Search Results - "Howell, Alexandra"

PlmCas12e (CasX2) cleavage of CCR5: impact of guide RNA spacer length and PAM sequence on cleavage activity by Armstrong, David A., Hudson, Taylor R., Hodge, Christine A., Hampton, Thomas H., Howell, Alexandra L., Hayden, Matthew S.

“…Gene editing using CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR-associated) is under development as a therapeutic tool for the…”
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An Investigation of Oxygen Availability in Spreading Fires by Howell, Alexandra N., Belmont, Erica L., McAllister, Sara S., Finney, Mark A.

“…Wildfire spread models that couple physical transport and chemical kinetics sometimes simplify or neglect gas-phase pyrolysis product oxidation chemistry…”
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Toll-like receptor agonists are potent inhibitors of human immunodeficiency virus-type 1 replication in peripheral blood mononuclear cells by Buitendijk, Maarten, Eszterhas, Susan K, Howell, Alexandra L

“…Innate immune responses to microbial pathogens are initiated following the binding of ligand to specific pattern recognition receptors. Each pattern…”
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Analysis of CRISPR/Cas9 Guide RNA Efficiency and Specificity Against Genetically Diverse HIV-1 Isolates by Sessions, Katherine J, Chen, Yun Yue, Hodge, Christine A, Hudson, Taylor R, Eszterhas, Susan K, Hayden, Matthew S, Howell, Alexandra L

“…Gene editing approaches using CRISPR/Cas9 are being developed as a means for targeting the integrated HIV-1 provirus. Enthusiasm for the use of gene editing as…”
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Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells by Buitendijk, Maarten, Eszterhas, Susan K, Howell, Alexandra L

“…Immune response modifiers are being studied as therapeutic agents for viral infections and cancer. These molecules include agonists for the Toll-like receptors…”
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A mathematical model of HIV dynamics treated with a population of gene-edited haematopoietic progenitor cells exhibiting threshold phenomenon by Ratti, Vardayani, Nanda, Seema, Eszterhas, Susan K, Howell, Alexandra L, Wallace, Dorothy I

“…The use of gene-editing technology has the potential to excise the CCR5 gene from haematopoietic progenitor cells, rendering their differentiated CD4-positive…”
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Health-related quality of life and social determinants of health following COVID-19 infection in a predominantly Latino population by Case, Kathleen R., Wang, Chen-Pin, Hosek, Meredith G., Lill, Sarah F., Howell, Alexandra B., Taylor, Barbara S., Bridges, James, MacCarthy, Daniel J., Winkler, Paula, Tsevat, Joel

“…Background As the COVID-19 pandemic evolves, more information is needed on its long-term impacts on health-related quality of life (HRQoL) and social…”
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HIV Type 1 Infection in Women: Increased Transcription of HIV Type 1 in Ectocervical Tissue Explants by Asin, Susana N., Eszterhas, Susan K., Rollenhagen, Christiane, Heimberg, Alysha M., Howell, Alexandra L.

“…BackgroundMucosal surfaces of the female reproductive tract are the main routes of heterosexual transmission of human immunodeficiency virus type 1 (HIV-1),…”
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Human Uterine Natural Killer Cells but Not Blood Natural Killer Cells Inhibit Human Immunodeficiency Virus Type 1 Infection by Secretion of CXCL12 by MSELLE, Teddy F, HOWELL, Alexandra L, GHOSH, Mimi, WIRA, Charles R, SENTMAN, Charles L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Breast Milk from Tanzanian Women Has Divergent Effects on Cell-Free and Cell-Associated HIV-1 Infection In Vitro by Lyimo, Magdalena A, Mosi, Matilda Ngarina, Housman, Molly L, Zain-Ul-Abideen, Muhammad, Lee, Frederick V, Howell, Alexandra L, Connor, Ruth I

“…Transmission of HIV-1 during breastfeeding is a significant source of new pediatric infections in sub-Saharan Africa. Breast milk from HIV-positive mothers…”
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Unifying yet dividing: voices of pussyhat maker–wearers who participated in the 2017 Women’s Marches by Malcom, Nancy L., Martindale, Addie K., Paulins, V. Ann, Hillery, Julie L., Howell, Alexandra

“…On January 21, 2017, several million protesters took part in the “Women’s March on Washington” and its more than 400 sister Marches held in cities throughout…”
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Innate Factors in Human Breast Milk Inhibit Cell-Free HIV-1 but Not Cell-Associated HIV-1 Infection of CD4+ Cells by Lyimo, Magdalena A, Howell, Alexandra L, Balandya, Emmanuel, Eszterhas, Susan K, Connor, Ruth I

“…BACKGROUND:Transmission of HIV from mother to child through breast-feeding remains a global health challenge, particularly in developing countries. Breast milk…”
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Estradiol and progesterone regulate HIV type 1 replication in peripheral blood cells by Asin, Susana N, Heimberg, Alysha M, Eszterhas, Susan K, Rollenhagen, Christiane, Howell, Alexandra L

“…Endogenous levels of estradiol and progesterone fluctuate in the peripheral blood of premenopausal women during the reproductive cycle. We studied the effects…”
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Diffuse erythema and edema of the oral mucosa by Glass, Sarah, Howell, Alexandra

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Toward a VA Women's Health Research Agenda: Setting Evidence‐based Priorities to Improve the Health and Health Care of Women Veterans by Yano, Elizabeth M., Bastian, Lori A., Frayne, Susan M., Howell, Alexandra L., Lipson, Linda R., McGlynn, Geraldine, Schnurr, Paula P., Seaver, Margaret R., Spungen, Ann M., Fihn, Stephan D.

“…The expansion of women in the military is reshaping the veteran population, with women now constituting the fastest growing segment of eligible VA health care…”
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Transmission of HIV-1 by Primary Human Uterine Epithelial Cells and Stromal Fibroblasts by Asin, Susana N., Fanger, Michael W., Wildt-Perinic, Dunja, Ware, Patricia L., Wira, Charles R., Howell, Alexander L.

“…Women can become infected with human immunodeficiency virus type 1 (HIV-1) after the heterosexual transmission of virus from an infected male partner. To…”
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Chemokine receptor expression in the human ectocervix: implications for infection by the human immunodeficiency virus‐type I by Yeaman, Grant R., Asin, Susana, Weldon, Sally, Demian, Douglas J., Collins, Jane E., Gonzalez, Jorge L., Wira, Charles R., Fanger, Michael W., Howell, Alexandra L.

“…Summary Human immunodeficiency virus‐type 1 (HIV‐1) is a sexually transmitted pathogen that can infect cells in the female reproductive tract (FRT). The…”
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Intravenous fentanyl increases natural killer cell cytotoxicity and circulating CD16+ lymphocytes in humans by YEAGER, Mark P, PROCOPIO, Marcia A, DELEO, Joyce A, ARRUDA, Janice L, HILDEBRANDT, Laurie, HOWELL, Alexandra L

“…Opioids, including fentanyl, are often administered to patients who may be at risk for the consequences of impaired immune function. We performed a clinical…”
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Nanoparticles containing siRNA to silence CD4 and CCR5 reduce expression of these receptors and inhibit HIV-1 infection in human female reproductive tract tissue explants by Eszterhas, Susan K., Ilonzo, Nicole O., Crozier, Jennifer E., Celaj, Stela, Howell, Alexandra L.

“…Human Immunodeficiency Virus-type 1 (HIV-1) binds to CD4 and CCR5 receptors on target cells in the human female reproductive tract. We sought to determine…”
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Stable polycyclic aromatic carbon (SPAC) formation in wildfire chars and engineered biochars by Howell, Alexandra, Helmkamp, Sophia, Belmont, Erica

“…Pyrogenic carbon (PyC) is an important component of wildfire chars and engineered biochars due to its potential environmental longevity, the most…”
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