction…”
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Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways by Kurioka, Ayako, van Wilgenburg, Bonnie, Javan, Reza Rezaei, Hoyle, Ryan, van Tonder, Andries J, Harrold, Caroline L, Leng, Tianqi, Howson, Lauren J, Shepherd, Dawn, Cerundolo, Vincenzo, Brueggemann, Angela B, Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells represent an innate T-cell population that can recognize ligands generated by the microbial riboflavin synthesis…”
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Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire by von Borstel, Anouk, Chevour, Priyanka, Arsovski, Daniel, Krol, Jelte M M, Howson, Lauren J, Berry, Andrea A, Day, Cheryl L, Ogongo, Paul, Ernst, Joel D, Nomicos, Effie Y H, Boddey, Justin A, Giles, Edward M, Rossjohn, Jamie, Traore, Boubacar, Lyke, Kirsten E, Williamson, Kim C, Crompton, Peter D, Davey, Martin S

“…Repeated infections drive the development of clinical immunity to malaria in humans; however, the immunological mechanisms that underpin this response are only…”
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Mucosal-Associated Invariant T Cell Effector Function Is an Intrinsic Cell Property That Can Be Augmented by the Metabolic Cofactor α-Ketoglutarate by Howson, Lauren J, Li, Jasmine, von Borstel, Anouk, Barugahare, Adele, Mak, Jeffrey Y W, Fairlie, David P, McCluskey, James, Turner, Stephen J, Davey, Martin S, Rossjohn, Jamie

“…Mucosal-associated invariant T (MAIT) cells are an innate-like population of unconventional T cells that respond rapidly to microbial metabolite Ags or…”
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Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals by von Borstel, Anouk, Nguyen, Thi Ho, Rowntree, Louise C, Ashhurst, Thomas M, Allen, Lilith F, Howson, Lauren J, Holmes, Natasha E, Smibert, Olivia C, Trubiano, Jason A, Gordon, Claire L, Cheng, Allen C, Kent, Stephen J, Rossjohn, Jamie, Kedzierska, Katherine, Davey, Martin S

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a small proportion of infected…”
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Human B Cell Receptor Repertoire Sequencing by Kotagiri, Prasanti, Bashford-Rogers, Rachael J M, Bryant, Vanessa L, Howson, Lauren J

“…Next-generation sequencing has the potential to uncover the complex nature of B cell immunity by revealing the full complexity of B cell receptor (BCR)…”
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Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1 by Howson, Lauren J, Awad, Wael, von Borstel, Anouk, Lim, Hui Jing, McWilliam, Hamish E G, Sandoval-Romero, Maria L, Majumdar, Shamik, Hamzeh, Abdul Rezzak, Andrews, Thomas D, McDermott, David H, Murphy, Philip M, Le Nours, Jérôme, Mak, Jeffrey Y W, Liu, Ligong, Fairlie, David P, McCluskey, James, Villadangos, Jose A, Cook, Matthew C, Turner, Stephen J, Davey, Martin S, Ojaimi, Samar, Rossjohn, Jamie

“…The role unconventional T cells play in protective immunity in humans is unclear. Mucosal-associated invariant T (MAIT) cells are an unconventional T cell…”
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Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells by Teh, Charis E., Peng, Hongke, Luo, Meng-Xiao, Tan, Tania, Trussart, Marie, Howson, Lauren J., Chua, Chong Chyn, Muttiah, Christine, Brown, Fiona, Ritchie, Matthew E., Wei, Andrew H., Roberts, Andrew W., Bryant, Vanessa L., Anderson, Mary Ann, Lindeman, Geoffrey J., Huang, David C. S., Thijssen, Rachel, Gray, Daniel H. D.

“…•Multiomic single-cell analysis of 3 different patient cohorts reveals few changes in T and NK cells following venetoclax monotherapy.•The data support the…”
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Identification of dendritic cells, B cell and T cell subsets in Tasmanian devil lymphoid tissue; evidence for poor immune cell infiltration into devil facial tumors by Howson, Lauren J., Morris, Katrina M., Kobayashi, Takumi, Tovar, Cesar, Kreiss, Alexandre, Papenfuss, Anthony T., Corcoran, Lynn, Belov, Katherine, Woods, Gregory M.

“…ABSTRACT The Tasmanian devil is under threat of extinction due to the transmissible devil facial tumor disease (DFTD). This fatal tumor is an allograft that…”
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Case Report: Cytomegalovirus Disease Is an Under-Recognized Contributor to Morbidity and Mortality in Common Variable Immunodeficiency by Chan, Samantha, Godsell, Jack, Horton, Miles, Farchione, Anthony, Howson, Lauren J, Margetts, Mai, Jin, Celina, Chatelier, Josh, Yong, Michelle, Sasadeusz, Joseph, Douglass, Jo A, Slade, Charlotte A, Bryant, Vanessa L

“…BACKGROUNDCommon Variable Immunodeficiency (CVID) is classified as a 'Predominantly Antibody Deficiency' (PAD), but there is emerging evidence of cellular…”
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