Search Results - "Howlett, Christopher"

Comprehensive gene expression profiling identifies distinct and overlapping transcriptional profiles in non-specific interstitial pneumonia and idiopathic pulmonary fibrosis by Cecchini, Matthew J, Hosein, Karishma, Howlett, Christopher J, Joseph, Mariamma, Mura, Marco

“…The clinical-radiographic distinction between idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP) is challenging. We sought to…”
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Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas by Papillon-Cavanagh, Simon, Lu, Chao, Gayden, Tenzin, Mikael, Leonie G, Bechet, Denise, Karamboulas, Christina, Ailles, Laurie, Karamchandani, Jason, Marchione, Dylan M, Garcia, Benjamin A, Weinreb, Ilan, Goldstein, David, Lewis, Peter W, Dancu, Octavia Maria, Dhaliwal, Sandeep, Stecho, William, Howlett, Christopher J, Mymryk, Joe S, Barrett, John W, Nichols, Anthony C, Allis, C David, Majewski, Jacek, Jabado, Nada

“…Nada Jabado, Jacek Majewski and colleagues identify mutations in multiple histone H3 genes causing recurrent p.Lys36Met alterations in head and neck squamous…”
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An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences by Ishak, Charles A., Marshall, Aren E., Passos, Daniel T., White, Carlee R., Kim, Seung J., Cecchini, Matthew J., Ferwati, Sara, MacDonald, William A., Howlett, Christopher J., Welch, Ian D., Rubin, Seth M., Mann, Mellissa R.W., Dick, Frederick A.

“…Repetitive genomic regions include tandem sequence repeats and interspersed repeats, such as endogenous retroviruses and LINE-1 elements. Repressive…”
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F4/80+Ly6Chigh Macrophages Lead to Cell Plasticity and Cancer Initiation in Colitis by Shin, Alice E., Tesfagiorgis, Yodit, Larsen, Frederikke, Derouet, Mathieu, Zeng, Peter Y.F., Good, Hayley J., Zhang, Liyue, Rubinstein, Mara R., Han, Yiping W., Kerfoot, Steven M., Nichols, Anthony C., Hayakawa, Yoku, Howlett, Christopher J., Wang, Timothy C., Asfaha, Samuel

“…Colorectal cancer is a leading cause of cancer death, and a major risk factor is chronic inflammation. Despite the link between colitis and cancer, the…”
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RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression by Marshall, Aren E., Roes, Michael V., Passos, Daniel T., DeWeerd, Megan C., Chaikovsky, Andrea C., Sage, Julien, Howlett, Christopher J., Dick, Frederick A.

“…Proliferative control in cancer cells is frequently disrupted by mutations in the retinoblastoma protein (RB) pathway. Intriguingly, RB1 mutations can arise…”
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Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition by Ruicci, Kara M., Plantinga, Paul, Pinto, Nicole, Khan, Mohammed I., Stecho, William, Dhaliwal, Sandeep S., Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Nichols, Anthony C.

“…Phosphoinositide 3‐kinase (PI3K) is aberrantly activated in head and neck squamous cell carcinomas (HNSCC) and plays a pivotal role in tumorigenesis by driving…”
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Clinical Next-Generation Sequencing Pipeline Outperforms a Combined Approach Using Sanger Sequencing and Multiplex Ligation-Dependent Probe Amplification in Targeted Gene Panel Analysis by Schenkel, Laila C, Kerkhof, Jennifer, Stuart, Alan, Reilly, Jack, Eng, Barry, Woodside, Crystal, Levstik, Alexander, Howlett, Christopher J, Rupar, Anthony C, Knoll, Joan H.M, Ainsworth, Peter, Waye, John S, Sadikovic, Bekim

“…Advances in next-generation sequencing (NGS) have facilitated parallel analysis of multiple genes enabling the implementation of cost-effective, rapid, and…”
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CAP-ACP Workload Model for Advanced Diagnostics in Precision Medicine by Park, Paul C, Kurek, Kyle C, DeCoteau, John, Howlett, Christopher J, Hawkins, Cynthia, Izevbaye, Iyare, Carter, Michael D, Redpath, Margaret, Lo, Bryan, Alex, Deepu, Yousef, George, Yip, Stephen, Maung, Raymond

“…Abstract Objectives In precision medicine, where oncologic management is tailored to the individual’s clinical and genetic profiles, advanced diagnostic…”
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TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma by Ruicci, Kara M, Meens, Jalna, Plantinga, Paul, Stecho, William, Pinto, Nicole, Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S, Barrett, John W, Howlett, Christopher J, Boutros, Paul C, Ailles, Laurie, Nichols, Anthony C

“…Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma…”
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The effect of HLA-DRB104:01 on a mouse model of atherosclerosis by Blackler, Garth, Akingbasote, James, Cairns, Ewa, Howlett, Christopher, Kiser, Patti, Barra, Lillian

“…HLA-DRB1 is associated with an increased risk of cardiovascular disease in patients with rheumatoid arthritis (RA). This study aimed to determine the effect of…”
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Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice by Fazio, Elena N, Young, Claire C, Toma, Jelena, Levy, Michael, Berger, Kurt R, Johnson, Charis L, Mehmood, Rashid, Swan, Patrick, Chu, Alphonse, Cregan, Sean P, Dilworth, F Jeffrey, Howlett, Christopher J, Pin, Christopher L

“…Pancreatitis is a debilitating disease of the exocrine pancreas that, under chronic conditions, is a major susceptibility factor for pancreatic ductal…”
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Dysregulated transforming growth factor-beta mediates early bone marrow dysfunction in diabetes by Kum, Jina J. Y., Howlett, Christopher J., Khan, Zia A.

“…Diabetes affects select organs such as the eyes, kidney, heart, and brain. Our recent studies show that diabetes also enhances adipogenesis in the bone marrow…”
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Molecular profiling of solid tumors by next-generation sequencing: an experience from a clinical laboratory by Bhai, Pratibha, Turowec, Jacob, Santos, Stephanie, Kerkhof, Jennifer, Pickard, LeeAnne, Foroutan, Aidin, Breadner, Daniel, Cecchini, Matthew, Levy, Michael A, Stuart, Alan, Welch, Stephen, Howlett, Christopher, Lin, Hanxin, Sadikovic, Bekim

“…Personalized targeted therapies have transformed management of several solid tumors. Timely and accurate detection of clinically relevant genetic variants in…”
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Low expression of NSD1, NSD2, and NSD3 define a subset of human papillomavirus-positive oral squamous carcinomas with unfavorable prognosis by Gameiro, Steven F, Ghasemi, Farhad, Zeng, Peter Y F, Mundi, Neil, Howlett, Christopher J, Plantinga, Paul, Barrett, John W, Nichols, Anthony C, Mymryk, Joe S

“…Frequent mutations in the nuclear receptor binding SET domain protein 1 (NSD1) gene have been observed in head and neck squamous cell carcinomas (HNSCC). NSD1…”
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Spleen tyrosine kinase expression is correlated with human papillomavirus in head and neck cancer by Black, Morgan, Ghasemi, Farhad, Sun, Ren X., Stecho, William, Datti, Alessandro, Meens, Jalna, Pinto, Nicole, Ruicci, Kara M., Khan, M. Imran, Han, Myung Woul, Shaikh, Mushfiq, Yoo, John, Fung, Kevin, MacNeil, Danielle, Palma, David A., Winquist, Eric, Howlett, Christopher J., Mymryk, Joe S., Ailles, Laurie, Boutros, Paul C., Barrett, John W., Nichols, Anthony C.

“…•High SYK expression is observed in HPV-positive HNSCC tumors.•Inhibition of SYK can control HNSCC cell line proliferation and migration.•SYK inhibition…”
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Immunohistochemical Detection of the Retinoblastoma Protein by Ishak, Charles A, Cecchini, Matthew J, Howlett, Christopher J, Dick, Frederick A

“…The retinoblastoma protein (pRB) plays a key role in proliferative control and genome stability. For these reasons its functions are considered to be tumor…”
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Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy by Cecchini, Matthew J., MD, PhD, Ishak, Charles A., BSc, Passos, Daniel T., DVM, PhD, Warner, Andrew, MSc, Palma, David A., MD, PhD, FRCPC, Howlett, Christopher J., MD, PhD, FRCPC, Driman, David K., MBChB, FRCPC, Dick, Frederick A., PhD

“…Summary The retinoblastoma tumor suppressor pathway is frequently inactivated in human cancer, enabling unrestrained proliferation. Most cancers, however,…”
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Erratum to: Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition by Ruicci, Kara M., Plantinga, Paul, Pinto, Nicole, Khan, Mohammed I., Stecho, William, Dhaliwal, Sandeep S., Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Nichols, Anthony C.

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Evaluation of HER2 immunohistochemistry expression in non-standard solid tumors from a Single-Institution Prospective Cohort by Verma, Saurav, Chapman, Amanda, Pickard, Lee-Anne, Porplycia, Danielle, McConkey, Haley, Jarosz, Patricia, Sinfield, James, Lauzon-Young, Carolyn, Cecchini, Matthew J, Howlett, Christopher, Grindrod, Natalie, Sadikovic, Bekim, Welch, Stephen A, Breadner, Daniel

“…Human epidermal growth factor receptor-2 (HER2) is a well-established prognostic and predictive biomarker. It is an FDA-approved therapeutic target for HER2…”
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Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification by Zeng, Peter Y.F., Cecchini, Matthew J., Barrett, John W., Shammas-Toma, Matthew, De Cecco, Loris, Serafini, Mara S., Cavalieri, Stefano, Licitra, Lisa, Hoebers, Frank, Brakenhoff, Ruud H., Leemans, C. René, Scheckenbach, Kathrin, Poli, Tito, Wang, Xiaowei, Liu, Xinyi, Laxague, Francisco, Prisman, Eitan, Poh, Catherine, Bose, Pinaki, Dort, Joseph C., Shaikh, Mushfiq H., Ryan, Sarah E.B., Dawson, Alice, Khan, Mohammed I., Howlett, Christopher J., Stecho, William, Plantinga, Paul, Daniela da Silva, Sabrina, Hier, Michael, Khan, Halema, MacNeil, Danielle, Mendez, Adrian, Yoo, John, Fung, Kevin, Lang, Pencilla, Winquist, Eric, Palma, David A., Ziai, Hedyeh, Amelio, Antonio L., Li, Shawn S-C., Boutros, Paul C., Mymryk, Joe S., Nichols, Anthony C.

“…There is significant interest in treatment de-escalation for human papillomavirus-associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients…”
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