Search Results - "Howes, Oliver D"

Schizophrenia: an integrated sociodevelopmental-cognitive model by Howes, Oliver D, Dr, Murray, Robin M, Prof

“…Summary Schizophrenia remains a major burden on patients and society. The dopamine hypothesis attempts to explain the pathogenic mechanisms of the disorder,…”
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Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms by McCutcheon, Robert A., Abi-Dargham, Anissa, Howes, Oliver D.

“…The mesolimbic hypothesis has been a central dogma of schizophrenia for decades, positing that aberrant functioning of midbrain dopamine projections to limbic…”
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Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology by Kaar, Stephen J., Natesan, Sridhar, McCutcheon, Robert, Howes, Oliver D.

“…Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic disorders but are ineffective for some patients and associated with…”
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Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures by Osimo, Emanuele Felice, Beck, Katherine, Reis Marques, Tiago, Howes, Oliver D

“…Although synaptic loss is thought to be core to the pathophysiology of schizophrenia, the nature, consistency and magnitude of synaptic protein and mRNA…”
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Defining the Locus of Dopaminergic Dysfunction in Schizophrenia: A Meta-analysis and Test of the Mesolimbic Hypothesis by McCutcheon, Robert, Beck, Katherine, Jauhar, Sameer, Howes, Oliver D

“…Studies using positron emission tomography to image striatal dopamine function, have demonstrated that individuals with schizophrenia display increases in…”
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A neurobiological hypothesis for the classification of schizophrenia: type a (hyperdopaminergic) and type B (normodopaminergic) by Howes, Oliver D., Kapur, Shitij

“…Schizophrenia is usually classified based on clinical presentation. However, the conventional paranoid–disorganised–residual distinctions have had limited…”
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The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia by Howes, Oliver D, McCutcheon, Robert, Owen, Michael J, Murray, Robin M

“…Abstract The dopamine hypothesis is the longest standing pathoetiologic theory of schizophrenia. Because it was initially based on indirect evidence and…”
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Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls by Osimo, Emanuele F., Pillinger, Toby, Rodriguez, Irene Mateos, Khandaker, Golam M., Pariante, Carmine M., Howes, Oliver D.

“…•Patients with depression show reduced variability in pro-inflammatory immune measures.•Patients with depression show increases in pro-inflammatory immune…”
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Dopamine and glutamate in schizophrenia: biology, symptoms and treatment by McCutcheon, Robert  A., Krystal, John H., Howes, Oliver D.

“…Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both have been proposed to contribute significantly to the…”
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Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies by Kaar, Stephen J., Angelescu, Ilinca, Marques, Tiago Reis, Howes, Oliver D.

“…Parvalbumin interneurons are fast-spiking GABAergic neurons that provide inhibitory control of cortical and subcortical circuits and are thought to be a key…”
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Therapeutic Potential of TAAR1 Agonists in Schizophrenia: Evidence from Preclinical Models and Clinical Studies by Dedic, Nina, Dworak, Heather, Zeni, Courtney, Rutigliano, Grazia, Howes, Oliver D

“…Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target for neuropsychiatric disorders due to its ability to modulate…”
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Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness by Calcia, Marilia A., Bonsall, David R., Bloomfield, Peter S., Selvaraj, Sudhakar, Barichello, Tatiana, Howes, Oliver D.

“…Rationale Psychosocial stressors are a well-documented risk factor for mental illness. Neuroinflammation, in particular elevated microglial activity, has been…”
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Heterogeneity of Striatal Dopamine Function in Schizophrenia: Meta-analysis of Variance by Brugger, Stefan P., Angelescu, Ilinca, Abi-Dargham, Anissa, Mizrahi, Romina, Shahrezaei, Vahid, Howes, Oliver D.

“…It has been hypothesized that dopamine function in schizophrenia exhibits heterogeneity in excess of that seen in the general population. However, no previous…”
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Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study by Bloomfield, Peter S., Selvaraj, Sudhakar, Veronese, Mattia, Rizzo, Gaia, Bertoldo, Alessandra, Owen, David R., Bloomfield, Michael A.P., Bonoldi, Ilaria, Kalk, Nicola, Turkheimer, Federico, McGuire, Philip, de Paola, Vincenzo, Howes, Oliver D.

“…Objective:The purpose of this study was to determine whether microglial activity, measured using translocator-protein positron emission tomography (PET)…”
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The serotonin transporter in depression: Meta-analysis of in vivo and post mortem findings and implications for understanding and treating depression by Kambeitz, Joseph P, Howes, Oliver D

“…Abstract Background Altered serotonin transporter levels have been reported in blood and brain of patients with major depressive disorders. However, the…”
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Aberrant Salience, Information Processing, and Dopaminergic Signaling in People at Clinical High Risk for Psychosis by Howes, Oliver D., Hird, Emily J., Adams, Rick A., Corlett, Philip R., McGuire, Philip

“…The aberrant salience hypothesis proposes that striatal dopamine dysregulation causes misattribution of salience to irrelevant stimuli leading to psychosis…”
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Reappraising the variability of effects of antipsychotic medication in schizophrenia: a meta‐analysis by McCutcheon, Robert A., Pillinger, Toby, Efthimiou, Orestis, Maslej, Marta, Mulsant, Benoit H., Young, Allan H., Cipriani, Andrea, Howes, Oliver D.

“…It is common experience for practising psychiatrists that individuals with schizophrenia vary markedly in their symptomatic response to antipsychotic…”
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A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia by Jauhar, Sameer, Nour, Matthew M, Veronese, Mattia, Rogdaki, Maria, Bonoldi, Ilaria, Azis, Matilda, Turkheimer, Federico, McGuire, Philip, Young, Allan H, Howes, Oliver D

“…The dopamine hypothesis suggests that dopamine abnormalities underlie psychosis, irrespective of diagnosis, implicating dopamine dysregulation in bipolar…”
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Adherence to treatment guidelines in clinical practice: study of antipsychotic treatment prior to clozapine initiation by Howes, Oliver D., Vergunst, Francis, Gee, Siobhan, McGuire, Philip, Kapur, Shitij, Taylor, David

“…Clozapine is the only antipsychotic drug licensed for treatment-resistant schizophrenia but its use is often delayed. Since previous studies, national…”
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Dopaminergic basis of salience dysregulation in psychosis by Winton-Brown, Toby T, Fusar-Poli, Paolo, Ungless, Mark A, Howes, Oliver D

“…Highlights • Psychosis is typified by reality distortion and subcortical dopamine dysfunction. • The two may be linked through aberrant salience processing. •…”
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