Search Results - "Howlett, K"

Derivation of pluripotent epiblast stem cells from mammalian embryos by Trotter, Matthew W. B, Howlett, Sarah K, Sun, Bowen, Clarkson, Amanda, Smithers, Lucy E, Pedersen, Roger A, Brons, I. Gabrielle M, Ahrlund-Richter, Lars, Rugg-Gunn, Peter, Chuva de Sousa Lopes, Susana M, Vallier, Ludovic

“…Although the first mouse embryonic stem (ES) cell lines were derived 25 years ago using feeder-layer-based blastocyst cultures, subsequent efforts to extend…”
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Cross-tissue immune cell analysis reveals tissue-specific features in humans by Domínguez Conde, C, Xu, C, Jarvis, L B, Rainbow, D B, Wells, S B, Gomes, T, Howlett, S K, Suchanek, O, Polanski, K, King, H W, Mamanova, L, Huang, N, Szabo, P A, Richardson, L, Bolt, L, Fasouli, E S, Mahbubani, K T, Prete, M, Tuck, L, Richoz, N, Tuong, Z K, Campos, L, Mousa, H S, Needham, E J, Pritchard, S, Li, T, Elmentaite, R, Park, J, Rahmani, E, Chen, D, Menon, D K, Bayraktar, O A, James, L K, Meyer, K B, Yosef, N, Clatworthy, M R, Sims, P A, Farber, D L, Saeb-Parsy, K, Jones, J L, Teichmann, S A

“…Despite their crucial role in health and disease, our knowledge of immune cells within human tissues remains limited. We surveyed the immune compartment of 16…”
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Impact of exercise training status on the fiber type-specific abundance of proteins regulating intramuscular lipid metabolism by Shaw, C S, Swinton, C, Morales-Scholz, M G, McRae, N, Erftemeyer, T, Aldous, A, Murphy, R M, Howlett, K F

“…Endurance training enhances the capacity for fat oxidation during exercise due to increased utilization of intramuscular lipid (IMCL). This study…”
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FlowAtlas: an interactive tool for high-dimensional immunophenotyping analysis bridging FlowJo with computational tools in Julia by Coppard, Valerie, Szep, Grisha, Georgieva, Zoya, Howlett, Sarah K, Jarvis, Lorna B, Rainbow, Daniel B, Suchanek, Ondrej, Needham, Edward J, Mousa, Hani S, Menon, David K, Feyertag, Felix, Mahbubani, Krishnaa T, Saeb-Parsy, Kourosh, Jones, Joanne L

“…As the dimensionality, throughput and complexity of cytometry data increases, so does the demand for user-friendly, interactive analysis tools that leverage…”
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Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73 by Jarvis, Lorna B., Rainbow, Daniel B., Coppard, Valerie, Howlett, Sarah K., Georgieva, Zoya, Davies, Jessica L., Mullay, Harpreet Kaur, Hester, Joanna, Ashmore, Tom, Van Den Bosch, Aletta, Grist, James T., Coles, Alasdair J., Mousa, Hani S., Pluchino, Stefano, Mahbubani, Krishnaa T., Griffin, Julian L., Saeb-Parsy, Kourosh, Issa, Fadi, Peruzzotti-Jametti, Luca, Wicker, Linda S., Jones, Joanne L.

“…The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell…”
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A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease by Peterson, Laurence B., Bell, Charles J.M., Howlett, Sarah K., Pekalski, Marcin L., Brady, Kevin, Hinton, Heather, Sauter, Denise, Todd, John A., Umana, Pablo, Ast, Oliver, Waldhauer, Inja, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Klein, Christian, Hosse, Ralf J., Wicker, Linda S.

“…Susceptibility to multiple autoimmune diseases is associated with common gene polymorphisms influencing IL-2 signaling and Treg function, making Treg-specific…”
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Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species by Rainbow, Dan B, Esposito, Laura, Howlett, Sarah K, Hunter, Kara M, Todd, John A, Peterson, Laurence B, Wicker, Linda S

“…Variants within the IL-2 (interleukin 2) and CD25 genes are associated with T1DM (Type 1 diabetes mellitus) in mice and humans respectively. Both gene products…”
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Does Point-of-Care Ultrasonography Improve Clinical Outcomes in Emergency Department Patients With Undifferentiated Hypotension? An International Randomized Controlled Trial From the SHoC-ED Investigators by Atkinson, Paul R., Milne, James, Diegelmann, Laura, Lamprecht, Hein, Stander, Melanie, Lussier, David, Pham, Chau, Henneberry, Ryan, Fraser, Jacqueline M., Howlett, Michael K., Mekwan, Jayanand, Ramrattan, Brian, Middleton, Joanna, van Hoving, Daniel J., Peach, Mandy, Taylor, Luke, Dahn, Tara, Hurley, Sean, MacSween, Kayla, Richardson, Luke R., Stoica, George, Hunter, Samuel, Olszynski, Paul A., Lewis, David A.

“…Point-of-care ultrasonography protocols are commonly used in the initial management of patients with undifferentiated hypotension in the emergency department…”
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Methylation levels of maternal and paternal genomes during preimplantation development by HOWLETT, S. K, REIK, W

“…The methylation status of three highly repeated sequences was studied in sperm, eggs and preimplantation embryos with different combinations of parental…”
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Adrenaline and glycogenolysis in skeletal muscle during exercise: a study in adrenalectomised humans by Kjaer, M, Howlett, K, Langfort, J, Zimmerman-Belsing, T, Lorentsen, J, Bulow, J, Ihlemann, J, Feldt-Rasmussen, U, Galbo, H

“…The role of adrenaline in regulating muscle glycogenolysis and hormone-sensitive lipase (HSL) activity during exercise was examined in six adrenaline-deficient…”
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Integrated emergency, critical, and operative care: A coordinated approach to strengthening emergency care and health service delivery by Tupesis, Janis P., Bonney, Joseph, Connolly, Jim, Howlett, Michael K., Kang, Christopher, Convocar, Pauline, Lai King, Lauren, Skinner, Clare, López Tapia, Daniel, Davies, Ffion

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A Method for Reviewing the Accuracy and Reliability of a Five-Level Triage Process (Canadian Triage and Acuity Scale) in a Community Emergency Department Setting: Building the Crowding Measurement Infrastructure by Howlett, Michael K., Atkinson, Paul R. T.

“…Objectives. Triage data are widely used to evaluate patient flow, disease severity, and emergency department (ED) workload, factors used in ED crowding…”
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Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney by LAMONT, B. J, ANDRIKOPOULOS, S, FUNKAT, A, FAVALORO, J, YE, J. M, KRAEGEN, E. W, HOWLETT, K. F, ZAJAC, J. D, PROIETTO, J

“…To study the secondary consequences of impaired suppression of endogenous glucose production (EGP) we have created a transgenic rat overexpressing the…”
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The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived Genome by BROOK, Frances A, EVANS, Edward P, LORD, Christopher J, LYONS, Paul A, RAINBOW, Daniel B, HEWLETT, Sarah K, WICKER, Linda S, TODD, John A, GARDNER, Richard L

“…The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived Genome Frances A. Brook 1 , Edward P. Evans 1 , Christopher J. Lord 2 ,…”
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The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats by WADLEY, G. D, BRUCE, C. R, KONSTANTOPOULOS, N, MACAULAY, S. L, HOWLETT, K. F, HAWLEY, J. A, CAMERON-SMITH, D

“…Recruitment of the protein c-Cbl to the insulin receptor (IR) and its tyrosine phosphorylation via a pathway that is independent from phosphatidylinositol…”
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Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans by Howlett, K., Galbo, H., Lorentsen, J., Bergeron, R., Zimmerman‐Belsing, T., Bülow, J., Feldt‐Rasmussen, U., Kjær, M.

“…The role of adrenaline in regulating hepatic glucose production and muscle glucose uptake during exercise was examined in six adrenaline-deficient, bilaterally…”
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Adult phenotype in the mouse can be affected by epigenetic events in the early embryo by REIK, W, RÖMER, I, BARTON, S. C, SURANI, M. A, HOWLETT, S. K, KLOSE, J

“…Major epigenetic modifications apparently occur during early development in the mouse. The factors that induce such modifications are complex and may involve…”
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The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson's disease by Qarin, Shamma, Howlett, Sarah K, Jones, Joanne L, Barker, Roger A

“…Dopaminergic (DA) cell replacement therapies are a promising experimental treatment for Parkinson's disease (PD) and a number of different types of DA…”
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Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans by Watt, Matthew J., Howlett, Kirsten F., Febbraio, Mark A., Spriet, Lawrence L., Hargreaves, Mark

“…To evaluate the role of adrenaline in regulating carbohydrate metabolism during moderate exercise, 10 moderately trained men completed two 20 min exercise…”
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Sequence and regulation of morphological and molecular events during the first cell cycle of mouse embryogenesis by HOWLETT, S. K, BOLTON, V. N

“…Mouse oocytes were fertilized in vitro and the precise timing and sequence of morphological and molecular events occurring during the first cell cycle were…”
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