Search Results - "Howell, R. W."

MIRD Pamphlet No. 16: Techniques for Quantitative Radiopharmaceutical Biodistribution Data Acquisition and Analysis for Use in Human Radiation Dose Estimates by Siegel, Jeffry A, Thomas, Stephen R, Stubbs, James B, Stabin, Michael G, Hays, Marguerite T, Koral, Kenneth F, Robertson, James S, Howell, Roger W, Wessels, Barry W, Fisher, Darrell R, Weber, David A, Brill, A. Bertrand

“…This report describes recommended techniques for radiopharmaceutical biodistribution data acquisition and analysis in human subjects to estimate radiation…”
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Free Radical-Initiated and Gap Junction-Mediated Bystander Effect due to Nonuniform Distribution of Incorporated Radioactivity in a Three-Dimensional Tissue Culture Model by Bishayee, Anupam, Hill, Helene Z., Stein, Dana, Rao, Dandamudi V., Howell, Roger W.

“…Bishayee, A., Hill, H. Z., Stein, D., Rao, D. V. and Howell, R. W. Free Radical-Initiated and Gap Junction-Mediated Bystander Effect due to Nonuniform…”
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Radiation spectra for Auger-electron emitting radionuclides: report No. 2 of AAPM Nuclear Medicine Task Group No. 6 by Howell, R W

“…Radiation spectra for radionuclides currently provided by the MIRD Committee and ICRP do not include the very low-energy N- and O-shell Auger electrons. These…”
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Evidence for Pronounced Bystander Effects Caused by Nonuniform Distributions of Radioactivity using a Novel Three-Dimensional Tissue Culture Model by Bishayee, Anupam, Rao, Dandamudi V., Howell, Roger W.

“…A new in vitro multicellular cluster model has been developed to assess the impact of nonuniform distributions of radioactivity on the biological response of…”
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Cellular Dosimetry: Absorbed Fractions for Monoenergetic Electron and Alpha Particle Sources and S-Values for Radionuclides Uniformly Distributed in Different Cell Compartments by Goddu, S. Murty, Howell, Roger W, Rao, Dandamudi V

“…The importance of cellular dosimetry in both diagnostic and therapeutic nuclear medicine is becoming increasingly recognized. Experimental range-energy…”
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S Values for Radionuclides Localized Within the Skeleton by Bouchet, Lionel G, Bolch, Wesley E, Howell, Roger W, Rao, Dandamudi V

“…Calculations of radiation absorbed dose to the active marrow are important to radionuclide therapies such as radioimmunotherapy and bone pain palliation. In…”
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The impact of scallop dredging on rocky-reef substrata by Boulcott, Philip, Howell, Trevor R.W.

“…A quadrat image from the towed path across a rocky-reef in the Sound of Jura showing: (a) damage to the elephant hide sponge, Pachymatisma johnstonia, and (b)…”
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Multicellular Dosimetry for Micrometastases: Dependence of Self-Dose Versus Cross-Dose to Cell Nuclei on Type and Energy of Radiation and Subcellular Distribution of Radionuclides by Goddu, S. Murty, Rao, Dandamudi V, Howell, Roger W

“…In radioimmunotherapy, the treatment of bulk tumors by radionuclides that emit energetic beta particles is the preferred approach. However, for the eradication…”
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Protection by DMSO against Cell Death Caused by Intracellularly Localized Iodine-125, Iodine-131 and Polonium-210 by Bishayee, Anupam, Rao, Dandamudi V., Bouchet, Lionel G., Bolch, Wesley E., Howell, Roger W.

“…Bishayee, A., Rao, D. V., Bouchet, L. G., Bolch, W. E. and Howell, R. W. Protection by DMSO against Cell Death Caused by Intracellularly Localized Iodine-125,…”
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Meeting overview by Howell, R. W., Martin, R. F., Nikjoo, H., Pomplun, E., Terrissol, M., Watanable, R., Yasui, L., Kassis, Amin I., Adelstein, S. James

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The MIRD Schema: from organ to cellular dimensions by Howell, R W

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[125I/127I]IodoHoechst 33342:  Synthesis, DNA Binding, and Biodistribution by Harapanhalli, Ravi S, McLaughlin, Larry W, Howell, Roger W, Rao, Dandamudi V, Adelstein, S. James, Kassis, Amin I

“…An iodinated analog of the DNA-minor-groove-binding agent Hoechst 33342 has been synthesized and evaluated for DNA binding and tumor targeting. The…”
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The Question of Relative Biological Effectiveness and Quality Factor for Auger Emitters Incorporated into Proliferating Mammalian Cells by Howell, Roger W., Rao, Dandamudi V., Hou, De-Yan, Narra, Venkat R., Kandula S. R. Sastry

“…The problem of determining RBE values for Auger emitters incorporated into proliferating mammalian cells is examined. In general, the reference radiation plays…”
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Bystander responses in three-dimensional cultures containing radiolabelled and unlabelled human cells by Pinto, M., Azzam, E. I., Howell, R. W.

“…Research on the radiation-induced bystander effect has been carried out mainly in 2-D tissue culture systems. This study uses a 3-D model, wherein apparently…”
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On the Equivalent Dose for Auger Electron Emitters by Howell, Roger W., Narra, Venkat R., Kandula S. R. Sastry, Rao, Dandamudi V.

“…Radionuclides that emit Auger electrons are widely used in nuclear medicine (e.g., ^{99{\rm m}}{\rm Tc},\ {}^{123}{\rm I},\ {}^{201}{\rm Tl}$) and biomedical…”
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Application of the Linear-Quadratic Model to Radioimmunotherapy: Further Support for the Advantage of Longer-Lived Radionuclides by Howell, Roger W, Goddu, S. Murty, Rao, Dandamudi V

“…Radioimmunotherapy (RIT), as it is currently practiced, delivers low doses to tumors primarily because of dose-limiting bone marrow toxicity. The biologic…”
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Radiotoxicity of Platinum-195m-Labeled trans-Platinum (II) in Mammalian Cells by Howell, Roger W., Kassis, Amin I., Adelstein, S. James, Rao, Dandamudi V., Wright, Harvel A., Hamm, Robert N., Turner, James E., Kandula S. R. Sastry

“…The chemotoxicity and radiotoxicity of trans-dichlorodiammineplatinum (II) labeled with ^{195{\rm m}}{\rm Pt}$ ($trans\text{-}{}^{195{\rm m}}{\rm Pt}$) are…”
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Vitamins as Radioprotectors In Vivo II. Protection by Vitamin A and Soybean Oil against Radiation Damage Caused by Internal Radionuclides by Harapanhalli, Ravi S., Narra, Venkat R., Yaghmai, Vahid, Azure, Michael T., Goddu, S. Murty, Howell, Roger W., Rao, Dandamudi V.

“…Tissue-incorporated radionuclides impart radiation energy over extended periods of time depending on their effective half-lives. The capacity of vitamin A…”
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Relative Biological Effectiveness of Alpha-Particle Emitters In Vivo at Low Doses by Howell, Roger W., Azure, Michael T., Narra, Venkat R., Rao, Dandamudi V.

“…The therapeutic potential of radionuclides that emit α particles, as well as their associated health hazards, have attracted considerable attention. The…”
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Radiotoxicity of Gadolinium-148 and Radium-223 in Mouse Testes: Relative Biological Effectiveness of Alpha-Particle Emitters In Vivo by Howell, Roger W., Goddu, S. Murty, Narra, Venkat R., Fisher, Darrell R., Schenter, Robert E., Rao, Dandamudi V.

“…The biological effects of radionuclides that emit α particles are of considerable interest in view of their potential for therapy and their presence in the…”
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