Search Results - "Howes, Harold L"

Novel anthelmintic agents. III. 1-(2-Arylvinyl)pyridinium salts by McFarland, James W, Howes, Harold L

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Anticoccidial derivatives of 6-azauracil. 1. Enhancement of activity by benzylation of nitrogen-1. Observations on the design of nucleotide analogs in chemotherapy by Mylari, Banavara L, Miller, Max W, Howes, Harold L, Figdor, Sanford K, Lynch, John E, Koch, Richard C

“…Benzylation of 6-azauracil at N-1 (which corresponds to the point of attachment of the ribose phosphate unit in pyrimidine nucleotides) has been found to…”
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Anticoccidial derivatives of 6-azauracil. 5. Potentiation by benzophenone side chains by Carroll, Ronnie D, Miller, Max W, Mylari, Banavara L, Chappel, Larry R, Howes, Harold L, Lynch, Martin J, Lynch, John E, Gupta, Shyam K, Rash, Jay J, Koch, Richard C

“…Attachment of p-benzophenone side chains at N1 was found to be one of the most effective modifications for enhancing the potency of 6-azauracil against a broad…”
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Anticoccidial derivatives of 6-azauracil. 2. High potency and long plasma life of N1-phenyl structures by Miller, Max W, Mylari, Banavara L, Howes, Harold L, Lynch, John E, Lynch, Martin J, Koch, Richard C

“…Attachment of substituted phenyl side chains at N1 of 6-azauracil caused striking increases in plasma life and anticoccidial potency. The increases were…”
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Anticoccidial derivatives of 6-azauracil. 4. A 1000-fold enhancement of potency by phenyl sulfide and phenyl sulfone side chains by Miller, Max W, Mylari, Banavara L, Howes, Harold L, Figdor, Sanford K, Lynch, Martin J, Lynch, John E, Gupta, Shyam K, Chappel, Larry R, Koch, Richard C

“…We report further progress in exploiting our earlier discovery that the anticoccidial activity of 6-azauracil increases markedly when appropriately substituted…”
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Anticoccidial derivatives of 6-azauracil. 3. Synthesis, high activity, and short plasma half-life of 1-phenyl-6-azauracils containing sulfonamide substituents by Miller, Max W, Mylari, Banavara L, Howes, Harold L, Figdor, Sanford K, Lynch, Martin J, Lynch, John E, Koch, Richard C

“…A series of 1-phenyl-6-azauracils containing sulfonamide substituents was prepared. In contrast to previous 1-phenyl-6-azauracils, some of these sulfonamides…”
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Novel anthelmintic agents. IV. Noncyclic amidines related to pyrantel by McFarland, James W, Howes, Harold L

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Alkylation of 2-methyl-5-nitroimidazole. Some potent antiprotozoal agents by Miller, Max Warren, Howes, Harold L, Kasubick, Robert V, English, Arthur R

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Novel anthelmintic agents. II. Pyrantel and other cyclic amidines by McFarland, James W, Conover, L. H, Howes, Harold L, Lynch, J. E, Chisholm, D. R, Austin, W. C, Cornwell, R. L, Danilewicz, J. C, Courtney, W, Morgan, D. H

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Novel anthelmintic agents. V. Thiazoline and dihydrothiazine analogs of pyrantel by McFarland, James W, Howes, Harold L, Conover, L. H, Lynch, J. E, Austin, William C, Morgan, D. H

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Anthelmintic Studies with Pyrantel. II. Prophylactic Activity in a Mouse-Ascaris suum Test Model by Howes, Harold L.

“…Mouse lung lesions were graded (0 to 5 according to severity) and the numbers of larvae per lung were determined at various time intervals after inoculation of…”
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Novel anthelmintic agents. 6. Pyrantel analogs with activity against whipworm by McFarland, James W, Howes, Horold L

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Anthelmintic Studies with Pyrantel. I. Therapeutic and Prophylactic Efficacy against the Enteral Stages of Various Helminths in Mice and Dogs by Howes, Harold L., Lynch, John E.

“…Pyrantel tartrate was evaluated as a therapeutic and prophylactic anthelmintic against intestinal parasites representing three nematode suborders (Strongylata,…”
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site of action of a broad-spectrum aryltriazine anticoccidial, CP-25,415 by Chappel, L.R, Howes, H.L, Lynch, J.E

“…CP-25,415 (2-[3-chloro-4-(4-chloro-benzoyl)]-phenyl-as-triazine-3,5(2H, 4H)-dione) is a potent member of a series of aryltriazine anticoccidials, which, at a…”
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