Search Results - "Howell, P. Lynne"

Biofilm Exopolysaccharides of Pathogenic Fungi: Lessons from Bacteria by Sheppard, Donald C., Howell, P. Lynne

“…Exopolysaccharides play an important structural and functional role in the development and maintenance of microbial biofilms. Although the majority of research…”
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The molecular mechanism of the type IVa pilus motors by McCallum, Matthew, Tammam, Stephanie, Khan, Ahmad, Burrows, Lori L., Howell, P. Lynne

“…Type IVa pili are protein filaments essential for virulence in many bacterial pathogens; they extend and retract from the surface of bacterial cells to pull…”
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Gram-negative synthase-dependent exopolysaccharide biosynthetic machines by Low, Kristin E, Howell, P Lynne

“…Bacteria predominantly exist as matrix embedded communities of cells called biofilms. The biofilm matrix is made up of a variety of self-produced extracellular…”
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Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl by Franklin, Michael J, Nivens, David E, Weadge, Joel T, Howell, P Lynne

“…Pseudomonas aeruginosa thrives in many aqueous environments and is an opportunistic pathogen that can cause both acute and chronic infections. Environmental…”
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Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix by Jennings, Laura K, Storek, Kelly M, Ledvina, Hannah E, Coulon, Charlène, Marmont, Lindsey S, Sadovskaya, Irina, Secor, Patrick R, Tseng, Boo Shan, Scian, Michele, Filloux, Alain, Wozniak, Daniel J, Howell, P Lynne, Parsek, Matthew R

“…Biofilm formation is a complex, ordered process. In the opportunistic pathogen Pseudomonas aeruginosa, Psl and Pel exopolysaccharides and extracellular DNA…”
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phage λ major tail protein structure reveals a common evolution for long-tailed phages and the type VI bacterial secretion system by Pell, Lisa G, Kanelis, Voula, Donaldson, Logan W, Lynne Howell, P, Davidson, Alan R

“…Most bacteriophages possess long tails, which serve as the conduit for genome delivery. We report the solution structure of the N-terminal domain of gpV, the…”
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Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange by Hmelo, Laura R, Borlee, Bradley R, Almblad, Henrik, Love, Michelle E, Randall, Trevor E, Tseng, Boo Shan, Lin, Chuyang, Irie, Yasuhiko, Storek, Kelly M, Yang, Jaeun Jane, Siehnel, Richard J, Howell, P Lynne, Singh, Pradeep K, Tolker-Nielsen, Tim, Parsek, Matthew R, Schweizer, Herbert P, Harrison, Joe J

“…Here, the authors describe genetically engineering the Pseudomonas genome by two-step allelic exchange. Suicide vector-encoded alleles are used to generate…”
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Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases by Le Mauff, François, Bamford, Natalie C., Alnabelseya, Noor, Zhang, Yongzhen, Baker, Perrin, Robinson, Howard, Codée, Jeroen D.C., Howell, P. Lynne, Sheppard, Donald C.

“…During infection, the fungal pathogen Aspergillus fumigatus forms biofilms that enhance its resistance to antimicrobials and host defenses. An integral…”
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Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity by Pestrak, Matthew J, Baker, Perrin, Dellos-Nolan, Sheri, Hill, Preston J, Passos da Silva, Daniel, Silver, Holly, Lacdao, Ira, Raju, Deepa, Parsek, Matthew R, Wozniak, Daniel J, Howell, P Lynne

“…is an opportunistic, nosocomial bacterial pathogen that forms persistent infections due to the formation of protective communities, known as biofilms. Once the…”
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The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix by Colvin, Kelly M., Irie, Yasuhiko, Tart, Catherine S., Urbano, Rodolfo, Whitney, John C., Ryder, Cynthia, Howell, P. Lynne, Wozniak, Daniel J., Parsek, Matthew R.

“…Summary Extracellular polysaccharides comprise a major component of the biofilm matrix. Many species that are adept at biofilm formation have the capacity to…”
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Deacetylated microbial biofilm exopolysaccharides: It pays to be positive by Ostapska, Hanna, Howell, P Lynne, Sheppard, Donald C

“…About the Authors: Hanna Ostapska Affiliations Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada, Infectious Diseases in…”
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A systematic pipeline for classifying bacterial operons reveals the evolutionary landscape of biofilm machineries by Bundalovic-Torma, Cedoljub, Whitfield, Gregory B, Marmont, Lindsey S, Howell, P Lynne, Parkinson, John

“…In bacteria functionally related genes comprising metabolic pathways and protein complexes are frequently encoded in operons and are widely conserved across…”
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The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing by Pfoh, Roland, Subramanian, Adithya S, Huang, Jingjing, Little, Dustin J, Forman, Adam, DiFrancesco, Benjamin R, Balouchestani-Asli, Negar, Kitova, Elena N, Klassen, John S, Pomès, Régis, Nitz, Mark, Howell, P. Lynne

“…The synthesis of exopolysaccharides as biofilm matrix components by pathogens is a crucial factor for chronic infections and antibiotic resistance. Many…”
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Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation by Bamford, Natalie C., Le Mauff, François, Van Loon, Jaime C., Ostapska, Hanna, Snarr, Brendan D., Zhang, Yongzhen, Kitova, Elena N., Klassen, John S., Codée, Jeroen D. C., Sheppard, Donald C., Howell, P. Lynne

“…The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus . Deletion of a gene encoding a…”
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PilY1 regulates the dynamic architecture of the type IV pilus machine in Pseudomonas aeruginosa by Guo, Shuaiqi, Chang, Yunjie, Brun, Yves V., Howell, P. Lynne, Burrows, Lori L., Liu, Jun

“…Type IV pili (T4P) produced by the pathogen Pseudomonas aeruginosa play a pivotal role in adhesion, surface motility, biofilm formation, and infection in…”
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Structural basis for the O-acetyltransferase function of the extracytoplasmic domain of OatA from Staphylococcus aureus by Jones, Carys S., Sychantha, David, Howell, P. Lynne, Clarke, Anthony J.

“…Many bacteria possess enzymes that modify the essential cell-wall polymer peptidoglycan by O-acetylation. This modification occurs in numerous Gram-positive…”
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Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity by Snarr, Brendan D., Baker, Perrin, Bamford, Natalie C., Sato, Yukiko, Liu, Hong, Lehoux, Mélanie, Gravelat, Fabrice N., Ostapska, Hanna, Baistrocchi, Shane R., Cerone, Robert P., Filler, Elan E., Parsek, Matthew R., Filler, Scott G., Howell, P. Lynne, Sheppard, Donald C.

“…Galactosaminogalactan and Pel are cationic heteropolysaccharides produced by the opportunistic pathogens Aspergillus fumigatus and Pseudomonas aeruginosa,…”
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PelA Deacetylase Activity Is Required for Pel Polysaccharide Synthesis in Pseudomonas aeruginosa by Colvin, Kelly M, Alnabelseya, Noor, Baker, Perrin, Whitney, John C, Howell, P. Lynne, Parsek, Matthew R

“…The Pel polysaccharide serves as an intercellular adhesin for the formation and maintenance of biofilms in the opportunistic pathogen Pseudomonas aeruginosa…”
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Bps polysaccharide of Bordetella pertussis resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts Escherichia coli into a respiratory pathogen by Fullen, Audra R, Gutierrez-Ferman, Jessica L, Yount, Kacy S, Love, Cheraton F, Choi, Hyun G, Vargas, Mario A, Raju, Deepa, Corps, Kara N, Howell, P Lynne, Dubey, Purnima, Deora, Rajendar

“…Infections and disease caused by the obligate human pathogen Bordetella pertussis (Bp) are increasing, despite widespread vaccinations. The current acellular…”
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PelA and PelB proteins form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation in Pseudomonas aeruginosa by Marmont, Lindsey S., Whitfield, Gregory B., Rich, Jacquelyn D., Yip, Patrick, Giesbrecht, Laura B., Stremick, Carol A., Whitney, John C., Parsek, Matthew R., Harrison, Joe J., Howell, P. Lynne

“…The pellicle (PEL) polysaccharide is synthesized by the opportunistic pathogen Pseudomonas aeruginosa and is an important biofilm constituent critical for…”
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