Search Results - "Howes, Mark"

Endocytic crosstalk: cavins, caveolins, and caveolae regulate clathrin-independent endocytosis by Chaudhary, Natasha, Gomez, Guillermo A, Howes, Mark T, Lo, Harriet P, McMahon, Kerrie-Ann, Rae, James A, Schieber, Nicole L, Hill, Michelle M, Gaus, Katharina, Yap, Alpha S, Parton, Robert G

“…Several studies have suggested crosstalk between different clathrin-independent endocytic pathways. However, the molecular mechanisms and functional relevance…”
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Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers by Lakshminarayan, Ramya, Wunder, Christian, Becken, Ulrike, Howes, Mark T., Benzing, Carola, Arumugam, Senthil, Sales, Susanne, Ariotti, Nicholas, Chambon, Valérie, Lamaze, Christophe, Loew, Damarys, Shevchenko, Andrej, Gaus, Katharina, Parton, Robert G., Johannes, Ludger

“…Several cell surface molecules including signalling receptors are internalized by clathrin-independent endocytosis. How this process is initiated, how cargo…”
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Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis by Howes, Mark T, Mayor, Satyajit, Parton, Robert G

“…Eukaryotic cells deftly coordinate an array of endocytic pathways beyond the classical clathrin-mediated endocytic route. Although the existence of…”
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EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization by Morén, Björn, Shah, Claudio, Howes, Mark T, Schieber, Nicole L, McMahon, Harvey T, Parton, Robert G, Daumke, Oliver, Lundmark, Richard

“…Eps15 homology domain-containing 2 (EHD2) belongs to the EHD-containing protein family of dynamin-related ATPases involved in membrane remodeling in the…”
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Revisiting caveolin trafficking: the end of the caveosome by Parton, Robert G, Howes, Mark T

“…In this issue, a study by Hayer et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201003086) provides insights into the trafficking of caveolins, the major membrane…”
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Redistribution of caveolae during mitosis by Boucrot, Emmanuel, Howes, Mark T, Kirchhausen, Tomas, Parton, Robert G

“…Caveolae form a specialized platform within the plasma membrane that is crucial for an array of important biological functions, ranging from signaling to…”
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Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells by Howes, Mark T, Kirkham, Matthew, Riches, James, Cortese, Katia, Walser, Piers J, Simpson, Fiona, Hill, Michelle M, Jones, Alun, Lundmark, Richard, Lindsay, Margaret R, Hernandez-Deviez, Delia J, Hadzic, Gordana, McCluskey, Adam, Bashir, Rumasia, Liu, Libin, Pilch, Paul, McMahon, Harvey, Robinson, Phillip J, Hancock, John F, Mayor, Satyajit, Parton, Robert G

“…Although the importance of clathrin- and caveolin-independent endocytic pathways has recently emerged, key aspects of these routes remain unknown. Using…”
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The post-translational modification landscape of commercial beers by Kerr, Edward D., Caboche, Christopher H., Pegg, Cassandra L., Phung, Toan K., Gonzalez Viejo, Claudia, Fuentes, Sigfredo, Howes, Mark T., Howell, Kate, Schulz, Benjamin L.

“…Beer is one of the most popular beverages worldwide. As a product of variable agricultural ingredients and processes, beer has high molecular complexity. We…”
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The GTPase-Activating Protein GRAF1 Regulates the CLIC/GEEC Endocytic Pathway by Lundmark, Richard, Doherty, Gary J., Howes, Mark T., Cortese, Katia, Vallis, Yvonne, Parton, Robert G., McMahon, Harvey T.

“…Clathrin-independent endocytosis is an umbrella term for a variety of endocytic pathways that internalize numerous cargoes independently of the canonical coat…”
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Correction: Population Distribution Analyses Reveal a Hierarchy of Molecular Players Underlying Parallel Endocytic Pathways by Gupta, Gagan D, Dey, Gautam, Mg, Swetha, Ramalingam, Balaji, Shameer, Khader, Thottacherry, Joseph Jose, Kalappurakkal, Joseph Mathew, Howes, Mark T, Chandran, Ruma, Das, Anupam, Menon, Sindhu, Parton, Robert G, Sowdhamini, R, Thattai, Mukund, Mayor, Satyajit

“…[This corrects the article DOI: 10.1371/journal.pone.0100554.]…”
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Evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography by Lebastard, Matthieu, Le Boedec, Kevin, Howes, Mark, Joslyn, Stephen, Matheson, Jodi S., O'Brien, Robert T.

“…Background The origin of cough in dogs with heart murmurs is controversial, because the cough could be primary cardiac (eg, pulmonary edema, bronchi…”
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Response to letter regarding “Evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography” by Le Boedec, Kevin, Lebastard, Matthieu, Howes, Mark, Joslyn, Stephen, Matheson, Jodi S., O'Brien, Robert T.

“…Computed tomography also allowed us to assess this gradient relationship without the confounding effect of general anesthesia. Because the dogs were all awake,…”
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Cholesterol‐Sensitive Cdc42 Activation Regulates Actin Polymerization for Endocytosis via the GEEC Pathway by Chadda, Rahul, Howes, Mark T., Plowman, Sarah J., Hancock, John F., Parton, Robert G., Mayor, Satyajit

“…Glycosyl‐phosphatidylinositol (GPI)‐anchored proteins (GPI‐APs) are present at the surface of living cells in cholesterol dependent nanoscale clusters. These…”
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The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading by Doherty, Gary J, Åhlund, Monika K, Howes, Mark T, Morén, Björn, Parton, Robert G, McMahon, Harvey T, Lundmark, Richard

“…The rho GTPase-activating protein GTPase regulator associated with focal adhesion kinase-1 (GRAF1) remodels membranes into tubulovesicular clathrin-independent…”
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The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments by Cortese, Katia, Howes, Mark T, Lundmark, Richard, Tagliatti, Erica, Bagnato, Paola, Petrelli, Annalisa, Bono, Maria, McMahon, Harvey T, Parton, Robert G, Tacchetti, Carlo

“…The ErbB2 receptor is a clinically validated cancer target whose internalization and trafficking mechanisms remain poorly understood. HSP90 inhibitors, such as…”
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Population distribution analyses reveal a hierarchy of molecular players underlying parallel endocytic pathways by Gupta, Gagan D, Dey, Gautam, Swetha, M G, Ramalingam, Balaji, Shameer, Khader, Thottacherry, Joseph Jose, Kalappurakkal, Joseph Mathew, Howes, Mark T, Chandran, Ruma, Das, Anupam, Menon, Sindhu, Parton, Robert G, Sowdhamini, R, Thattai, Mukund, Mayor, Satyajit

“…Single-cell-resolved measurements reveal heterogeneous distributions of clathrin-dependent (CD) and -independent (CLIC/GEEC: CG) endocytic activity in…”
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Evolutionary analysis and molecular dissection of caveola biogenesis by Kirkham, Matthew, Nixon, Susan J, Howes, Mark T, Abi-Rached, Laurent, Wakeham, Diane E, Hanzal-Bayer, Michael, Ferguson, Charles, Hill, Michelle M, Fernandez-Rojo, Manuel, Brown, Deborah A, Hancock, John F, Brodsky, Frances M, Parton, Robert G

“…Caveolae are an abundant feature of mammalian cells. Integral membrane proteins called caveolins drive the formation of caveolae but the precise mechanisms…”
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Caveolin Regulates Endocytosis of the Muscle Repair Protein, Dysferlin by Hernández-Deviez, Delia J., Howes, Mark T., Laval, Steven H., Bushby, Kate, Hancock, John F., Parton, Robert G.

“…Dysferlin and Caveolin-3 are plasma membrane proteins associated with muscular dystrophy. Patients with mutations in the CAV3 gene show dysferlin…”
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Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis by McCluskey, Adam, Daniel, James A., Hadzic, Gordana, Chau, Ngoc, Clayton, Emma L., Mariana, Anna, Whiting, Ainslie, Gorgani, Nick N., Lloyd, Jonathan, Quan, Annie, Moshkanbaryans, Lia, Krishnan, Sai, Perera, Swetha, Chircop, Megan, von Kleist, Lisa, McGeachie, Andrew B., Howes, Mark T., Parton, Robert G., Campbell, Michael, Sakoff, Jennette A., Wang, Xuefeng, Sun, Jian‐Yuan, Robertson, Mark J., Deane, Fiona M., Nguyen, Tam H., Meunier, Frederic A., Cousin, Michael A., Robinson, Phillip J.

“…Dynamin is essential for clathrin‐mediated endocytosis (CME). We describe the Dyngo™ series of dynamin inhibitors with greatly improved potency, reduced…”
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SYSTEMIC BLASTOMYCOSIS IN A CAPTIVE RED RUFFED LEMUR (VARECIA RUBRA) by Rosser, Michael F, Lindemann, Dana M, Barger, Anne M, Allender, Matthew C, Hsiao, Shih-Hsuan, Howes, Mark E

“…A 5-yr-old, intact male red ruffed lemur (Varecia rubra) presented for evaluation as the result of a 1-wk history of lethargy and hyporexia. Physical…”
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