Search Results - "Howells, L M"

Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP) by Howells, L.M., Chalmers, J.R., Gran, S., Ahmed, A., Apfelbacher, C., Burton, T., Howie, L., Lawton, S., Ridd, M.J., Rogers, N.K., Sears, A.V., Spuls, P., Kobyletzki, L., Thomas, K.S.

“…Summary Background Eczema control has been identified as an important outcome by key stakeholders in eczema research (including patients, carers, healthcare…”
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Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity by JONES, D. J. L, LAMB, J. H, VERSCHOYLE, R. D, HOWELLS, L. M, BUTTERWORTH, M, LIM, C. K, FERRY, D, FARMER, P. B, GESCHER, A. J

“…Quercetin (3,5,7,3',4'-pentahydroxyflavone) is a flavone with putative ability to prevent cancer and cardiovascular diseases. Its metabolism was evaluated in…”
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Differences between human breast cell lines in susceptibility towards growth inhibition by genistein by DAMPIER, K, HUDSON, E. A, HOWELLS, L. M, MANSON, M. M, WALKER, R. A, GESCHER, A

“…Genistein is thought to contribute to the putative breast cancer preventive activity of soya. The mechanisms by which it arrests the growth of breast cells are…”
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Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment by Moiseeva, E P, Fox, L H, Howells, L M, Temple, L A F, Manson, M M

“…Indole-3-carbinol (I3C) is a promising anticancer dietary compound, which inhibits breast cancer in animal models. The objective of the current study was to…”
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Determining the efficacy of dietary phytochemicals in cancer prevention by Manson, M M, Foreman, B E, Howells, L M, Moiseeva, E P

“…Accumulating data suggest that dietary phytochemicals have the potential to moderate deregulated signalling or reinstate checkpoint pathways and apoptosis in…”
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Modulation of signal-transduction pathways by chemopreventive agents by Manson, M M, Holloway, K A, Howells, L M, Hudson, E A, Plummer, S M, Squires, M S, Prigent, S A

“…For a disease such as cancer, where a number of alterations to normal cell function accumulate over time, there are several opportunities to inhibit, slow down…”
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Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics by Howells, Lynne M, Berry, D P, Elliott, P J, Jacobson, E W, Hoffmann, E, Hegarty, B, Brown, K, Steward, W P, Gescher, A J

“…The phytochemical resveratrol has undergone extensive preclinical investigation for its putative cancer chemopreventive properties. Low systemic availability…”
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Prospects for plant-derived chemopreventive agents exhibiting multiple mechanisms of action by Howells, L M, Manson, M M

“…There is great potential for the use of plant-derived agents in the fight to prevent onset or delay progression of the carcinogenic process. Epidemiological…”
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Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line by Howells, Lynne M, Gallacher-Horley, Barbara, Houghton, Catherine E, Manson, Margaret M, Hudson, E Ann

“…We have identified a new target for the chemopreventive dietary agent indole-3-carbinol (13C) in the antiapoptotic signaling pathway involving…”
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Inhibition of Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Is Not Sufficient to Account for Indole-3-Carbinol–Induced Apoptosis in Some Breast and Prostate Tumor Cells by Howells, Lynne M, Hudson, E Ann, Manson, Margaret M

“…Purpose and Experimental Design: Indole-3-carbinol has been proposed to induce apoptosis via a mechanism involving inhibition of protein kinase B (PKB)…”
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Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line by Hudson, E Ann, Howells, Lynne M, Gallacher-Horley, Barbara, Fox, Louise H, Gescher, Andreas, Manson, Margaret M

“…Many tumours undergo disregulation of polyamine homeostasis and upregulation of ornithine decarboxylase (ODC) activity, which can promote carcinogenesis. In…”
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