Search Results - "Howe, W J"

Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors by Thaisrivongs, Suvit, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Dolak, Lester A, Chong, Kong-Teck, Tomich, Che-Shen C, Tomasselli, Alfredo G, Turner, Steve R

“…The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents…”
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Structure-Based Design of HIV Protease Inhibitors:  5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors by Thaisrivongs, Suvit, Romero, Donna L, Tommasi, Ruben A, Janakiraman, Musiri N, Strohbach, Joseph W, Turner, Steve R, Biles, Carolyn, Morge, Raymond R, Johnson, Paul D, Aristoff, Paul A, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Howe, W. Jeffrey, Finzel, Barry C, Watenpaugh, Keith D

“…From a broad screening program, the 4-hydroxycoumarin phenprocoumon (I) was previously identified as a lead template with HIV protease inhibitory activity. The…”
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Visual evoked cortical potentials and pattern electroretinograms in Parkinson's disease and control subjects by Nightingale, S, Mitchell, K W, Howe, J W

“…Parkinson's disease patients have been shown to have abnormal visually evoked cortical potentials (VEPs) to pattern stimulation. Whereas dopamine is not an…”
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Prediction of the Tertiary Structure of the β-Secretase Zymogen by Chou, Kuo-Chen, Howe, W.Jeffrey

“…β-Secretase, also known as BACE, is a transmembrane aspartyl protease, which generates the N terminus of Alzheimer's disease amyloid β-peptide. The activity of…”
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Crystal structure of a complex of HIV‐1 protease with a dihydroxyethylene‐containing inhibitor: Comparisons with molecular modeling by Thanki, Narmada, Rao, J.K. Mohana, Foundling, Stephen I., Wlodawer, Alexander, Howe, W. Jeffrey, Moon, Joseph B., Hui, John O., Tomasselli, Alfredo G., Heinrikson, Robert L., Thaisrivongs, Suvit

“…The structure of a crystal complex of recombinant human immunodeficiency virus type 1 (HIV‐1) protease with a peptide‐mimetic inhibitor containing a…”
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Computer design of bioactive molecules: a method for receptor-based de novo ligand design by Moon, J B, Howe, W J

“…The design of molecules to bind specifically to protein receptors has long been a goal of computer-assisted molecular design. Given detailed structural…”
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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure by Romines, Karen R, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Lovasz, Kristine D, Morris, Jeanette K, Janakiraman, Musiri N, Lynn, Janet C, Horng, Miao-Miao

“…Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2…”
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Human immunodeficiency virus type‐1 reverse transcriptase and ribonuclease h as substrates of the viral protease by Tomasselli, Alfredo G., Sarcich, Jean L., Barrett, Linda J., Reardon, Ilene M., Howe, W. Jeffrey, Evans, David B., Sharma, Satish K., Heinrikson, Robert L.

“…A study has been made of the susceptibility of recombinant constructs of reverse transcriptase (RT) and ribonuclease H (RNase H) from human immunodeficiency…”
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Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity by Thaisrivongs, Suvit, Tomasselli, Alfredo G, Moon, Joseph B, Hui, John, McQuade, Thomas J, Turner, Steve R, Strohbach, Joseph W, Howe, W. Jeffrey, Tarpley, W. Gary, Heinrikson, Robert L

“…The peptidomimetic template and the dihydroxyethylene isostere insert that were applied successfully to the design of renin inhibitors have been extended to…”
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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors by Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P

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Globe luxation in histiocytosis X by Wood, C M, Pearson, A D, Craft, A W, Howe, J W

“…A boy with histiocytosis X, first diagnosed at the age of 9 months, presented at the age of 5 years with left globe luxation. Under general anaesthesia the…”
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Complicated migraine resulting in blindness due to bilateral retinal infarction by Glenn, A M, Shaw, P J, Howe, J W, Bates, D

“…Retinal migraine is not uncommon, but permanent sequelae in the anterior visual pathway are rare. We describe the case of a young woman in whom blindness…”
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The objective assessment of contrast sensitivity function by electrophysiological means by Howe, J W, Mitchell, K W

“…In recent years it has been shown that it is of considerable clinical value to determine the visual contrast sensitivity function of the patient. This can…”
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Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere by Thaisrivongs, Suvit, Turner, Steve R, Strohbach, Joseph W, TenBrink, Ruth E, Tarpley, W. Gary, McQuade, Thomas J, Heinrikson, Robert L, Tomasselli, Alfredo G, Hui, John O, Howe, W. Jeffrey

“…A number of potential HIV protease inhibitory peptides that contain the dihydroxyethylene isostere were prepared and evaluated for their enzyme binding…”
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Prognostic significance of the pattern visual evoked potential in ocular hypertension by Bray, L C, Mitchell, K W, Howe, J W

“…This paper reports a prospective study on 49 ocular hypertensive patients to evaluate the prognostic significance of transient abnormalities in the pattern…”
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Pattern visual evoked potentials in hyperthyroidism by Mitchell, K W, Wood, C M, Howe, J W

“…Pattern reversal visual evoked potentials (VEPs) have been elicited in 16 female hyperthyroid patients before and after treatment and compared with those from…”
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Visual evoked potential latency and contrast sensitivity in patients with posterior chamber intraocular lens implants by Howe, J. W., Mitchell, K. W., Mahabaleswara, M., Abdel-Khalek, M. N.

“…An electrophysiological investigation of visual evoked potential (VEP) latency and contrast sensitivity was performed in a group of 13 patients who had…”
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Visual evoked cortical potential to paracentral retinal stimulation in chronic glaucoma, ocular hypertension, and an age-matched group of normals by HOWE, J. W, MITCHELL, K. W

“…Visual evoked cortical potentials (VECPs) to midperipheral stimulation of the visual field were elicited in age-matched groups of patients with unilateral…”
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Electrophysiologically determined contrast sensitivity in patients with ocular hypertension and chronic glaucoma by HOWE, J. W, MITCHELL, K. W

“…Subjectively assessed contrast sensitivity has been found to be abnormal in many patients with glaucoma. We previously reported the use of onset-offset visual…”
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The visual evoked potential in acute primary angle closure glaucoma by Mitchell, K. W., Wood, C. M., Howe, J. W., Church, W. H., Smith, G. T., Spencer, S. R.

“…Visual evoked potentials (VEPs) were elicited from 29 patients who had experienced a previous attack of acute primary angle closure glaucoma. The VEPs were…”
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