Search Results - "Howell, M.D."

Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment by Howell, M.D, Gottschall, P.E

“…Highlights ► Chondroitin sulfate proteoglycans in the brain matrix regulate neural plasticity. ► Extracellular metalloproteinases alter structural and synaptic…”
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p21 Deficiency Increases Susceptibility of Developing Eczema Vaccinatum: Implications for Atopic Dermatitis by Leung, D.Y.M, Lesley, L.J, Streib, J.E, Dunlap, A, Howell, M.D

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Tumor Necrosis Factor (TNF)-alpha Down-Regulates Loricrin and Involucrin by Kim, B.E, Leung, D.Y.M, Boguniewicz, M, Howell, M.D

“…[...]the psoriasis skin is characterized by Th1 cytokines. [...]we investigated filaggrin and loricrin expression in psoriasis skin and whether Th1 cytokines…”
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097 Novel Genomic Signature Predicts Response to Ruxolitinib Cream in Psoriasis by Liu, H., Howell, M.D.

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004 Ruxolitinib Cream Suppresses Inflammation in Adult Mild to Moderate Psoriasis Patients by Howell, M.D., Liu, H.

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Atopic Dermatitis Associated with Eczema Herpeticum is Associated with Abnormal Expression of Keratin Genes in Skin Biopsies by Grigoryev, D.N, Howell, M.D, Watkins, T.N, Cheadle, C, Boguniewicz, M, Barnes, K.C, Leung, D.Y

“…Gene expression profiles of sham-treated and VV-treated unaffected skin explants from ADEH+ (n=5), ADEH- (n=11), or NA (n=13) individuals were generated using…”
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TNF-alpha Down-Regulates Filaggrin and Loricrin Through c-Jun N-Terminal Kinase: Role for TNF Antagonists to Improve Skin Barrier by Kim, B.E, Howell, M.D, Guttman, E, Gilleaudeau, P, Cardinale, I, Boguniewicz, M, Krueger, J.G, Leung, D.Y

“…Psoriasis is characterized by over-expression of TNF-alpha and impaired skin barrier. [...]we investigated whether skin barrier proteins are modulated by…”
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Specificity Protein 1 is Pivotal in Keratinocyte Response against Vaccinia Virus: Potential Implications for Eczema Vaccinatum by Bin, L, Kim, B.E, Howell, M.D, Leung, D.Y. M

“…Previous studies have shown that the transcription factor, specificity protein 1 (Sp1), is recruited to the cytoplasmic VV replication process. [...]we…”
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Immunomodulatory Effect of Rapamycin on Innate Immune Response Genes by Howell, M.D, Kim, B.E, Leung, D.Y

“…Previous studies have shown that treatment with topical calcineurin inhibitors and corticosteroids reduce Staphylococcus aureus colonization on AD skin…”
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IL-4 and IL-13 Induction of SOCS-3 Negatively Regulates TNF-α and IFN-γ Induced Human β Defensin (HBD)-3 Expression in Keratinocytes by Fairchild, H.R, Leung, D.Y.M, Howell, M.D

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Increased Risk of Eczema Vaccinatum in Atopic Dermatitis Patients with a History of Herpetic Infections by Howell, M.D, Lesley, L.J, Kim, B.E, Streib, J.E, Taylor, P, Zaccaro, D, Boguniewicz, M, Leung, D.Y.M

“…Atopic dermatitis (AD) is characterized by an impaired innate immune response, that contributes to recurrent skin infections…”
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Inhibition of S100A11 Gene Expression Impairs Keratinocyte Response against Vaccinia Virus: Implications for Eczema Vaccinatum by Bin, L.H, Howell, M.D, Streib, J.E, Leung, D.Y

“…AD patients are predisposed to disseminated vaccinia viral (VV) skin infection after smallpox vaccination. [...]we investigated whether inhibiting expression…”
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Identification of Differences in the Molecular Response to Vaccinia Virus in Atopic Dermatitis and Psoriasis Skin by Grigoryev, D.N, Howell, M.D, Watkins, T, Chen, Y, Cheadle, C, Boguniewicz, M, Barnes, K.C, Leung, D.Y

“…Gene expression profiles of sham-treated and VV-treated unaffected skin explants from AD (n = 12), psoriatic (n = 12), or healthy (n = 13) individuals were…”
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Loricrin and Involucrin Expression is Down-Regulated by Th2 Cytokines through STAT-6 by Kim, B.E, Leung, D.Y.M, Boguniewicz, M, Howell, M.D

“…Loricrin (LOR) and involucrin (IVL) are important proteins involved in epidermal differentiation. [...]this study evaluated the expression of LOR and IVL in AD…”
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Modulation of Filaggrin by Th2 Cytokines in the Skin of Atopic Dermatitis (AD) by Howell, M.D, Kim, B.E, Boguniewicz, M, Leung, D.Y.M

“…Filaggrin gene and protein expression was measured in skin biopsies and cultured keratinocytes using real-time RT-PCR and immunohistochemistry…”
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853 A novel expression based, non-invasive method to differentiate atopic dermatitis and psoriasis by Ratnappan, R., Whitaker, J., Allen, T., Rock, J., Howell, M.D.

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Ceragenins: A New Class of Anti-Vaccinia Viral Compounds by Howell, M.D, Geng, D, Streib, J.E, Savage, P.B, Leung, D.Y.M

“…Rationale Eczema vaccinatum (EV) is a potentially fatal adverse reaction that occurs in individuals with atopic dermatitis (AD) due to disseminated viral skin…”
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Th2 Cytokines Act on S100/A11 to Down-regulate Keratinocyte Differentiation: Implications for Atopic Dermatitis by Leung, D.Y.M, Fairchild, H.R, Boguniewicz, M, Redzic, J.S, Hansen, K.C, Howell, M.D

“…Conclusions This study suggests that Th2-mediated reduction in S100/A11 plays a key role in contributing to skin barrier dysfunction and impaired innate immune…”
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A Murine Model of Eczema Vaccinatum by Elkhal, A, Scott, J, MacArthur, D.H, He, R, Howell, M.D, Freyschmidt, E, Oettgen, H.C, Leung, D.Y.M, Geha, R.S

“…Eczema Vaccinatum (EV) is a complication of smallpox vaccination that affects patients with atopic dermatitis (AD)…”
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629 Performance monitoring of a streamlined and scalable non-invasive gene expression assay for pigmented lesions by Kaur, K., Allen, T., Hill, K., Howell, M.D., Jansen, B., Rock, J., Clarke, L., Ibarra, C.

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