Search Results - "Howe, Louise"

Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer by Howe, Louise R

“…Many human cancers exhibit elevated prostaglandin (PG) levels due to upregulation of cyclooxygenase-2 (COX-2), a key enzyme in eicosanoid biosynthesis. COX-2…”
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Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer by HOWE, Louise R, SUBBARAMAIAH, Kotha, HUDIS, Clifford A, DANNENBERG, Andrew J

“…The increasing rate of obesity worldwide is predicted to be associated with a surge in diseases. Notably, obesity has been linked to approximately 20% of…”
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Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer by Iyengar, Neil M, Zhou, Xi Kathy, Gucalp, Ayca, Morris, Patrick G, Howe, Louise R, Giri, Dilip D, Morrow, Monica, Wang, Hanhan, Pollak, Michael, Jones, Lee W, Hudis, Clifford A, Dannenberg, Andrew J

“…Obesity, insulin resistance, and elevated levels of circulating proinflammatory mediators are associated with poorer prognosis in early-stage breast cancer. To…”
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Identification of PADI2 as a potential breast cancer biomarker and therapeutic target by McElwee, John L, Mohanan, Sunish, Griffith, Obi L, Breuer, Heike C, Anguish, Lynne J, Cherrington, Brian D, Palmer, Ashley M, Howe, Louise R, Subramanian, Venkataraman, Causey, Corey P, Thompson, Paul R, Gray, Joe W, Coonrod, Scott A

“…We have recently reported that the expression of peptidylarginine deiminase 2 (PADI2) is regulated by EGF in mammary cancer cells and appears to play a role in…”
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Activation status of Wnt/ß-catenin signaling in normal and neoplastic breast tissues: relationship to HER2/neu expression in human and mouse by Khalil, Sara, Tan, Grace A, Giri, Dilip D, Zhou, Xi Kathy, Howe, Louise R

“…Wnt/ß-catenin signaling is strongly implicated in neoplasia, but the role of this pathway in human breast cancer has been controversial. Here, we examined…”
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Targeting the HER/EGFR/ErbB family to prevent breast cancer by Howe, Louise R, Brown, Powel H

“…Preventing breast cancer is possible with selective estrogen receptor (ER) modulators and aromatase inhibitors, which reduce the risk of invasive disease by up…”
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Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland by Subbaramaiah, Kotha, Howe, Louise R, Bhardwaj, Priya, Du, Baoheng, Gravaghi, Claudia, Yantiss, Rhonda K, Zhou, Xi Kathy, Blaho, Victoria A, Hla, Timothy, Yang, Peiying, Kopelovich, Levy, Hudis, Clifford A, Dannenberg, Andrew J

“…Elevated circulating estrogen levels are associated with increased risk of breast cancer in obese postmenopausal women. Following menopause, the biosynthesis…”
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Retraction: Pioglitazone, a PPARγ Agonist, Suppresses CYP19 Transcription: Evidence for Involvement of 15-Hydroxyprostaglandin Dehydrogenase and BRCA1 by Subbaramaiah, Kotha, Howe, Louise R, Zhou, Xi Kathy, Yang, Peiying, Hudis, Clifford A, Kopelovich, Levy, Dannenberg, Andrew J

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Establishing estrogen-responsive mouse mammary organoids from single Lgr5 + cells by Zhang, Lixing, Adileh, Mohammad, Martin, Maria Laura, Klingler, Stefan, White, Julie, Ma, Xiaojing, Howe, Louise R, Brown, Anthony M C, Kolesnick, Richard

“…Recent evidence suggests that mammary cells expressing R-spondin receptor and Wnt pathway regulator Lgr5, regarded as a stem cell marker in multiple tissues,…”
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Wnt Signaling and Breast Cancer by Howe, Louise R., Brown, Anthony M.C.

“…Secreted signaling factors of the Wnt protein family regulate many cellular processes, including cell fate decisions and cell proliferation, and aberrant Wnt…”
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Social participation in the promoting activity, independence and stability in early dementia (PrAISED), a home-based therapy intervention for people living with dementia: a realist evaluation by Lorito, Claudio Di, Pollock, Kristian, Booth, Vicky, Howe, Louise, Goldberg, Sarah, Godfrey, Maureen, Dunlop, Marianne, Harwood, Rowan H, Wardt, Veronika van der

“…Interventions promoting social activity may reduce behavioural psychological symptoms and improve quality of life in people living with dementia. This study…”
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Cyclooxygenase-2-Derived Prostacyclin Regulates Arterial Thrombus Formation by Suppressing Tissue Factor in a Sirtuin-1―Dependent-Manner by BARBIERI, Silvia S, AMADIO, Patrizia, GIANELLINI, Sara, TARANTINO, Eva, ZACCHI, Elena, VEGLIA, Fabrizio, HOWE, Louise R, WEKSLER, Babette B, MUSSONI, Luciana, TREMOLI, Elena

“…Selective inhibitors of cyclooxygenase (COX)-2 increase the risk of myocardial infarction and thrombotic events, but the responsible mechanisms are not fully…”
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Retraction: Obesity Is Associated With Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland by Subbaramaiah, Kotha, Howe, Louise R, Bhardwaj, Priya, Du, Baoheng, Gravaghi, Claudia, Yantiss, Rhonda K, Zhou, Xi Kathy, Blaho, Victoria A, Hla, Timothy, Yang, Peiying, Kopelovich, Levy, Hudis, Clifford A, Dannenberg, Andrew J

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Rexinoids and breast cancer prevention by Howe, Louise R

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Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation by HOWE, Louise R, WATANABE, Osamu, LEONARD, James, BROWN, Anthony M. C

“…Wnt1, initially identified as a mammary oncogene, can activate transcription via beta-catenin/TCF complexes. Twist, a transcription factor of the basic…”
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Protocol for the process evaluation of the Promoting Activity, Independence and Stability in Early Dementia (PrAISED), following changes required by the COVID-19 pandemic by Di Lorito, Claudio, Bosco, Alessandro, Goldberg, Sarah E, Nair, Roshan, O'Brien, Rebecca, Howe, Louise, van der Wardt, Veronika, Pollock, Kristian, Booth, Vicky, Logan, Pip, Godfrey, Maureen, Dunlop, Marianne, Horne, Jane, Harwood, Rowan H

“…The Promoting Activity, Independence and Stability in Early Dementia (PrAISED) randomised controlled trial (RCT) is evaluating a home-based, face-to-face,…”
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Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer by Dannenberg, A J, Altorki, N K, Boyle, J O, Dang, C, Howe, L R, Weksler, B B, Subbaramaiah, K

“…Understanding the mechanisms underlying carcinogenesis provides insights that are necessary for the development of therapeutic strategies to prevent cancer…”
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HER-2/neu status is a determinant of mammary aromatase activity in vivo : Evidence for a cyclooxygenase-2-dependent mechanism by SUBBARAMAIAH, Kotha, HOWE, Louise R, PORT, Elisa R, BROGI, Edi, FISHMAN, Jack, LIU, Catherine H, HLA, Timothy, HUDIS, Clifford, DANNENBERG, Andrew J

“…Cytochrome P450 aromatase (aromatase), a product of the CYP19 gene, catalyzes the synthesis of estrogens from androgens. Given the significance of estrogen…”
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Pea3 transcription factors and wnt1-induced mouse mammary neoplasia by Baker, Rebecca, Kent, Claire V, Silbermann, Rachel A, Hassell, John A, Young, Lawrence J T, Howe, Louise R

“…The role of the PEA3 subfamily of Ets transcription factors in breast neoplasia is controversial. Although overexpression of PEA3 (E1AF/ETV4), and of the…”
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Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1 by Subbaramaiah, Kotha, Howe, Louise R, Zhou, Xi Kathy, Yang, Peiying, Hudis, Clifford A, Kopelovich, Levy, Dannenberg, Andrew J

“…Estrogen synthesis is catalyzed by cytochrome P450 aromatase, which is encoded by the CYP19 gene. In obese postmenopausal women, increased aromatase activity…”
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