Search Results - "Howe, W. Jeffrey"

Epilogue to the Gerald Maggiora Festschrift: a tribute to an exemplary mentor, colleague, collaborator, and innovator by Shanmugasundaram, Veerabahu, Bajorath, Jürgen, Christoffersen, Ralph E., Petke, James D., Howe, W. Jeffrey, Johnson, Mark A., Agrafiotis, Dimitris K., Lee, Pil, Kuhn, Leslie A., Goodwin, Jay T., Holloway, M. Katharine, Doman, Thompson N., Walters, W. Patrick, Schreyer, Suzanne, Medina-Franco, José L., Martinez-Mayorga, Karina, Restifo, Linda L.

“…In May 2022, JCAMD published a Special Issue in honor of Gerald (Gerry) Maggiora, whose scientific leadership over many decades advanced the fields of…”
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Prediction of the Tertiary Structure of the β-Secretase Zymogen by Chou, Kuo-Chen, Howe, W.Jeffrey

“…β-Secretase, also known as BACE, is a transmembrane aspartyl protease, which generates the N terminus of Alzheimer's disease amyloid β-peptide. The activity of…”
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Protein Binding Chiral Discrimination of HPLC Stationary Phases Made with Whole, Fragmented, and Third Domain Turkey Ovomucoid by Pinkerton, Thomas C, Howe, W. Jeffrey, Ulrich, Eldon L, Comiskey, Joseph P, Haginaka, Jun, Murashima, Tokiko, Walkenhorst, William F, Westler, William M, Markley, John L

“…Individual protein domains and two domains in combination were prepared by enzymatic and chemical cleavage of turkey ovomucoid followed by isolation and…”
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Computer design of bioactive molecules: a method for receptor-based de novo ligand design by Moon, J B, Howe, W J

“…The design of molecules to bind specifically to protein receptors has long been a goal of computer-assisted molecular design. Given detailed structural…”
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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors by Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P

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CXC Chemokines Connective Tissue Activating Peptide-III and Neutrophil Activating Peptide-2 are Heparin/Heparan Sulfate-degrading Enzymes (∗) by Hoogewerf, Arlene J., Leone, Joseph W., Reardon, Ilene M., Howe, W.Jeffrey, Asa, Darwin, Heinrikson, Robert L., Ledbetter, Steven R.

“…Heparan sulfate proteoglycans at cell surfaces or in extracellular matrices bind diverse molecules, including growth factors and cytokines, and it is believed…”
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Cycloalkylpyranones and Cycloalkyldihydropyrones as HIV Protease Inhibitors:  Exploring the Impact of Ring Size on Structure−Activity Relationships by Romines, Karen R, Morris, Jeanette K, Howe, W. Jeffrey, Tomich, Paul K, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Anderson, David J, Strohbach, Joseph W, Turner, Steve R, Mizsak, Steve A

“…Previously, 3-substituted cycloalkylpyranones, such as 2d, have proven to be effective inhibitors of HIV protease. In an initial series of 3-(1-phenylpropyl)…”
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General methods of synthetic analysis. Strategic bond disconnections for bridged polycyclic structures by Corey, E. J, Howe, W. Jeffrey, Orf, H. W, Pensak, David A, Petersson, George

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Computer-assisted synthetic analysis. Methods for machine generation of synthetic intermediates involving multistep look-ahead by Corey, E. J, Howe, W. Jeffrey, Pensak, David A

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Computer-assisted synthetic analysis for complex molecules. Methods and procedures for machine generation of synthetic intermediates by Corey, E. J, Cramer, Richard D, Howe, W. Jeffrey

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Computer-assisted synthetic analysis. Facile man-machine communication of chemical structure by interactive computer graphics by Corey, E. J, Wipke, W. Todd, Cramer, Richard D, Howe, W. Jeffrey

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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors:  The Sulfonamide-Substituted Cyclooctylpyranones by Skulnick, Harvey I, Johnson, Paul D, Aristoff, Paul A, Morris, Jeanette K, Lovasz, Kristine D, Howe, W. Jeffrey, Watenpaugh, Keith D, Janakiraman, Musiri N, Anderson, David J, Reischer, Robert J, Schwartz, Theresa M, Banitt, Lee S, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Dolak, Lester A, Seest, Eric P, Schwende, Francis J, Rush, Bob D, Howard, Gina M, Toth, Lisa N, Wilkinson, Karen R, Kakuk, Thomas J, Johnson, Carol W, Cole, Serena L, Zaya, Renee M, Zipp, Gail L, Possert, Peggy L, Dalga, Robert J, Zhong, Wei-Zhu, Williams, Marta G, Romines, Karen R

“…Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors, but these…”
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The HIV-1 Protease as Enzyme and Substrate: Mutagenesis of Autolysis Sites and Generation of a Stable Mutant with Retained Kinetic Properties by Mildner, Ana M, Rothrock, Donna J, Leone, Joseph W, Bannow, Carol A, Lull, June M, Reardon, Ilene M, Sarcich, Jean L, Howe, W. Jeffrey, Tomich, Che-Shen C

“…Site-directed mutagenesis of autolysis sites in the human immunodeficiency virus type 1 (HIV-1) protease was applied in an analysis of enzyme specificity; the…”
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Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors by Thaisrivongs, Suvit, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Dolak, Lester A, Chong, Kong-Teck, Tomich, Che-Shen C, Tomasselli, Alfredo G, Turner, Steve R

“…The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents…”
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Structure-Based Design of HIV Protease Inhibitors:  5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors by Thaisrivongs, Suvit, Romero, Donna L, Tommasi, Ruben A, Janakiraman, Musiri N, Strohbach, Joseph W, Turner, Steve R, Biles, Carolyn, Morge, Raymond R, Johnson, Paul D, Aristoff, Paul A, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Howe, W. Jeffrey, Finzel, Barry C, Watenpaugh, Keith D

“…From a broad screening program, the 4-hydroxycoumarin phenprocoumon (I) was previously identified as a lead template with HIV protease inhibitory activity. The…”
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Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors by Romines, Karen R, Watenpaugh, Keith D, Tomich, Paul K, Howe, W. Jeffrey, Morris, Jeanette K, Lovasz, Kristine D, Mulichak, Anne M, Finzel, Barry C, Lynn, Janet C

“…A unique strategy for the enhancement of secondary binding of an inhibitor to an enzyme has been demonstrated in the design of new human immunodeficiency virus…”
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Crystal structure of a complex of HIV‐1 protease with a dihydroxyethylene‐containing inhibitor: Comparisons with molecular modeling by Thanki, Narmada, Rao, J.K. Mohana, Foundling, Stephen I., Wlodawer, Alexander, Howe, W. Jeffrey, Moon, Joseph B., Hui, John O., Tomasselli, Alfredo G., Heinrikson, Robert L., Thaisrivongs, Suvit

“…The structure of a crystal complex of recombinant human immunodeficiency virus type 1 (HIV‐1) protease with a peptide‐mimetic inhibitor containing a…”
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Specificity and inhibition of proteases from human immunodeficiency viruses 1 and 2 by Tomasselli, A G, Hui, J O, Sawyer, T K, Staples, D J, Bannow, C, Reardon, I M, Howe, W J, DeCamp, D L, Craik, C S, Heinrikson, R L

“…Highly purified, recombinant preparations of the virally encoded proteases from human immunodeficiency viruses (HIV) 1 and 2 have been compared relative to 1)…”
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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure by Romines, Karen R, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Lovasz, Kristine D, Morris, Jeanette K, Janakiraman, Musiri N, Lynn, Janet C, Horng, Miao-Miao

“…Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2…”
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Human immunodeficiency virus type‐1 reverse transcriptase and ribonuclease h as substrates of the viral protease by Tomasselli, Alfredo G., Sarcich, Jean L., Barrett, Linda J., Reardon, Ilene M., Howe, W. Jeffrey, Evans, David B., Sharma, Satish K., Heinrikson, Robert L.

“…A study has been made of the susceptibility of recombinant constructs of reverse transcriptase (RT) and ribonuclease H (RNase H) from human immunodeficiency…”
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