Search Results - "Howie, R Nicole"

Direct Effects of Nicotine Exposure on Murine Calvaria and Calvarial Cells by Durham, Emily, Howie, R. Nicole, Warren, Graham, LaRue, Amanda, Cray, James

“…Despite the link between adverse birth outcomes due to pre- and peri-natal nicotine exposure, research suggests 11% of US women continue to smoke or use…”
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Optimizing bone wound healing using BMP2 with absorbable collagen sponge and Talymed nanofiber scaffold by Durham, Emily L, Howie, R Nicole, Hall, SarahRose, Larson, Nicholas, Oakes, Brayden, Houck, Reed, Grey, Zachary, Steed, Martin, LaRue, Amanda C, Muise-Helmericks, Robin, Cray, James

“…Bone is a highly vascularized and resilient organ with innate healing abilities, however some bone injuries overwhelm these attributes and require…”
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Pharmacological exposures may precipitate craniosynostosis through targeted stem cell depletion by Durham, Emily, Howie, R. Nicole, Larson, Nicholas, LaRue, Amanda, Cray, James

“…The Centers for Disease Control and Prevention, National Birth Defects Study suggests that environmental exposures including maternal thyroid diseases,…”
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A Model for Osteonecrosis of the Jaw with Zoledronate Treatment following Repeated Major Trauma by Howie, R Nicole, Borke, James L, Kurago, Zoya, Daoudi, Asma, Cray, James, Zakhary, Ibrahim E, Brown, Tara L, Raley, J Nathan, Tran, Loan T, Messer, Regina, Medani, Fardous, Elsalanty, Mohammed E

“…This study aims to develop a reproducible rat model for post-traumatic bisphosphonate-related osteonecrosis of the jaw (BRONJ). In our previous studies using…”
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Effects of In Utero Thyroxine Exposure on Murine Cranial Suture Growth by Howie, R Nicole, Durham, Emily L, Black, Laurel, Bennfors, Grace, Parsons, Trish E, Elsalanty, Mohammed E, Yu, Jack C, Weinberg, Seth M, Cray, Jr, James J

“…Large scale surveillance studies, case studies, as well as cohort studies have identified the influence of thyroid hormones on calvarial growth and…”
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Craniofacial Shape Variation in Twist1+/− Mutant Mice by Parsons, Trish E., Weinberg, Seth M., Khaksarfard, Kameron, Howie, R. Nicole, Elsalanty, Mohammed, Yu, Jack C., Cray, James J.

“…ABSTRACT Craniosynostosis (CS) is a relatively common birth defect resulting from the premature fusion of one or more cranial sutures. Human genetic studies…”
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Sfrp4 expression in thyroxine treated calvarial cells by Durham, Emily L., Grey, Zachary J., Black, Laurel, Howie, R. Nicole, Barth, Jeremy L., Lee, Beth S., Cray, James J.

“…Evidence suggests alterations of thyroid hormone levels can disrupt normal bone development. Most data suggest the major targets of thyroid hormones to be the…”
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Inkjet-based biopatterning of SDF-1β augments BMP-2-induced repair of critical size calvarial bone defects in mice by Herberg, Samuel, Kondrikova, Galina, Periyasamy-Thandavan, Sudharsan, Howie, R. Nicole, Elsalanty, Mohammed E, Weiss, Lee, Campbell, Phil, Hill, William D, Cray, James J

“…Abstract Background A major problem in craniofacial surgery is non-healing bone defects. Autologous reconstruction remains the standard of care for these…”
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Thyroxine Exposure Effects on the Cranial Base by Durham, Emily, Howie, R. Nicole, Parsons, Trish, Bennfors, Grace, Black, Laurel, Weinberg, Seth M., Elsalanty, Mohammed, Yu, Jack C., Cray, James J.

“…Thyroid hormone is important for skull bone growth, which primarily occurs at the cranial sutures and synchondroses. Thyroid hormones regulate metabolism and…”
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Involvement of calvarial stem cells in healing: A regional analysis of large cranial defects by Durham, Emily L, Howie, R Nicole, Houck, Reed, Oakes, Brayden, Grey, Zachary, Hall, SarahRose, Steed, Martin, LaRue, Amanda, Muise-Helmericks, Robin, Cray, James

“…Large craniofacial defects present a substantial clinical challenge that often requires the use of osteoconductive matrices and osteoinductive cues (i.e., bone…”
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Sub‐clinical dose of bone morphogenetic protein‐2 does not precipitate rampant, sustained inflammatory response in bone wound healing by Grey, Zachary J., Howie, R. Nicole, Durham, Emily L., Hall, Sarah Rose, Helke, Kristi L., Steed, Martin B., LaRue, Amanda C., Muise‐Helmericks, Robin C., Cray, James J.

“…Large bone injuries, defects, and chronic wounds present a major problem for medicine. Several therapeutic strategies are used clinically to precipitate bone…”
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Low-dose bone morphogenetic protein-2/stromal cell-derived factor-1β cotherapy induces bone regeneration in critical-size rat calvarial defects by Herberg, Samuel, Susin, Cristiano, Pelaez, Manuel, Howie, R Nicole, Moreno de Freitas, Rubens, Lee, Jaebum, Cray, Jr, James J, Johnson, Maribeth H, Elsalanty, Mohammed E, Hamrick, Mark W, Isales, Carlos M, Wikesjö, Ulf M E, Hill, William D

“…Increasing evidence suggests that stromal cell-derived factor-1 (SDF-1/CXCL12) is involved in bone formation, though underlying molecular mechanisms remain to…”
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Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model by Howie, R. Nicole, Herberg, Samuel, Durham, Emily, Grey, Zachary, Bennfors, Grace, Elsalanty, Mohammed, LaRue, Amanda C., Hill, William D., Cray, James J.

“…Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors…”
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Mesenchymal stem cell expression of SDF-1[beta] synergizes with BMP-2 to augment cell-mediated healing of critical-sized mouse calvarial defects by Herberg, Samuel, Aguilar-Perez, Alexandra, Howie, R Nicole, Kondrikova, Galina, Periyasamy-Thandavan, Sudharsan, Elsalanty, Mohammed E, Shi, Xingming, Hill, William D, Cray, James J

“…Bone has the potential for spontaneous healing. This process, however, often fails in patients with comorbidities. Tissue engineering combining functional…”
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Maternal environment and craniofacial growth: geometric morphometric analysis of mandibular shape changes with in utero thyroxine overexposure in mice by Kesterke, Matthew J., Judd, Margaret A., Mooney, Mark P., Siegel, Michael I., Elsalanty, Mohammed, Howie, R. Nicole, Weinberg, Seth M., Cray, James J.

“…An estimated 3% of US pregnancies are affected by maternal thyroid dysfunction, with between one and three of every 1000 pregnancies being complicated by…”
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Selective serotonin reuptake inhibitor exposure alters osteoblast gene expression and craniofacial development in mice by Cray, James J., Weinberg, Seth M., Parsons, Trish E., Howie, R. Nicole, Elsalanty, Mohammed, Yu, Jack C.

“…Background Selective serotonin reuptake inhibitor (SSRI) use in pregnancy has been linked to craniofacial birth defects. Little is known about the effects of…”
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Testing a novel nanofibre scaffold for utility in bone tissue regeneration by Howie, R. Nicole, Durham, Emily, Oakes, Brayden, Grey, Zachary, Smith, Jason, Campbell, Phil, LaRue, Amanda, Steed, Martin, Muise‐Helmericks, Robin, Cray, James

“…Many variables serve to alter the process of bone remodelling and diminish regeneration including the size and nature of the wound bed and health status of the…”
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Mesenchymal stem cell expression of SDF‐1β synergizes with BMP‐2 to augment cell‐mediated healing of critical‐sized mouse calvarial defects by Herberg, Samuel, Aguilar‐Perez, Alexandra, Howie, R. Nicole, Kondrikova, Galina, Periyasamy‐Thandavan, Sudharsan, Elsalanty, Mohammed E., Shi, Xingming, Hill, William D., Cray, James J.

“…Bone has the potential for spontaneous healing. This process, however, often fails in patients with comorbidities. Tissue engineering combining functional…”
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Removal of pamidronate from bone in rats using systemic and local chelation by Howie, R. Nicole, Bhattacharyya, Maryka, Salama, Mohamed E, Refaey, Mona El, Isales, Carlos, Borke, James, Daoudi, Asma, Medani, Fardous, Elsalanty, Mohammed E

“…Highlights • This study proved the feasibility of removing bisphosphonates from bone in-vivo. • Systemic agent reduced the bisphosphonate signal from the…”
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Effects of thyroxine exposure on the Twist 1 +/− phenotype: A test of gene-environment interaction modeling for craniosynostosis by Durham, Emily L., Howie, R. Nicole, Black, Laurel, Bennfors, Grace, Parsons, Trish E., Elsalanty, Mohammed, Yu, Jack C., Weinberg, Seth M., Cray Jr, James J.

“…Background Craniosynostosis, the premature fusion of one or more of the cranial sutures, is estimated to occur in 1:1800 to 2500 births. Genetic murine models…”
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