Search Results - "Howells, M"

Efficient generation of stable, heritable gene edits in wheat using CRISPR/Cas9 by Howells, Rhian M, Craze, Melanie, Bowden, Sarah, Wallington, Emma J

“…The use of CRISPR/Cas9 systems could prove to be a valuable tool in crop research, providing the ability to fully knockout gene function in complex genomes or…”
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Perspective of comprehensive and comprehensible multi-model energy and climate science in Europe by Nikas, A., Gambhir, A., Trutnevyte, E., Koasidis, K., Lund, H., Thellufsen, J.Z., Mayer, D., Zachmann, G., Miguel, L.J., Ferreras-Alonso, N., Sognnaes, I., Peters, G.P., Colombo, E., Howells, M., Hawkes, A., van den Broek, M., Van de Ven, D.J., Gonzalez-Eguino, M., Flamos, A., Doukas, H.

“…Europe’s capacity to explore the envisaged pathways that achieve its near- and long-term energy and climate objectives needs to be significantly enhanced. In…”
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The neurobiology of methamphetamine induced psychosis by Hsieh, Jennifer H, Stein, Dan J, Howells, Fleur M

“…Chronic methamphetamine abuse commonly leads to psychosis, with positive and cognitive symptoms that are similar to those of schizophrenia. Methamphetamine…”
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Maritime Spatial Planning on Land? Planning for Land-Sea Interaction Conflicts in the Danish Context by Howells, M., Ramírez-Monsalve, P.

“…Denmark is currently producing their first Maritime Spatial Plan, as required by the European Union's Maritime Spatial Planning Directive 2014/89. This article…”
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The role of stromal fibroblasts in lung carcinogenesis: A target for chemoprevention? by Mahale, Jagdish, Smagurauskaite, Gintare, Brown, Karen, Thomas, Anne, Howells, Lynne M.

“…The tumour microenvironment plays an essential role in the development and spread of cancers. Tumour cells interact with the surrounding extracellular matrix…”
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Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies by Haqq, Jonathan, Howells, Lynne M, Garcea, Giuseppe, Metcalfe, Matthew S, Steward, Will P, Dennison, Ashley R

“…Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a very poor prognosis. To date patient outcomes have not…”
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Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics by Howells, Lynne M, Berry, D P, Elliott, P J, Jacobson, E W, Hoffmann, E, Hegarty, B, Brown, K, Steward, W P, Gescher, A J

“…The phytochemical resveratrol has undergone extensive preclinical investigation for its putative cancer chemopreventive properties. Low systemic availability…”
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Improving the nutritional value of Golden Rice through increased pro-vitamin A content by Paine, J.A, Shipton, C.A, Chaggar, S, Howells, R.M, Kennedy, M.J, Vernon, G, Wright, S.Y, Hinchliffe, E, Adams, J.L, Silverstone, A.L

“…'Golden Rice' is a variety of rice engineered to produce β-carotene (pro-vitamin A) to help combat vitamin A deficiency, and it has been predicted that its…”
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Developing a community of practice around an open source energy modelling tool by Niet, T., Shivakumar, A., Gardumi, F., Usher, W., Williams, E., Howells, M.

“…Energy modelling is critical for addressing challenges such as integrating variable renewable energy and addressing climate impacts. This paper describes the…”
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Synergistic tonic and phasic activity of the locus coeruleus norepinephrine (LC-NE) arousal system is required for optimal attentional performance by Howells, Fleur M., Stein, Dan J., Russell, Vivienne A.

“…A certain level of arousal is required for an individual to perform optimally, and the locus coeruleus norepinephrine (LC-NE) system plays a central role in…”
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Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells by Alaqbi, Saif Sattar, Burke, Lynsey, Guterman, Inna, Green, Caleb, West, Kevin, Palacios-Gallego, Raquel, Cai, Hong, Alexandrou, Constantinos, Myint, Ni Ni Moe, Parrott, Emma, Howells, Lynne M, Higgins, Jennifer A, Jones, Donald J L, Singh, Rajinder, Britton, Robert G, Tufarelli, Cristina, Thomas, Anne, Rufini, Alessandro

“…Research into the metabolism of the non-essential amino acid (NEAA) proline in cancer has gained traction in recent years. The last step in the proline…”
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A PSTOL-like gene, TaPSTOL, controls a number of agronomically important traits in wheat by Milner, Matthew J, Howells, Rhian M, Craze, Melanie, Bowden, Sarah, Graham, Neil, Wallington, Emma J

“…Phosphorus (P) is an essential macronutrient for plant growth, and is required in large quantities by elite varieties of crops to maintain yields…”
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Interactions among Three Distinct CesA Proteins Essential for Cellulose Synthesis by Taylor, Neil G., Howells, Rhian M., Huttly, Alison K., Vickers, Kate, Turner, Simon R.

“…In a screen to identify novel cellulose deficient mutants, three lines were shown to be allelic and define a novel complementation group, irregular xylem5…”
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Effects of Intraspecific Genetic Variation and Prior Herbivory in an Old-Field Plant on the Abundance of the Specialist Aphid Uroleucon nigrotuberculatum (Hemiptera: Aphididae) by Williams, Ray S, Howells, Jessica M

“…Intraspecific genetic variation in plants can contribute to the diversity and abundance of associated insects, though many questions remain about why some…”
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New Paradigms to Assess Consequences of Long-Term, Low-Dose Curcumin Exposure in Lung Cancer Cells by Smagurauskaite, Gintare, Mahale, Jagdish, Brown, Karen, Thomas, Anne L, Howells, Lynne M

“…Curcumin has been investigated extensively for cancer prevention, but it has been proposed that long-term treatments may promote clonal evolution and gain of…”
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Assessing the role of low-emission hydrogen: A techno-economic database for hydrogen pathways modelling by Plazas-Niño, F.A., Yeganyan, R., Cannone, C., Howells, M., Borba, B., Quirós-Tortós, J.

“…Hydrogen is globally acknowledged as a versatile energy carrier crucial for decarbonization in multiple sectors. Many countries have initiated the development…”
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Cost minimization for fully renewable electricity systems: A Mauritius case study by Timmons, D., Dhunny, A.Z., Elahee, K., Havumaki, B., Howells, M., Khoodaruth, A., Lema-Driscoll, A.K., Lollchund, M.R., Ramgolam, Y.K., Rughooputh, S.D.D.V., Surroop, D.

“…Climate change is the world's most prominent environmental problem, and fossil-fuel combustion is its primary cause. To set carbon reduction goals, policy…”
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Technoeconomic data and assumptions for long-term energy systems modelling in Indonesia by Hersaputri, L.D., Yeganyan, R., Cannone, C., Plazas-Niño, F.A., Osei-Owusu, S., Kountouris, Y., Howells, M.

“…Indonesia's emission reduction commitment and clean energy transition target emphasises the importance of energy system modelling for analysing and projecting…”
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Techno-economic data and assumptions for open energy modelling of decarbonisation pathways in the Philippines by Dixon, L., Yeganyan, R., Cannone, C., Howells, M., Foster, V., Plazas-Niño, F.A.

“…This article introduces an openly accessible dataset aimed at supporting energy system modelling of decarbonisation pathways in the Philippines. The dataset…”
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Informing sustainable energy policy in developing countries: An assessment of decarbonization pathways in Colombia using open energy system optimization modelling by Plazas-Niño, F.A., Yeganyan, R., Cannone, C., Howells, M., Quirós-Tortós, J.

“…Colombia is committed to reducing its greenhouse gas (GHG) emissions by 51 % by 2030 as part of the Paris Agreement, with a further goal of achieving carbon…”
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